A5103000527- Infective Endocarditis Diagnosis and Management
- Actinomycetales infections and treatment
- Diphtheria, Corynebacterium, and Tetanus
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cancer-related molecular mechanisms research
- Cardiac Imaging and Diagnostics
- Bacterial Identification and Susceptibility Testing
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Urinary Tract Infections Management
- Essential Oils and Antimicrobial Activity
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Venous Thromboembolism Diagnosis and Management
- RNA regulation and disease
- Piperaceae Chemical and Biological Studies
- PARP inhibition in cancer therapy
- Plant Toxicity and Pharmacological Properties
- Immune cells in cancer
- Streptococcal Infections and Treatments
Jinan University
2025
First Affiliated Hospital of Jinan University
2025
Jilin University of Chemical Technology
2017-2024
Hunan Normal University
2018-2024
Hunan Provincial People's Hospital
2014-2024
Qilu Hospital of Shandong University
2018-2023
Don Mariano Marcos Memorial State University
2022
Inner Mongolia Electric Power (China)
2019
Hunan Provincial Center for Disease Control and Prevention
2018
Shougang Institute of Technology
2013
Usually, 18-48 h are needed for the identification of microbial pathogens causing urinary tract infections (UTIs) by urine culture. Moreover, antimicrobial susceptibility testing (AST) takes an additional 18-24 h. Rapid and AST allow fast precise treatment. The objective this study was to shorten time diagnosis UTIs combining pathogen screening through flow cytometry, matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS), using VITEK 2 system direct...
Resveratrol (RES) protects myocardial cells from hypoxia/reoxygenation (H/R)-caused injury. However, the mechanism of this effect has not been clarified. Thus, in study, we aimed to determine whether RES attenuates H/R-induced cell necroptosis by inhibiting tumor necrosis factor-alpha (TNF-α)/receptor-interacting protein kinase 1 (RIP1)/RIP3/mixed-lineage domain-like (MLKL) signaling pathway. Rat ischemia/reperfusion (I/R) models and H/R-injured were constructed. Our study showed that H/R...
Ginsenoside-Rg1 (G-Rg1), a saponin that is primary component of ginseng, effective against inflammatory diseases. The P2X purinoceptor 7 (P2X7) receptor an ATP-gated ion channel predominantly expressed in immune cells and plays key role processes. We investigated the G-Rg1 sepsis-related cardiac dysfunction underlying mechanism involving regulation P2X7 receptor. detected cell viability, cytotoxicity, cellular reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP) with...
Purpose: To investigate the therapeutic efficacy of BEZ235, a dual PI3K/mTOR inhibitor, in suppressing pathological neovascularization an oxygen-induced retinopathy (OIR) mouse model and explore role cyclin D1 endothelial cell cycle regulation. Methods: Single-cell RNA sequencing was performed to analyze gene expression cell-cycle alterations retinal cells under normoxic OIR conditions. The effects BEZ235 on human umbilical vein (HUVECs) microvascular (HRMECs) were evaluated by assessing...
Purpose: Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute progression. In our study, we aimed investigate the expression clinical pertinence serine peptidase inhibitor, Kunitz type 1 RNA1 ( SPINT1-AS1 ) CRC. Materials methods: The levels corresponding sense transcript SPINT1 mRNA were analyzed 150 pairs CRC tissues adjacent normal (AN)...
The current tumor node metastasis ( TNM ) staging system is inadequate for identifying high‐risk gastric cancer GC patients. Using a systematic and comprehensive‐biomarker discovery validation approach, we attempted to build micro RNA (miRNA)‐recurrence classifier MRC improve the prognostic prediction of . We identified 312 differentially expressed mi s in 446 tissues compared 45 normal controls by analyzing high‐throughput data from Cancer Genome Atlas TCGA ). Cox regression model,...
Rapid identification and determination of the antibiotic susceptibility profiles infectious agents in patients with bloodstream infections are critical steps choosing an effective targeted for treatment. However, there has been minimal effort focused on developing combined methods simultaneous direct bacteria positive blood cultures. In this study, we constructed a lysis-centrifugation-wash procedure to prepare bacterial pellet from cultures, which can be used directly by matrix-assisted...
Importance Parenteral enoxaparin is a preferred anticoagulant used in the acute phase for patients with coronary syndrome (ACS). The safety and efficacy of short-term low-dose rivaroxaban this clinical setting remain unknown. Objective To compare vs ACS. Design, Setting, Participants This multicenter, prospective, open-label, active-controlled, equivalence noninferiority trial was conducted from January 2017 through May 2021 6-month follow-up at 21 hospitals China. included ACS missing...
Abstract Background: Prostaglandin-E1 (PGE1) is a potent vasodilator with anti-inflammatory and antiplatelet effects. However, the mechanism by which PGE1 contributes to amelioration of cardiac injury remains unclear. Methods: The present study was designed investigate how protects against hypoxia/reoxygenation (H/R)-induced injuries regulating microRNA-21-5p (miR-21-5p) fas ligand (FASLG). Rat H9C2 cells isolated primary cardiomyocytes were cultured under hypoxic conditions for 6 h (6H,...
microRNAs (miRs) are essential in the development of heart failure. The aim this study is to investigate effect microRNA-330 (miR-330) on left ventricular remodeling via TGF-β1/Smad3 signaling pathway by targeting sex-determining region Y (SRY) mice with myocardial ischemia-reperfusion injury (MIRI). Differentially expressed gene (DEG) (IR) was screened out and miR that targeted DEG also predicted verified. A model MIRI established detect expression miR-330, SRY, transforming growth factor-β...
The levels of human epididymis protein 4 (HE4) is associated not only with the prognosis patients acute heart failure (AHF), but also chronic kidney disease (CKD). Our study aims to understand prediction value HE4 on in AHF combined CKD.
Citrus reticulata cv. Shatangju peel essential oil (CrspEo), with three major components D-limonene (88.15%), γ-terpinene (4.59%) and β-myrcene (2.62%), possessed antioxidant activities DPPH ABTS+ radical scavenging the IC50 (concentration of CrspEo 50% radical) 9.87±0.12% 0.48±0.02%, respectively. Meanwhile, showed antimicrobial activity in suppressing growth Bacillus pumilus, subtilis, Candida albicans, Escherichia coli, Staphylococcus aureus, Saccharomyces cerevisiae Minimum Inhibitory...
The mts locus in salt-tolerant Myxococcus fulvus HW-1 was found to be critical for gliding motility, fruiting-body formation, and sporulation. homologous genes xanthus are also important social motility development. were determined involved cell-cell cohesion both myxobacterial species.
The emergence of Acinetobacter baumannii infections as a significant healthcare concern in hospital settings, coupled with their association poorer clinical outcomes, has prompted extensive investigation into novel therapeutic agents and innovative treatment strategies. Proguanil chlorhexidine, both categorized biguanide compounds, have displayed efficacy antimalarial topical antibacterial agents, respectively. In this study, we conducted an to assess the effectiveness combining proguanil...
To investigate a strategy for ultra-low volume contrast percutaneous coronary intervention (PCI) with the aims of preserving renal function and observing 90-day clinical endpoint in patients non-ST-elevated myocardial infarction (non-STEMI) chronic kidney disease (CKD).The feasibility, safety, utility PCI radio-contrast medium non-STEMI CKD are unknown.A total 29 (estimated glomerular filtration rate [eGFR] ≤60 ml/min/1.73 m2 ) were included. Ultra-low was performed after minimal angiography...