A5083607178- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Infections and bacterial resistance
- Antibiotic Use and Resistance
- Enterobacteriaceae and Cronobacter Research
- Microbial Metabolism and Applications
- Genomics and Phylogenetic Studies
- Bacterial Infections and Vaccines
- Plant Pathogenic Bacteria Studies
- Molecular Biology Techniques and Applications
- Nosocomial Infections in ICU
- Microbial Applications in Construction Materials
- Antimicrobial Resistance in Staphylococcus
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- Pediatric health and respiratory diseases
- Malaria Research and Control
- Bone and Dental Protein Studies
- Vector-Borne Animal Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Actinomycetales infections and treatment
- Bacterial biofilms and quorum sensing
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Immunotherapy and Immune Responses
Hunan Provincial People's Hospital
2009-2024
Hunan Normal University
2017-2024
ABSTRACT Carbapenem-resistant Enterobacteriaceae (CRE) infection is highly endemic in China, but estimates of the burden are lacking. We established incidence CRE from a multicenter study that covered 25 tertiary hospitals 14 provinces. cases defined as carbapenem-nonsusceptible Citrobacter freundii , Escherichia coli Enterobacter cloacae or Klebsiella pneumoniae infections during January to December 2015 were collected and reviewed medical records. Antimicrobial susceptibility testing...
Carbapenem-resistant Enterobacteriaceae (CRE) strains are a major threat to global health. The development of effective control measures requires more detailed phenotypic and genotypic characterization CRE. CRE isolates were collected from 65 hospitals in 25 provinces across China between January 1, 2012, December 31, 2016. characterized by antimicrobial susceptibility testing multilocus sequence typing. Genes encoding carbapenemases, mobilized colistin resistance (mcr-1), β-lactamases...
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been increasingly reported in China. Here, a multicentre, longitudinal surveillance study on CR-hvKP is described.We retrospectively investigated carbapenem-resistant K. (CRKP) 56 centres across China during 2015-17 and screened the virulence genes (iucA, iroN, rmpA rmpA2) for presence of plasmids. Hypermucoviscosity, serum killing Galleria mellonella lethality experiments were conducted to identify among strains with...
Due to the severe drug resistance situation of Gram-negative bacteria, especially enterobacter, relatively little attention has been paid changes in Gram-positive bacteria species and resistance. Therefore, this study analyzed prevalence a general tertiary-care hospital from 2014 2021, order discover distribution that cannot be easily identified, inform clinicians their respective regions when selecting antimicrobial agents, provide basis for diagnosis bacterial infection, comprehensive...
Purpose: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is closely related to respiratory tract infection. The aim of this study was investigate the clinical features and prognostic factors CRKP-induced pneumonia in acute exacerbation chronic obstructive pulmonary disease (AECOPD) patients. Methods: A single-centre, retrospective case-control on COPD patients hospitalized for conducted from January 1, 2016, December 31, 2022. mortality rate due investigated. were divided into pneumonic...
Abstract Background The purpose of our study is to analyze the microbiological and clinical characteristics carbapenem‐resistant hypervirulent Klebsiella pneumoniae (CR‐hvKP) that causes nosocomial infection. Methods We collected K . (CRKP) strains caused infection in a hospital China relevant data. characterized these for their antimicrobial virulence‐associated phenotype genotype analyzed clonal relatedness. screened compared them with non‐hypervirulent strains. Results retrospectively 62...
Background Gram-negative bacilli are one of the most common causes various infections in clinical. The emergence and global spread multi-drug resistant gram-negative has become a major challenge public health field. Methods A total 51,189 non-repetitive strains were isolated clinical settings. antimicrobial susceptibility testing was conducted by using automated VITEK 2 compact system matched AST test card, complemented disk diffusion method. results interpreted CLSI. Rates MDR XDR...
This study was to investigate the prevalence of mcr-1-positive Enterobacteriaceae (MPE) in intra-abdominal infections (IAIs), urinary tract (UTIs), and lower respiratory (LRTIs) China. A total 6,401 isolates were collected consecutively from IAI, UTI, LRTI patients 19 hospitals across mainland China during 2014-2016. MPE screened by PCR detection for mcr gene. The resistance profiles tested antimicrobial susceptibility test. All characterized pulsed-field gel electrophoresis (PFGE),...
Background/Aims: Spinal tuberculosis (TB) is a common and dangerous form of extrapulmonary TB with unclear mechanisms in its occurrence progression. This study investigated the clinical significances bone morphogenetic protein-4 (BMP-4), osteopontin (OPN), vitamin D receptor (VDR) gene polymorphism, mRNA protein expression spinal patients. Methods: BMP-4 OPN polymorphisms were detected by direct DNA sequencing, while VDR-FokI analyzed using PCR-RFLP. was measured real-time PCR Western blot,...
This study aimed to provide feasible suggestions for intraventricular injection of tigecycline treat intractable Acinetobacter baumannii intracranial infections by studying its pharmacokinetics/pharmacodynamics and neurotoxicity.A simple reliable two-dimensional high-performance liquid chromatography (2D-HPLC) method was used determine concentration. The pharmacokinetics (PK) in cerebrospinal fluid (CSF) investigated performing therapeutic drug monitoring (TDM). pharmacodynamics (PD)...
Abstract: This case report describes the of a female infant hospitalized for severe pneumonia. During treatment process, various antibiotics are used to treat and prevent further infection. The child had weak physical condition, combined with neuroblastoma, paraneoplastic syndrome, low immune function, leading Tsukamurella tyrosinosolvens was eventually abandoned owing poor prognosis. study aims through medium, dyeing, electron microscope observation, 16s rRNA high-throughput sequencing...
Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) have been a clinically significant pathogen worldwide, but related reports about their virulence features in hospital-acquired infections (HAI) are pretty lacking.Methods CRKP causing HAI were continuously collected 2018 from hospital central China. Isolates identification and antimicrobial susceptibility test done using VITEK-2 compact system or MALDI-TOF MS. String test, multilocus sequence typing, carbapenemase genes,...
Neonatal meningitis is rare but devastating disease. Multidrug-resistant (MDR, multi-drug resistant) bacteria are a major global health risk. We report an Escherichia coli isolate with multiple resistance patterns and unusual serotype (O75) that caused sudden neonatal death. The was resistant to antibiotics other than cefoperazone/sulbactam imipenem, challenging the combination of commonly used in empirical treatment sepsis. Despite aggressive symptomatic supportive infant based on...
Abstract Human infections by environmental bacteria is becoming an increasing problem and has become a matter of great concern due to the adverse effects worldwide. In this study, we reported new pathogen. Isolate GX5518 T was novel Gram-negative, aerobic, non-motile, pleomorphic red-pigmented bacterium, isolated from human wound secretions (GuangXi, People’s Republic China). Growth occurred at pH 6.0–8.0 (optimum, 7.0) 10–37 °C 28–32 °C) with 0–1.5% (w/v) NaCl in R2A agar. Comparative...
Objective To explore the effect of SDF-1 α /CXCR4 on THP-1 cells chemotaxis and influence OX- LDL migration esplsed to SDP-1 α,the OX-LDL in expression CXCR4 cells.THP-1 was examined with transwell permeable supports.THP-1 or withort pretreatde were input upper chambers,SDF-1αwas added low chambers.Number migrated chamber counted after incubation for 10h.CXCR4 mRNA protein revealed by RT-PCR Western blkt respectively incubated different concentrations/time OX-LDL.Results SDF-1αinduced a...