A5101830717- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Protease and Inhibitor Mechanisms
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Neurological Disease Mechanisms and Treatments
- Folate and B Vitamins Research
- Retinal Development and Disorders
- Acute Myeloid Leukemia Research
- Cancer-related Molecular Pathways
- Beetle Biology and Toxicology Studies
- Cancer, Lipids, and Metabolism
- Melanoma and MAPK Pathways
- Connective tissue disorders research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Molecular Biology Techniques and Applications
- Carcinogens and Genotoxicity Assessment
- Herpesvirus Infections and Treatments
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2023
Hunan University of Technology
2018-2022
Affiliated Hospital of Qingdao University
2021
Qingdao University
2021
Nantong University
2020
Jingzhou Central Hospital
2018-2020
Yangtze University
2018-2020
North China University of Science and Technology
2020
Second People's Hospital of NanTong
2020
Air pollution has been classified as Group 1 carcinogenic to humans, but the underlying tumorigenesis remains unclear. In Xuanwei City of Yunnan Province, lung cancer incidence is among highest in China attributed severe air generated by combustion smoky coal, providing a unique opportunity dissect carcinogenesis pollution. Here we analyzed somatic mutations 164 non-small cell cancers (NSCLCs) from and control regions (CR) where coal was not used. Whole genome sequencing revealed mean 289...
The mir-17-92 cluster consists of six mature miRNAs and is implicated in diverse human cancers by targeting mRNAs involved distinct pathways that either promote or inhibit carcinogenesis. However, the molecular mechanism underlying cluster-mediated pro-tumorigenic anti-tumorigenic effects has not been clearly elucidated prostate cancer. In present study, role aspects cancer cells thoroughly investigated. Forced introduction into androgen-independent DU145 evidently promoted cell growth due...
Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors that are harmful to human health. Increasing evidence has underscored critical role competitive endogenous RNA (ceRNA) regulatory networks among various cancers. However, complexity and behavior characteristics ceRNA network in HCC were still unclear. In this study, we aimed clarify a phosphatase tensin homolog (PTEN)-related identify potential prognostic markers associated with HCC. The expression profiles three RNAs...
MicroRNAs (miRNAs or miRs) play an important role in the tumorigenesis and progression of breast cancer. However, function miR‑28‑5p cancer migration has yet to be determined. In present study, Human MicroRNA Expression Database (HMED) analysis revealed that expression level was significantly lower tissue than normal tissue. Kaplan‑Meier plotter (KMPLOT) low associated with a poor survival addition, reverse transcription‑quantitative PCR (RT‑qPCR) cell lines compared human mammary...
Lung cancer is the world’s highest morbidity and mortality of malignant tumors, with lung adenocarcinoma (LUAD) as a major subtype. The competitive endogenous RNA (ceRNA) regulative network provides opportunities to understand relationships among different molecules, well mechanisms them in order investigate whole transcriptome landscape pathology. We designed this work explore role key oncogene, MYC, pathogenesis LUAD, study aims identify important long noncoding (lncRNA)-microRNA (miRNA)-...
Acute myeloid leukemia (AML) is a fatal hematopoietic malignancy with poor clinical outcomes. To determine whether the expression of long non‑coding (lnc)RNA zinc finger E‑box binding homeobox 2 (ZEB2) antisense RNA 1 (ZEB2‑AS1) associated outcomes, its was analyzed in retrospective cohort 62 AML and 10 non‑malignant cases. The results revealed that ZEB2‑AS1 lncRNA notably high closely adverse outcomes cases compared cases, based on either modified Medical Research Council or European...
BACKGROUND:Cerebral ischemia-reperfusion injury is a form of serious nervous system injury. Activation the PI3K/Akt pathway can effectively relieve cerebral miR-214 target and inhibit expression PTEN, thereby alleviating its inhibitory effect on pathway. Moreover, lncRNA NEAT1 was reported to affect proliferation metastasis tumor cells by targeting suppressing miR-214. However, whether affects ischemia-reperfusion-induced damage regulating miR-214/PTEN/PI3K/Akt unclear. MATERIAL AND...
Abstract Deregulation of microRNAs (miRNAs) has been implicated in drug resistance various types cancers, including malignant melanoma (MM). MiR‐488‐3p reported as a tumor suppressor several cancers. However, the exact expression patterns miR‐488‐3p and precise molecular mechanisms underlying its role MM remain largely unknown require further investigation. In this study, we demonstrated that is significantly downregulated clinical specimens cell lines. Ectopic resulted markedly increased...
MicroRNAs (miRNAs) may regulate diverse biological processes and play an important role in cancer. And MiRNAs have been proposed as a useful tool for lung cancer diagnosis therapeutics The purpose of the present study was to investigate association among expression level mature miR-200b-5p peripheral blood risk clinic pathological characteristics. This case-control included 24 patients with 12 healthy controls. MiR-200b deleted using real-time PCR. miR-200b normal controls significantly...
Lung adenocarcinoma (LUAD) is the leading cause of cancer deaths worldwide, and effective biomarkers are still lacking for early detection prognosis prediction. Here, based on gene expression profiles LUAD patients from The Cancer Genome Atlas (TCGA), 806 long non-coding RNAs (lncRNAs), 122 microRNAs (miRNAs) 1269 mRNAs associated with CDK1 were identified. regulatory axis LINC00460/LINC00525-hsa-mir-338-FAM111B/ZWINT was determined according to correlation between patient prognosis....
Aberrant activation of GTPases is common in cervical cancer, and their proper biological functions largely depend on a post-translational modification termed prenylation. Simvastatin cholesterol-lowering drug via inhibiting HMG-CoA reductase, thereby protein In this study, we show that simvastatin selectively inhibits proliferation induces apoptosis cancer cells while sparing normal epithelial cells. This achieved by depleting geranylgeranyl pyrophosphate, prenylation, decreasing activities...
Purpose: This study aimed to investigate the effect of ethylacetate extract from Tetrastigma hemsleyanum (EET) on proliferation and apoptosis HepG2 SMMC-7721 cells determine underlying mechanisms. Materials methods: were cultured in vitro until exponential growth phase then treated with different concentrations EET for 24 h. We performed a colony forming assay ability, CCK8 detect cell proliferation, Annexin V–FITC/PI double staining analyze apoptosis, Western blot measure protein expression...
Clear cell renal carcinoma (ccRCC) is a common malignant kidney tumor, the pathogenesis of which remains unclear. The aim present study was to investigate whether caspase-10, matrix metalloproteinase-9 (MMP-9) and total laminin (LM) were involved into ccRCC. levels MMP-9 LM analyzed by ELISA in tumor tissues adjacent non-malignant 27 patients with results revealed that caspase-10 significantly higher than those (P<0.05). lower (P<0.01). no statistical difference (P=0.757). Additionally,...
Objective: To explore the effect and mechanism of over-expression miR-17-92 gene cluster on biological characteristics prostate cancer cells. Methods: DU145 cells were transfected with expression plasmid clones stable ectopic overexpression established. The cell viabilities DU145-17-92 DU145-control monitored by xCELLigence system. Cell proliferation apoptosis analyzed Ki-67 terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. cycle was detected flow cytometry....