A5047488677- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Ideological and Political Education
- Urinary Tract Infections Management
- Mycobacterium research and diagnosis
- Nosocomial Infections in ICU
- Pharmaceutical and Antibiotic Environmental Impacts
- Streptococcal Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Innovative Educational Techniques
- Antifungal resistance and susceptibility
- Infant Nutrition and Health
- Enterobacteriaceae and Cronobacter Research
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Neonatal and Maternal Infections
- Educational Reforms and Innovations
- Higher Education and Teaching Methods
- Bacterial biofilms and quorum sensing
- Nanocomposite Films for Food Packaging
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Cannabis and Cannabinoid Research
Ningxia Medical University
2014-2025
Ningxia Medical University General Hospital
2014-2024
Weifang People's Hospital
2024
Children's Hospital of Fudan University
2022
Jilin Vocational College of Industry and Technology
2010-2021
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2015-2018
Wenzhou Medical University
2015-2018
Mudanjiang Medical University
2017
AstraZeneca (Singapore)
2017
Abstract Antimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Surveillance Network (CHINET) was established 2005 to monitor antimicrobial country. This study analyzed CHINET data from teaching hospitals and evaluated trends of AMR 2018 2022. A range 163,636 301,917 isolates obtained per year, majority being Gram-negative bacilli (69.0% 71.8%). The proportion important...
Objective: to investigate the prevalence and antimicrobial resistance of Enterococcus species isolated from a university hospital, explore mechanisms underlying resistance, so as provide clinical evidence for inappropriate use agents control prevention enterococcal infections. Methods: total 1,157 strains various specimens January 2010 December 2012 in General Hospital Ningxia Medical University were identified level with VITEK-2 COMPACT fully automated microbiological system, susceptibility...
Objective: The purpose of this study was to investigate the clinical distribution and genotyping Stenotrophomonas maltophilia, its resistance antimicrobial agents, possible mechanisms drug resistance. Methods: S. maltophilia isolates were collected from specimens in a university hospital Northwestern China during period between 2010 2012, identified species level with fully automated microbiological system. Antimicrobial susceptibility testing performed for Kirby-Bauer disc diffusion method....
This study aimed to assess the resistance phenotype, virulence and genetic characteristics of a blaNDM−1 blaSHV−12 co-harboring ST65 K2 Klebsiella pneumoniae (KP114), which was isolated from General hospital Ningxia Medical University. Antibiotic susceptibility test determined by Vitek 2 Compact system. Multilocus Sequence typing (MLST), antimicrobial genes were examined PCR Sanger sequencing. The KP114 evaluated through string test, macrophage phagocytosis assay, serum mouse infection...
Abstract: Urinary tract infections (UTIs) are common nosocomial infections. This study evaluated the prevalence, pathogens, antibiotic resistances, clinical outcomes, and hospitalization costs associated with complicated UTIs in southern China, risk factors delaying patient discharge. We retrospectively reviewed electronic medical records of 4,284 (61.4% women) UTI-related hospitalizations from 2008 to 2013. Average age was 61.1 years median hospital stay 11 days. Pathogens were isolated...
Complicated skin and soft tissue infections (cSSTI) are some of the most commonly treated in hospitals, place heavy economic burdens on patients society. Here we report findings from an analysis cSSTI based a retrospective study which was conducted within Chinese inpatient population. We focused our research patient population, antibiotic treatment, clinical outcome burden. The population comprised 527 selected hospitalized between 2008 2013. Among hospitalizations with microbiological...
Abstract Antimicrobial resistance poses a significant threat to global public health, especially for Enterobacterales. In this study, we investigated the distribution and antimicrobial of Enterobacterales in children China Surveillance Network (CHINET) 2015–2021. total, 81,681 strains isolated from were collected period, accounting 50.1% Gram-negative organisms. The most frequently Escherichia coli , Klebsiella spp., Salmonella Enterobacter spp. main sources isolates urine respiratory tract,...
To develop an index of the quality nutritional care premature infants based on change in weight Z score from birth to discharge and illustrate use this comparing performance different NICUs.Retrospective data analysis was performed compare growth born three perinatal centers. Infants with gestational age ≤ 32 weeks who survived 2006 2010 were included. Weight scores at calculated by method Fenton. Using one NICU as reference, a multivariable linear regression model developed. Employing...
To evaluate the in vitro antimicrobial activities of tedizolid, linezolid and other comparators against clinically significant Gram-positive cocci isolates from hospital-acquired pneumonia (HAP), skin soft tissue infection (SSTI) bloodstream (BSI), 2140 nonduplicate (23.7 % isolated HAP, 46.8 SSTI 29.5 BSI) were consecutively collected 26 hospitals 17 cities across China during 2014. These pathogens included 632 methicillin-resistant Staphylococcus aureus, 867 methicillin-sensitive 299...
Infections caused by multidrug-resistant (MDR) Enterobacterales , especially carbapenem-resistant (CRE), have been a challenging clinical problem due to the limited therapeutic options. Therefore, need develop novel antimicrobial agents and evaluate their activities against in vitro is urgent.
The emergence of carbapenem-resistant Enterobacteriaceae (CRE) has become a major public health concern worldwide and new challenge in the treatment infectious diseases. molecular characteristics Enterobacter cloacae Ningxia China are unknown. In this study, we reported 10 E. isolates from General Hospital Medical University, largest university hospital between January 2012 December 2013. Bacteria were identified by Vitek2 compact identity non-duplicate was further confirmed PCR sequencing....
Objectives: Ceftazidime–avibactam is a novel synthetic beta-lactam + beta-lactamase inhibitor combination. We evaluated the performance of gradient diffusion strip method and disk for determination ceftazidime–avibactam against Enterobacterales Pseudomonas aeruginosa. Methods: Antimicrobial susceptibility testing 302 clinical aeruginosa isolates from two centers were conducted by broth microdilution (BMD), method, ceftazidime–avibactam. Using BMD as gold standard, essential agreement (EA),...
Purpose: To understand the detection rate and distribution characteristics of Linezolid-nonsusceptible Enterococcus (LNSE) analyze molecular typing main drug resistance mechanisms LNSE, providing a theoretical basis for precision prevention control LNSE hospital infections. Methods: A total 40 strains isolated from clinical specimens between January 1, 2012, December 31, 2022, were collected. The isolates identified by instrument confirmed using microbroth dilution method. WHONET 5.0...
This study aimed to retrospectively investigate the epidemiology and molecular characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates from neonatal intensive care units (NICU) between 2017 2021.
Abstract Objectives The objective of this study was to identify and analyse the distribution characteristics, toxin genotyping antimicrobial susceptibility Clostridium perfringens investigate its resistance mechanisms genetic characteristics. Methods MICs various antibiotics against C. were determined using agar dilution method, genes genotypes detected by PCR. Genetic relationships analysed MLST. WGS conducted on DNB system PacBio platforms. Results Analysis 36 strains revealed that major...
To investigate the molecular mechanism underlying interaction between autophagosomes of alveolar type II epithelial (A549) cells and Klebsiella pneumoniae, an in vitro model K. pneumoniae‑infected A549 was established. Western blot analysis immunofluorescence staining were used to detect distribution microtubule‑associated protein 1A/1B‑light chain 3 (LC3) expression LC3‑phosphatidylethanolamine conjugate (LC3‑II). treated with different concentrations autophagy inhibitor or promoter for...
Background: The etiology, epidemiology, treatment patterns, and clinical outcomes of neonatal pediatric pneumonia patients in China are not well reported. This retrospective chart review study aimed to describe such information among (0 27 days) (28 days <18 years) two regions China. Methods: Electronic medical records hospitalizations (aged admitted between 2008 2013 from four hospitals under Guangdong Provincial Hospital Chinese Medicine (Southern China) 2010 2014 at Peking University...
Background: An increasing number of infections due to methicillin-resistant Staphylococcus aureus ( S. ) have been reported worldwide. To explore the risk factors associated with methicillin-resistance among neonates confirmed and thereby help selection appropriate empirical antibiotics. Methods: We compared a group hospitalized culture (MRSA) methicillin-sensitive (MSSA) based on antimicrobial susceptibility reports. used multivariable regression analysis determine for neonatal MRSA...
Data describing epidemiology, clinical outcomes and treatment patterns, of hospitalised patients with pneumonia in China are limited. We aimed to describe such information among adult southern northern China.We retrospectively reviewed electronic medical records aged ≥18 years, hospitalized between 2008 2013 at Guangdong Provincial Hospital Chinese Medicine (n=3,636), China, 2010 2014 Peking University People's Hospital, Beijing (n=1,689), order collect data on patient demographics,...