A5100649204- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Antibiotics Pharmacokinetics and Efficacy
- Proteoglycans and glycosaminoglycans research
- Ferroptosis and cancer prognosis
- Antibiotic Resistance in Bacteria
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Fibroblast Growth Factor Research
- Biotin and Related Studies
- Thyroid Cancer Diagnosis and Treatment
- Hepatitis C virus research
- Myasthenia Gravis and Thymoma
- Hepatocellular Carcinoma Treatment and Prognosis
- Antifungal resistance and susceptibility
- S100 Proteins and Annexins
- Biopolymer Synthesis and Applications
- Retinoids in leukemia and cellular processes
- Bacterial biofilms and quorum sensing
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Chronic Myeloid Leukemia Treatments
Tsinghua–Berkeley Shenzhen Institute
2024
Qilu Hospital of Shandong University
2011-2024
Soochow University
2023
Hubei Cancer Hospital
2020
Second Affiliated Hospital of Xi'an Jiaotong University
2017
Boston Biomedical (United States)
2017
Xiangya Hospital Central South University
2017
Central South University
2017
Army Medical University
2016
Cancer Genetics (United States)
2015
Importance Myasthenia gravis (MG) is caused by autoantibodies that disrupt the neuromuscular junction. The neonatal fragment crystallizable receptor (FcRn) antagonists, efgartigimod and rozanolixizumab, reduce immunoglobulin G (IgG) level in circulation alleviate symptoms patients with generalized MG. Objective To examine efficacy safety profile of batoclimab, a monoclonal IgG1 antibody, Design, Setting, Participants This was multicenter randomized clinical trial conducted from September 15,...
We previously showed that a long noncoding RNA gene, PTCSC3, located close to the variant rs944289 predisposes papillary thyroid carcinoma (PTC) might target S100A4 gene. The aim was investigate impact of PTCSC3 on expression and its role in cancer development. abundance analyzed by quantitative PCR (qPCR) unaffected tumor tissue from n = 73 PTC patients. studied BCPAP TPC-1 cell lines with forced qPCR. Expression genes (VEGF MMP-9) line qPCR, reverse transcriptase PCR, Western blot....
Abstract Osteoarthritis (OA) in the temporomandibular joint (TMJ) is a common degenerative disease adult, which characterized by progressive destruction of articular cartilage. To investigate role FGFR3 homeostasis TMJ cartilage during adult stage, we generated Fgfr3 f/f ; Col2a1-CreER T2 ( cKO) mice, was deleted chondrocytes at 2 months age. OA-like defects were observed cKO Immunohistochemical staining and quantitative real-time PCR analyses revealed significant increase expressions COL10,...
Purpose: Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute progression. In our study, we aimed investigate the expression clinical pertinence serine peptidase inhibitor, Kunitz type 1 RNA1 ( SPINT1-AS1 ) CRC. Materials methods: The levels corresponding sense transcript SPINT1 mRNA were analyzed 150 pairs CRC tissues adjacent normal (AN)...
Abstract Several prognostic indicators have shown inconsistencies in patients of different genders with lung adenocarcinoma, indicating that these variations may be due to the genetic background males and females adenocarcinoma. In this study, we first used Gene-Cloud Biotechnology Information (GCBI) bioinformatics platform identify differentially expressed genes (DEGs) eliminated gender differences between adenocarcinoma normal tissues. Then, screened out transcription factor 21 (TCF21) is...
3529 Background: Cancer stem cells are considered to be fundamentally important for resistance, recurrence and metastasis. Napabucasin is a first-in-class cancer stemness inhibitor in development identified by its ability inhibit STAT3-driven gene transcription spherogenesis of (Li et al, PNAS 112(6):1839, 2015). Preclinically, napabucasin sensitizes chemotherapy targeted agents. Methods: A phase Ib/II multi-center study mCRC pts was done confirm the RP2D signs anti-cancer activity...
Extensively drug-resistant Acinetobacter baumannii (XDR-AB) infections have become difficult to treat and are associated with a high mortality rate. Tigecycline is one of the most effective agents used XDR-AB infections, but data from treating bloodstream infection (BSI) in standard dose do not look promising, because its low plasma concentration. Secondary BSI primary source may indicate tigecycline treatment higher dose. Currently, little known about application high-dose among patients...
Introduction Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a growing threat. It urgent to investigate the multidrug resistance and high virulence of CRPA provide basis for infection control rational use antibiotics. Methods A retrospective study 56 nonduplicated isolates was conducted. Results mainly came from intensive care unit (ICU) mostly isolated sputum samples. The carbapenem rates P. were 21.37% (2016), 10.62, 5.88, 10 13.87% 2016 2020, respectively. enzymes...
Abstract Background High-dose cytarabine (HDAC) is commonly used for consolidation therapy in young acute myeloid leukemia (AML) patients, but the dosage of still controversial clinic due to its obvious post-chemotherapy adverse effects. The aim this study was contrast efficacy different dose groups after Chinese AML patients. Methods patients treated with at Qilu Hospital, Shandong University from January 2010 September 2022 were retrospectively analyzed, which 346 relatively complete...
Type 2 diabetes (T2D) presents a significant health challenge, underscoring the need for functional foods and nutraceutical hypoglycemic bioactive peptides its prevention. This study investigates potential of proteolytic hydrolysate from artificially cultivated Chinese giant salamander (CGS) meat, rich protein source, as preventive strategy T2D. We produced CGS meat (CGSh) demonstrated ability to inhibit T2D drug target DPP-IV through <em>in vitro</em> assays. identified five (WRPPDH,...
Background: Laryngeal squamous cell carcinoma (LSCC) ranks second in the mortality rate respiratory malignant tumors and has potential similarity genomic alterations with esophageal (ESCC).The PLCE1 rs2274223 variant is most significant susceptibility loci identified ESCC.Whether it also associated LSCC still unclear.Materials Methods: A total of 331 patients 349 healthy controls were recruited this study.The was genotyped by using Taqman SNP Genotyping Assay.Association between risk...
This study was to investigate the differential mitochondrial protein expressions in human lung adenocarcinoma and provide preliminary data for further exploration of carcinogenic mechanism.Total proteins A549 16HBE mitochondria were extracted through 2D polyacrylamide gel electrophoresis (2-DE). The identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) confirmed Western blot, immunoelectron microscopy immunohistochemistry (IHC) cells as well tissues.A total 41...
Objective To investigate the changes of miR-301a and its host gene expression SKA2 in LNCaP prostate cancer xenografts castrated nude mice.Methods cells were inoculated subcutaneously mice to establish xenograft models human cancer.When tumor volume grew 200 mm3,the randomly divided into following 4 groups(n =6): 2 groups surgical castration,the other as control groups.The growth those xnografts was observed weekly a curve drawn.A point time during process tumor-regressing selected when...
Although gene therapy has been considered one of the most promising therapeutic approaches for both genetic disorders and acquired diseases, such as cancers infectious in only a few circumstances success documented (Gene Therapy 1996;7:1781-80 ). Current challenges to include lack efficient delivery systems, absence sustained expression, and, some agents, vigor host immune reactions (Nature 1997;389:239-42 Retroviral vectors have be among logical achieve long-term expression by incorporating...