A5101646175- Antibiotic Resistance in Bacteria
- Stroke Rehabilitation and Recovery
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Helicobacter pylori-related gastroenterology studies
- Bacterial Identification and Susceptibility Testing
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Veterinary medicine and infectious diseases
- HIV/AIDS drug development and treatment
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Botulinum Toxin and Related Neurological Disorders
- Virtual Reality Applications and Impacts
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- HIV Research and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Chemical Physics Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Facial Nerve Paralysis Treatment and Research
- Infections and bacterial resistance
- Gut microbiota and health
- Electrochemical sensors and biosensors
- Silicon Nanostructures and Photoluminescence
Huashan Hospital
2015-2025
Fudan University
2015-2025
Gansu Provincial Maternal and Child Health Hospital
2025
Chemical Synthesis Lab
2025
Zhejiang University
2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Huadong Hospital
2021-2023
Northwest A&F University
2022
Jinzhou Medical University
2022
Yangzhou University
2022
Abstract Antimicrobial resistance surveillance systems have been established in China. Two representative national networks are the China Surveillance Network (CHINET) and Resistance System (CARSS), both of which were 2005. For all clinical isolates collected these networks, ratio Gram-negative bacilli to Gram-positive cocci was approximately 7:3 during past 18 years. Generally, a higher antimicrobial profile The prevalence ESBLs Escherichia coli is as high 50%. Acinetobacter...
Abstract Antimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Surveillance Network (CHINET) was established 2005 to monitor antimicrobial country. This study analyzed CHINET data from teaching hospitals and evaluated trends of AMR 2018 2022. A range 163,636 301,917 isolates obtained per year, majority being Gram-negative bacilli (69.0% 71.8%). The proportion important...
Novel β-lactam-β-lactamase inhibitor combinations (BLBLIs) are in clinical development for the treatment of infections caused by carbapenem-resistant and difficult-to-treat resistant (DTR) (defined as resistance to all tested β-lactams fluoroquinolones) Gram-negative bacilli. This study evaluated
Mirror therapy (MT) has been proposed to promote motor recovery post-stroke through activation of mirror neuron system, recruitment ipsilateral pathways, or/and increasing attention toward the affected limb. However, neuroimaging evidence for these mechanisms is still lacking. To uncover underlying mechanisms, we designed a randomized controlled study and used voxel-based whole-brain analysis resting-state fMRI explore brain reorganizations induced by MT. Thirty-five stroke patients were an...
Gold nanoparticle-coated Pluronic-b-poly(L-lysine) nanoparticles (Pluronic-PLL@Au NPs) were synthesized via an easy one-step method and employed as carriers for the delivery of paclitaxel (PTX) in chemo-photothermal therapy, which Pluronic-PLL acts reductant formation AuNPs without need additional reducing agent.The deposition on surface micelles thermal response system followed ultraviolet-visible spectroscopy dynamic light scattering. Calcein-AM MTT assays used to study cell viability...
Chiral benzothiazepines constitute the core structures of many foremost pharmaceuticals with diverse biological activities endowed by their unique scaffolds, which poses a great challenge to organic chemists and pharmaceutical researchers. This review provides concise overview for asymmetric synthesis chiral benzothiazepine derivatives, focusing on advances in catalysis, including metal small-molecule organocatalysis enzymatic catalysis. The catalytic reactions, involving epoxidation,...
Brain-computer interface (BCI) has been regarded as a newly developing intervention in promoting motor recovery stroke survivors. Several studies have performed chronic to explore its clinical and subclinical efficacy. However, evidence subacute was poor, the longitudinal sensorimotor rhythm changes after BCI with exoskeleton feedback were still unclear.Fourteen patients stage recruited randomly allocated group (n = 7) control 7). training applied three times week for 4 weeks. The Fugl-Meyer...
Bimanual cooperation plays a vital role in functions of the upper extremity and daily activities. Based on principle bilateral movement, mirror therapy could provide bimanual training. However, conventional not achieve isolation mirror. A novel paradigm called associated (AMT) was proposed to task-based visual feedback isolating from The study aimed at exploring feasibility effectiveness AMT stroke patients. We conducted single-blind, randomized controlled trial. Thirty-six eligible patients...
Shanghai, in east China, has one of the world's highest burdens Helicobacter pylori infection. While multidrug regimens can effectively eradicate H. pylori, increasing prevalence antibiotic resistance (AR) been recognized by WHO as 'high priority' for urgent need new therapies. Moreover, genetic characteristics AR Shanghai is under-reported. The purpose this study was to determine prevalence, re-substantiate resistance-conferring mutations, and investigate novel elements associated with AR.
As the first-line antimicrobial agent for infection caused by carbapenem-resistant Enterobacterales, ceftazidime-avibactam develops drug resistance during its ever-growing clinical use. In this study, we report multiple novel variants in blaKPC-2-positive Klebsiella pneumoniae from two separate patients their exposure to ceftazidime-avibactam. For one patient, blaKPC-2 gene carried K. mutated into blaKPC-35, blaKPC-78, and blaKPC-33 over same period, while that other patient blaKPC-79...
Ceftazidime-avibactam resistance attributable to the
ABSTRACT The increasing use of ceftazidime-avibactam has led to the emergence a wide range ceftazidime-avibactam-resistant bla KPC-2 variants. Particularly, conventional carbapenemase phenotypic assay exhibited high false-negative rate for In this study, three colloidal gold immunoassays, including Gold Mountainriver CGI test, Dynamiker test and NG-Test CARBA5, GeneXpert Carba-R, were used detect presence its various variants in 42 Klebsiella pneumoniae strains. These strains covered (13/42)...
Carbapenemase detection is essential for the appropriate treatment of CRE infections. Several clinical laboratories have begun using relevant carbapenemase assays such as mCIM (modified carbapenem inactivation method) and eCIM (EDTA method), APB/EDTA method, NG-test Carba 5, GeneXpert Carba-R to detect carbapenemases.
Ceftazidime-avibactam (CZA) is employed for the treatment of infections caused by
Abstract Composite fibrous electrospun membranes based on poly( dl ‐lactide) (PLA) and poly(ε‐caprolactone) (PCL) were engineered to include borate bioactive glass (BBG) for the potential purposes of guided bone regeneration (GBR). The fibers characterized using scanning transmission electron microscopies, which respectively confirmed submicron arrangement successful incorporation BBG particles. Selected mechanical properties evaluated suture pullout test. addition at 10 wt % led similar...
Abstract A palladium‐catalyzed highly stereoselective sulfonylation of vinylethylene carbonates for the precise synthesis structurally diverse ( Z )‐allylic sulfones was achieved with excellent regioselectivity and stereoselectivity / E ratio, up to 99 : 1). This protocol used inexpensive sodium sulfinates as sulfonyl sources construct valuable in good yields. The controlling experiment suggested that hydroxyl proton came from α‐hydrogen sulfone group through 1, 5‐H shift.
Background: Spasticity is common among patients with stroke. Repetitive peripheral magnetic stimulation (rPMS) a painless and noninvasive therapy that promising approach to reducing spasticity. However, the central mechanism of this remains unclear. Changes in cortical activity decreased spasticity after rPMS intervention require further exploration. The aim study was explore electroencephalography (EEG) mu rhythm change decrease Materials methods: A total 32 following stroke were recruited...
Background: Motor attempt and motor imagery (MI) are two common tasks used in brain-computer interface (BCI). They widely researched for rehabilitation patients with hemiplegia. The differences between the (MA) MI of hemiplegia can be to promote BCI application. This study aimed explore accuracy event-related desynchronization (ERD) tasks. Materials Methods: We recruited 13 stroke 3 traumatic brain injury, perform MA a self-control design. accuracies from bilateral, ipsilesional,...
<title>Abstract</title> Severe asthenozoospermia is a significant cause of male infertility, commonly associated with genetic defects affecting sperm motility. However, the specific contributors remain underexplored. This study aimed to identify variant responsible for severe in two siblings and evaluate clinical validity gene-disease relationship between <italic>SPAG</italic>17 this condition. We performed whole exome sequencing (WES) on diagnosed asthenozoospermia. Sperm motility...
Mirror therapy (MT) is an effective approach in stroke recovery, but its impact on subcortical neural reorganization remains unclear. Thus, we aimed to investigate the neuroplastic effects white matter due MT. In this study, thirty-three participants with were recruited and randomly assigned into MT group (n=16) or control (n=17) for a 4-week intervention. Before after intervention, motor recovery was evaluated using Fugl-Meyer Assessment upper limb subscale (FMA-UL), structure function...
ABSTRACT Genetic diversity is vital for population survival, yet there a paucity of studies focusing on the effectiveness establishing protected areas maintaining genetic threatened plant species. To evaluate in situ conservation measures, we used simple sequence repeats (SSR) and single nucleotide polymorphisms (SNP) markers to monitor temporal dynamics wild rice Oryza rufipogon both unprotected populations China between 2001 2020. Unprotected tended have decreased census sizes ( Nc )...