A5100766593- Sepsis Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Inflammasome and immune disorders
- Phytochemicals and Antioxidant Activities
- Ginseng Biological Effects and Applications
- Phytochemistry and Biological Activities
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Pancreatitis Pathology and Treatment
- Hydrogen's biological and therapeutic effects
- PARP inhibition in cancer therapy
- Heat shock proteins research
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Genetics, Aging, and Longevity in Model Organisms
- Inflammatory Bowel Disease
- Biochemical and biochemical processes
- RNA modifications and cancer
- Anesthesia and Neurotoxicity Research
Hunan Provincial People's Hospital
2016-2025
Hunan Normal University
2019-2025
Sichuan University
2020-2025
Zunyi Medical University
2025
Chinese Academy of Sciences
2008-2024
China University of Mining and Technology
2024
Traditional Chinese Medicine Hospital of Kunshan
2024
Shanghai University of Traditional Chinese Medicine
2024
Shanghai Institute of Materia Medica
2024
Nanjing University of Chinese Medicine
2024
Lignins are complex phenylpropanoid polymers mostly associated with plant secondary cell walls. arise primarily via oxidative polymerization of the three monolignols, p -coumaryl, coniferyl, and sinapyl alcohols. Of two hydroxycinnamyl alcohols that represent incompletely methylated biosynthetic products (and not usually considered to be monolignols), 5-hydroxyconiferyl alcohol is now well established as incorporating into angiosperm lignins, but incorporation caffeyl has been shown. We...
Alzheimer’s disease (AD) is the most common cause of dementia among senior citizen. Ganoderma lucidum triterpenoids (GLTs) have nutritional health benefits and has been shown to promote longevity, but a protective effect GLTs on AD damage not yet reported. The objective this research was elucidate phylactic model mice cells explore its underlying mechanisms. Morris water maze (MWM) test conducted detect changes in cognitive function mice. Hematoxylin-eosin (HE) staining applied observe...
Abstract Pigs are valuable large animal models for biomedical and genetic research, but insights into the tissue- cell-type-specific transcriptome heterogeneity remain limited. By leveraging single-cell RNA sequencing, we generate a multiple-organ transcriptomic map containing over 200,000 pig cells from 20 tissues/organs. We comprehensively characterize of in tissues identify 234 cell clusters, representing 58 major types. In-depth integrative analysis endothelial reveals high degree...
Abstract The Hedyotis diffusa – Scutellaria officinalis pair (HD–SB) has therapeutic effects on a variety of cancers. Our study was to explore the mechanism HD–SB in treatment hepatocellular carcinoma (HCC). A total 217 active ingredients and 1196 HCC-related targets were reserved from TCMSP SwissTarget Prediction database, we got 63 intersection GeneCards. We used Venn diagram, Cytoscape found that three core quercetin, luteolin, baicalein. PPI analysis showed TP53, CDK2, XPO1, APP....
Background & Aims: Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that has been used in the operations involving aortic arch and brain aneurysm for decades. We previous showed DHCA treated rats developed significant oxidative stress apoptosis neurons. here intend to investigate protective effect of hydrogen against stress-induced cell injury involved mechanisms using an vitro experimental model hypoxia/reoxygenation (H/R) on HT-22 cells. Methods: The H/R...
Ginsenoside-Rg1 (G-Rg1), a saponin that is primary component of ginseng, effective against inflammatory diseases. The P2X purinoceptor 7 (P2X7) receptor an ATP-gated ion channel predominantly expressed in immune cells and plays key role processes. We investigated the G-Rg1 sepsis-related cardiac dysfunction underlying mechanism involving regulation P2X7 receptor. detected cell viability, cytotoxicity, cellular reactive oxygen species (ROS) levels, mitochondrial membrane potential (MMP) with...
Severe acute pancreatitis associated with lung injury (SAP-ALI) is a critical condition high mortality rate. Investigating the pathogenesis of SAP-ALI and developing effective treatments are urgently needed. Chaihuang Qingfu Pills (CHQF), traditional Chinese medicine modified from Qingyi Decoction, has been approved for treating (AP). However, its role in underlying mechanisms remain unclear. 92 AP patients were enrolled to observe protective effect CHQF on AP-ALI. L-arginine was used...
<title>Abstract</title> <bold>Background: </bold>Severe acute pancreatitis (SAP) patients in intensive care units (ICU) frequently experience multidimensional discomfort, yet validated tools like the Chinese version of Inconforts des Patients de REAnimation (IPREA-China) remain underutilized this population. Guided by Kolcaba’s comfort theory, study aimed to fill gap understanding and managing discomfort SAP patients. <bold>Objective: </bold>To assess levels using IPREA-China, identify...
The homeostatic balance of hepatic glucose uptake and production is exquisitely controlled by hormonal signals during feed-fast cycles. FoxO1, a transcription factor that functions in the regulation homeostasis, undergoes posttranslational modifications, such as acetylation, response to signals, yet mechanism remains poorly elucidated. Through expression profiling 324 co-factors CBP, well-known acetyl-transferase we identify Ets1 modulator FoxO1 acetylation highly associated with Mechanistic...
ObjectiveSepsis is the leading course of morbidity and mortality in critically ill patients. This study aimed to evaluate predictive value platelet aggregation for patients with sepsis. In addition, relationship between impaired mitochondria was explored.MethodThis a prospective, observational cohort study. The rate response adenosine diphosphate (ADP) assessed. primary outcome 28-day mortality. Platelet mitochondrial parameters, including triphosphate(ATP), membrane potential (MMP)...
Pods of the vanilla orchid (Vanilla planifolia) accumulate large amounts flavor compound vanillin (3-methoxy, 4-hydroxy-benzaldehyde) as a glucoside during later stages their development. At earlier stages, developing seeds within pod synthesize novel lignin polymer, catechyl (C) lignin, in coats. Genomic resources for determining biosynthetic routes to these compounds and other components V. planifolia are currently limited. Using next-generation sequencing technologies, we have generated...
Research in the laboratory has shown that lyophilized black raspberries (BRB) significantly inhibit N-nitrosomethylbenzylamine (NMBA)-induced esophageal squamous cell carcinogenesis rats. The objective of present study is to characterize underlying mechanism(s) anti-cancer action BRB this preclinical animal model focusing on oxidative stress and its related oncogenic signaling pathways. Esophageal epithelial tissues were collected assessed for markers nuclear factor κB (NFκB)...
An alternate conformation is found for the major antibody target on hepatitis C virus to aid in rational vaccine design.
The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities that humans. However, cellular compositions (PB) remain elusive. Here we investigated single-nucleus transcriptomic profiles five regions PB (frontal lobe, parietal temporal occipital and hypothalamus) identified 21 cell subpopulations. cross-species comparison mouse hypothalamus revealed shared specific gene expression patterns at single-cell resolution. Furthermore, types...
Endothelial glycocalyx loss is integral to increased pulmonary vascular permeability in sepsis-related acute lung injury. Protectin conjugates tissue regeneration 1 (PCTR1) a novel macrophage-derived lipid mediator exhibiting potential anti-inflammatory and pro-resolving benefits. PCTR1 was administrated intraperitoneally with 100 ng/mouse after lipopolysaccharide (LPS) challenged. Survival rate function were used evaluate the protective effects of PCTR1. Lung inflammation response observed...
The immune response of brain cells to invading bacteria in vivo and the mechanism used by pathogenic escape surveillance remain largely unknown. It is believed that microglia eliminate phagocytosis based on vitro data. Here we find a small percentage engulf neonatal meningitis-causing Escherichia coli (NMEC), but more are activated produce tumor necrosis factor alpha (TNFα), which activates astrocytes secrete complement component 3 (C3) involved anti-bacterial activity. To evade activity...