A5103254698- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Antibiotics Pharmacokinetics and Efficacy
- Fungal Infections and Studies
- Urinary Tract Infections Management
- Bacterial biofilms and quorum sensing
- Plant tissue culture and regeneration
- Carcinogens and Genotoxicity Assessment
- Enterobacteriaceae and Cronobacter Research
- Vibrio bacteria research studies
- Nosocomial Infections in ICU
- DNA Repair Mechanisms
- Yeasts and Rust Fungi Studies
Huashan Hospital
2024
Fudan University
2024
First Affiliated Hospital of Harbin Medical University
2020-2023
Harbin Medical University
2020-2023
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been increasingly reported in China. Here, a multicentre, longitudinal surveillance study on CR-hvKP is described.We retrospectively investigated carbapenem-resistant K. (CRKP) 56 centres across China during 2015-17 and screened the virulence genes (iucA, iroN, rmpA rmpA2) for presence of plasmids. Hypermucoviscosity, serum killing Galleria mellonella lethality experiments were conducted to identify among strains with...
Abstract Antimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Surveillance Network (CHINET) was established 2005 to monitor antimicrobial country. This study analyzed CHINET data from teaching hospitals and evaluated trends of AMR 2018 2022. A range 163,636 301,917 isolates obtained per year, majority being Gram-negative bacilli (69.0% 71.8%). The proportion important...
Abstract Invasive diseases caused by the globally distributed commensal yeast Candida tropicalis are associated with mortality rates of greater than 50%. Notable increases azole resistance have been observed in this species, particularly within Asia-Pacific regions. Here, we carried out a genetic population study on 1571 global C. isolates using multilocus sequence typing (MLST). In addition, whole-genome sequencing (WGS) analysis was conducted 629 these strains, comprising 448 clinical...
Abstract Antimicrobial resistance poses a significant threat to global public health, especially for Enterobacterales. In this study, we investigated the distribution and antimicrobial of Enterobacterales in children China Surveillance Network (CHINET) 2015–2021. total, 81,681 strains isolated from were collected period, accounting 50.1% Gram-negative organisms. The most frequently Escherichia coli , Klebsiella spp., Salmonella Enterobacter spp. main sources isolates urine respiratory tract,...
The Chinese Meropenem Surveillance Study (CMSS) was conducted every 2 years from 2010 to 2018 monitor the antimicrobial activity of commonly used agents against nosocomial gram-negative bacilli in China.From 2018, 6,537 were collected 14 teaching hospitals. minimum inhibitory concentrations (MICs) meropenem and other determined using agar dilution broth microdilution methods.Continuous surveillance indicated that, except for Klebsiella pneumoniae, susceptibility Enterobacterales carbapenems...
Monitoring antifungal susceptibility patterns for new or established antifungals is imperative. Antifungal resistance frequent in molds, frequently leading to invasive mold infections (IMIs) immunocompromised patients with high morbidity and mortality. Limited availability of effective treatment IMIs China an enormous challenge. The purpose this study was monitor vitro profiles isolates from China, a particular focus on evaluating isavuconazole (ISA) activity against these isolates,...
Abstract Antimicrobial resistance poses a global threat to human health. Analyzing monitoring data on antimicrobial can assist clinicians in making strategic decisions and promptly identifying outbreaks of antimicrobial-resistant organisms. The China Surveillance Network (CHINET) was established 2004 monitor the trends bacterial epidemiology resistance. In this study, we analyzed distribution changing profiles Enterobacter spp. isolated from 53 hospitals across between 2015 2021 using CHINET...
Calmodulin (CaM), widely distributed in almost all eukaryotic cells, is a major intracellular calcium receptor responsible for mediating the Ca2+ signal to multitude of different enzyme systems and thought play vital role regulation cell proliferative cycle[1,2]. Recently, many studies showed that CaM also present extracellular fluid such as culture media normal body has been reported stimulate proliferation range neoplastic apparently acting an autocrine growth factor[3-11]. In 1988,...