A5067179967- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Dental Implant Techniques and Outcomes
- Diet, Metabolism, and Disease
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Heat shock proteins research
- Cerebrovascular and Carotid Artery Diseases
- S100 Proteins and Annexins
- Eicosanoids and Hypertension Pharmacology
- Transplantation: Methods and Outcomes
- Silicon Effects in Agriculture
- Pacific and Southeast Asian Studies
- Oropharyngeal Anatomy and Pathologies
- Hormonal Regulation and Hypertension
- RNA regulation and disease
- Autopsy Techniques and Outcomes
- Neonatal Health and Biochemistry
- Diet and metabolism studies
- Hippo pathway signaling and YAP/TAZ
- Freezing and Crystallization Processes
- Sunflower and Safflower Cultivation
- Pulmonary Hypertension Research and Treatments
Hunan Normal University
2019-2025
Hunan Provincial People's Hospital
2016-2025
People's Liberation Army No. 150 Hospital
2024
Chinese People's Liberation Army
2020-2024
Yahoo (United Kingdom)
2024
Chinese PLA General Hospital
2014-2017
Xiangya Hospital Central South University
2017
Central South University
2017
Hubei University of Chinese Medicine
2014
Severe acute pancreatitis associated with lung injury (SAP-ALI) is a critical condition high mortality rate. Investigating the pathogenesis of SAP-ALI and developing effective treatments are urgently needed. Chaihuang Qingfu Pills (CHQF), traditional Chinese medicine modified from Qingyi Decoction, has been approved for treating (AP). However, its role in underlying mechanisms remain unclear. 92 AP patients were enrolled to observe protective effect CHQF on AP-ALI. L-arginine was used...
ABSTRACT Signal transducers and activators of transcription 1 (STAT1) exhibits tumor‐suppressor properties by inhibiting oncogenic pathways promoting tumor immunosurveillance. MicroRNAs, a group non‐coding endogenous ones, may regulate gene expression plays specific roles in tumorigenesis. Recently, miR‐181a has been reported to be associated with poor prognosis colorectal cancer (CRC). Using human cell lines, we demonstrated that STAT1 suppresses both LoVo SW480 growth down‐regulating...
Neuron navigator 2 (NAV2) encodes a member of the neuron gene family, which plays role in tumorigenesis and cell migration. However, prognostic value NAV2 expression colorectal cancer (CRC) patients potential pathway through promotes migration invasion CRC lines is poorly understood. The level was detected tissues from two different cohorts by immunohistochemistry, qRT-PCR Western blotting; correlation between clinicopathological characters analyzed, analyzed using Cox regression model. with...
Thioredoxin domain‑containing 5 (TXNDC5) is reportedly overexpressed in colorectal cancer (CRC) and therefore considered an oncogene. However, the role of TXNDC5 CRC tumorigenesis remains unclear. The present study aimed to explore vitro vivo under hypoxic normoxic conditions. Analyses patient tissue samples revealed a positive association between expression hypoxia‑inducible factor‑1α (HIF‑1α) or TNM stage CRC. In addition, correlation levels HIF‑1α was observed tissues. Furthermore,...
Oxidative stress is the main cause of acute myocardial infarction (AMI), which related to disorder regulation Bmal1 on redox state. HSPB1 form homologous‐oxidized (homooxidized HSPB1) resist oxidative damage via S‐thiolated modification. However, it still unclarified whether there an interaction between circadian clock and in injury. A total 118 AMI patients admitted treated our hospital from Sep. 2019 2020 were selected detect plasma expression We divided into three subgroups: morning‐onset...
Objective To evaluate the beneficial effects of hydroxysafflor yellow A (HSYA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats, and to investigate main pathophysiological mechanism HSYA preventing development MCT-induced PAH. Methods Four groups (control, control with treatment, MCT-exposed, MCT-exposed treatment) were evaluated at day 28 following MCT exposure. Haemodynamic measurements, right ventricular hypertrophy, morphometry, inflammatory cytokines oxidant...
The purpose of this meta-analysis was to assess and compare clinical outcomes short implants versus long placed in conjunction with a bone augmentation procedure.The eligible studies were searched from PubMed, Embase, Springer link, the Cochrane library databases up 23 January 2015. Prosthesis failures, implant complications, marginal loss measured. pooled weighted mean difference (WMD) or risk ratios (RRs) their 95% confidence intervals (CIs) used measure effect size continuous variables...
Abstract Background: Texture features were the intrinsic properties of human tissues and could efficiently detect subtle functional changes involved tissue. The pathologic lateral pterygoid muscle (LPM) significantly correlated with temporomandibular disc displacement. However, occult LPM not be detected by naked eye on medical images. current study was aimed to evaluate in patients disorders (TMDs) using texture analysis. Methods: Twenty-nine TMD performed magnetic resonance (MR) imaging a...
Rationale: Leukoencephalopathy with calcifications and cysts (LCC) is an uncommon entity characterized by edematous leukoencephalopathy, cerebral calcifications, parenchymal cysts. Due to its rarity, the clinical, radiological, histopathological features have yet be well elucidated. Patient concerns: The first case a 35-year-old female who was asymptomatic. A giant intracranial cyst incidentally detected radiologically, it slowly growing in recent 10 years. second 20-year-old presented...
This study aims to explore the molecular mechanism of N6-methyladenosine (m6A) modification-related long noncoding RNA (lncRNA)–microRNA (miRNA)–messenger (mRNA) network in regulating autophagy and affecting occurrence development acute pancreatitis (AP). RNA-seq datasets related AP were obtained from Gene Expression Omnibus (GEO) database merged after batch effect removal. lncRNAs significantly m6A AP, namely candidate lncRNA, screened by correlation analysis differential expression...
This study aimed to provide feasible suggestions for intraventricular injection of tigecycline treat intractable Acinetobacter baumannii intracranial infections by studying its pharmacokinetics/pharmacodynamics and neurotoxicity.A simple reliable two-dimensional high-performance liquid chromatography (2D-HPLC) method was used determine concentration. The pharmacokinetics (PK) in cerebrospinal fluid (CSF) investigated performing therapeutic drug monitoring (TDM). pharmacodynamics (PD)...
Our aim is to investigate the significance of electrogastrography in treatment esophageal variceal hemorrhage with octreotide. Electrogastrography was performed patients before and during consisting various doses octreotide (25 ug h(-1) group 50 group). The dominant power its relationship hemostatic efficacy were evaluated. Dominant decreased significantly (P < 0.05). reduction amplitude larger than 25 0.05), it correlated treatment. We conclude that can result a significant decrease power,...
In this study, we investigated the difference in risk factors between 2 diseases, aiming to further clarify who needs do ischemic cerebrovascular disease (ICVD)-related screening among coronary artery (CAD) patients.
To analyze the predictors of successful weaning off extracorporeal membrane oxygenation (ECMO) after cardiopulmonary resuscitation (ECPR).The clinical data 56 patients with cardiac arrest who underwent ECPR in Hunan Provincial People's Hospital (the First Affiliated Normal University) from July 2018 to September 2022 were retrospectively analyzed. According whether ECMO was successfully off, divided into group and failed group. The basic data, duration conventional (CCPR, time ECMO), ECMO,...