A5100444084- Advanced Operator Algebra Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Advanced Topics in Algebra
- MicroRNA in disease regulation
- Homotopy and Cohomology in Algebraic Topology
- Algebraic structures and combinatorial models
- Lipid metabolism and disorders
- Holomorphic and Operator Theory
- Embedded Systems and FPGA Design
- Evaluation Methods in Various Fields
- Advanced Software Engineering Methodologies
- Caching and Content Delivery
- Media, Communication, and Education
- Advanced Text Analysis Techniques
- Network Packet Processing and Optimization
- Diamond and Carbon-based Materials Research
- Financial Risk and Volatility Modeling
- NF-κB Signaling Pathways
- Synthesis and biological activity
- Cytokine Signaling Pathways and Interactions
- Power Systems and Renewable Energy
- Carcinogens and Genotoxicity Assessment
- Global Energy Security and Policy
- Educational Technology and Pedagogy
Wuxi People's Hospital
2023
Nanjing Medical University
2023
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2022
Jiangsu Provincial Academy of Traditional Chinese Medicine
2021
Hebei Medical University
2013-2020
Qingdao University
2019
Evotec (Germany)
2016
Institute of Zoology
2015
Second Hospital of Hebei Medical University
2013-2015
University of Chinese Academy of Sciences
2015
Air pollution has been classified as Group 1 carcinogenic to humans, but the underlying tumorigenesis remains unclear. In Xuanwei City of Yunnan Province, lung cancer incidence is among highest in China attributed severe air generated by combustion smoky coal, providing a unique opportunity dissect carcinogenesis pollution. Here we analyzed somatic mutations 164 non-small cell cancers (NSCLCs) from and control regions (CR) where coal was not used. Whole genome sequencing revealed mean 289...
We report here structure-guided optimization of a novel series NF-κB inducing kinase (NIK) inhibitors. Starting from modestly potent, low molecular weight lead, activity was improved by designing type 11/2 binding mode that accessed back pocket past the methionine-471 gatekeeper. Divergent modes in NIK and PI3K were exploited to dampen inhibition while maintaining within these series. Potent compounds discovered selectively inhibit nuclear translocation NF-κB2 (p52/REL-B) but not canonical...
Federated Learning (FL) enables clients to collaboratively train machine learning models without sharing local data, preserving privacy in diverse environments. While traditional FL approaches preserve privacy, they often struggle with high computational and communication overhead. To address these issues, model pruning is introduced as a strategy streamline computations. However, existing methods, when applied solely based on produce sub-models that inadequately reflect clients' specific...
MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs that regulate gene expression by post-transcriptional repression mRNAs. Recently, several miRNAs have been confirmed to execute directly or indirectly osmoregulatory functions in fish via translational control. In order clarify whether play relevant roles the osmoregulation Anguilla marmorata, three sRNA libraries A. marmorata during adjusting various salinities were sequenced Illumina deep sequencing methods. Totally...
Recursive relations for objects of statistical interest have long been important computation, and they remain so even with hugely improved computing power. Such recursions are frequently derived by exploiting between generating functions. For example, the top-order zonal polynomials that occur in much distribution theory under normality can be recursively related to other (easily computed) symmetric functions (power-sum elementary functions; Ruben, 1962, Annals Mathematical Statistics 33,...
Abstract We give a classification of all the C *-algebras Morse-Smale flows on closed two-manifolds, and determine relation between invariants dynamical systems topological *-algebras.
Assets with nonzero alphas are supposed to provide performance improvement relative the benchmark portfolios. However, when mean and covariance matrix of asset returns estimated errors, it is unclear whether can be realized. In this paper, we analyze out-of-sample a sample optimal portfolio constructed based on portfolios set assets alphas. We show that while continues have positive alpha, due estimation fails outperform in terms mean-variance utility for windows typically used literature....
Compared with hesitant fuzzy linguistic term set (HFLTS), double hierarchy (DHHFLTS) has a second set, which is detailed supplementary of each included in the first set. Thus, DHHFLTS can express more complex and sufficient evaluation information than HFLTS. To solve multiple attribute group decision making (MAGDM) problems assessment values alternatives preference relations between are denoted by elements, this paper extends traditional LINMAP method under environment. A practical example...
A case study has been conducted to substantiate the effects of lockdown imposed on Uusimaa area in Finland. In particular, aims find out if mitigated spread coronavirus from other parts The shows that after was imposed, it took approximately two weeks before daily count new COVID-19 cases outside reached its peak and started decrease. phenomenon aligns with findings relevant studies a curve diagnosed infection occurs 14 18 days lockdown. It also emerges lifting caused immediate outflowing...
Nitrogen-vacancy (NV) centers show great potentials for nanoscale bio-sensing and bio-imaging. Nevertheless, their envisioned bio-applications suffer from intrinsic background noise due to unavoidable light scattering autofluorescence in cells tissues. Herein, we develop a novel all-optical modulated imaging method via physically-enabled classifier, on-demand direct access NV fluorescence at pixel resolution while effectively filtering out noise. Specifically, can be optically exhibit...
In [Con2] Connes introduced cyclic cohomology HC * ( A ) for an associative algebra . When is a complex he constructed Chern character p -summable Fredholm modules over taking values in ). As very special case, when X closed C ∞ -manifold and = ), this construction recovers the usual character, which rational isomorphism from K -homology 0 to , even dimensional deRham homology of
This paper conducts an in-depth study on the construction of parallel corpus for English translation teaching through computer-aided software, and this adopts a combination statistics analysis to portray system. In statistics, we carried out detailed data translated text original with help software find linguistic characteristics areas that can be improved from perspective statistics. After that, based frequency, mean value, grading multiplication analysis, carry qualitative movie subtitle...
We present the analytic foundation of a unified B-D-F extension functor <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper E x t Subscript tau"> <mml:semantics> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi>Ext</mml:mi> <mml:mi>τ<!-- τ --></mml:mi> </mml:msub> </mml:mrow> <mml:annotation encoding="application/x-tex">{\operatorname {Ext} _\tau }</mml:annotation> </mml:semantics> </mml:math> </inline-formula> on category...
By using the theory of groupoid equivalence P. S. Muhly, J. N. Renault and D. Williams (cf. [<bold>5, 7</bold>]), we identify relation between <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper C Superscript asterisk"> <mml:semantics> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mi>C</mml:mi> <mml:mo>∗<!-- ∗ --></mml:mo> </mml:msup> </mml:mrow> <mml:annotation encoding="application/x-tex">{C^*}</mml:annotation>...
The application of object-oriented design patterns in transient simulation program for distributed generation systems and micro-grid is introduced this paper, such as factory method pattern, adapter strategy pattern singleton pattern. Taking the advantages design, low coupling between modules well high cohesion within module are achieved have applied program. theory makes software more flexible extensible to functions. universality integration methods described paper proposes a reference...
In 1957 J. Dixmier raised the following question: find a CCR C*-alge- bra which does not admit any finite composition series (Ip), 0 1.
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Objective To investigate the changes of miR-301a and its host gene expression SKA2 in LNCaP prostate cancer xenografts castrated nude mice.Methods cells were inoculated subcutaneously mice to establish xenograft models human cancer.When tumor volume grew 200 mm3,the randomly divided into following 4 groups(n =6): 2 groups surgical castration,the other as control groups.The growth those xnografts was observed weekly a curve drawn.A point time during process tumor-regressing selected when...