A5072184582- Neuropeptides and Animal Physiology
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Tryptophan and brain disorders
- Traditional Chinese Medicine Analysis
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Herpesvirus Infections and Treatments
- Pharmacological Receptor Mechanisms and Effects
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- HIV Research and Treatment
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Chronic Kidney Disease and Diabetes
- melanin and skin pigmentation
- Polysaccharides and Plant Cell Walls
- NF-κB Signaling Pathways
- Ginseng Biological Effects and Applications
- Aquaculture disease management and microbiota
- Medicinal Plants and Bioactive Compounds
- Advanced Glycation End Products research
Xi’an University of Posts and Telecommunications
2024-2025
Changchun University of Chinese Medicine
2015-2024
Zhejiang Center for Disease Control and Prevention
2024
University of Miami
2023-2024
Fudan University
2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Huashan Hospital
2024
Zhejiang Chinese Medical University
2017-2024
Sylvester Comprehensive Cancer Center
2024
First Affiliated Hospital Zhejiang University
2024
Abstract Background and Purpose Membranous nephropathy (MN) is an immune‐mediated glomerular disease in adults. Antibody‐ antigen‐bonding mechanisms have been largely clarified, but the subepithelium immune complex deposition‐mediated downstream molecular are currently unresolved. Increasing evidence has suggested that gut microbiota contribute to MN pathogenesis. Experimental Approach In this study, we identified alterations faecal serum metabolites mediate aryl hydrocarbon receptor (AhR)...
Epidermal growth factor receptor (EGF-R) is an important target in anticancer therapy. Here we report how a novel EGF-R peptide ligand (D4: Leu-Ala-Arg-Leu-Leu-Thr) identified using computer-aided design approach from virtual library of putative binding peptides by screening against the X-ray crystal structure silico and vitro. The selected conjugated with polyethylene glycol (PEG) lipid, lipid moiety peptide-PEG-lipid conjugate inserted into liposome membranes postmodification process. D4...
Abstract Objective: To explore the potential role of endogenous peptide YY (PYY) in long‐term regulation body weight and energy homeostasis. Research Methods Procedures: Fasting postprandial plasma PYY concentrations were measured after an overnight fast 30 to 180 minutes a standardized meal 29 (21 men/8 women) non‐diabetic subjects, 16 whom had follow‐up visit 10.8 ± 1.4 months later. Ratings hunger satiety collected using visual analog scales. Resting metabolic rate (RMR) (15‐hour RMR)...
Oxidative stress is an important factor involved in the progress of heart failure. The current study was performed to investigate whether pinocembrin able ameliorate post-infarct failure (PIHF) and underlying mechanisms.Rats were carried out left anterior descending artery ligation induce myocardial infarction subsequently raised for 6 weeks produce chronic Then administrated every other day 2 weeks. effects evaluated by echocardiography, western blot, Masson's staining, biochemical...
ABSTRACT The increasing use of ceftazidime-avibactam has led to the emergence a wide range ceftazidime-avibactam-resistant bla KPC-2 variants. Particularly, conventional carbapenemase phenotypic assay exhibited high false-negative rate for In this study, three colloidal gold immunoassays, including Gold Mountainriver CGI test, Dynamiker test and NG-Test CARBA5, GeneXpert Carba-R, were used detect presence its various variants in 42 Klebsiella pneumoniae strains. These strains covered (13/42)...
Comparison of ex-vivo soft tissue measurements using the GE/Lunar pencil (DPX-L; Co., Madison, WI) and fan beam (Prodigy dual-energy X-ray absorptiometers (DXA) Co.).Intra-instrument reliability was assessed by repeatedly scanning phantoms for lean (water) fat (methanol) one DPX-L two identical Prodigy DXAs at fast, medium, slow scan modes. For each machine, 10 scans phantom were performed speed. The number per instrument totaled 60. Data analyzed ANOVA to ascertain whether speed affected...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense RNA virus with an unusually large genome of approximately 30 kb. It highly transmissible and exhibits broad tissue tropism. The third most pathogenic all known coronaviruses, severe (SARS-CoV-2), responsible for the clinical manifestation as disease 2019 (COVID-19), which has resulted in loss millions lives on global scale. This pandemic prompted significant efforts to develop therapeutic strategies that target...
Abstract Background MicroRNAs (miRNAs) have been identified as important participants in the development of atherosclerosis (AS). The present study explored role miR-128-3p dysfunction vascular smooth muscle cells (VSMCs) and underlying mechanism. Methods Human VSMCs ApoE knockout (ApoE −/− ) C57BL/6J mice were used to establish AS cell animal models, respectively. Expression levels miR-128-3p, forkhead box O4 (FOXO4) matrix metallopeptidase 9 (MMP9) detected using qRT-PCR Western blot,...
The plant Millettia pulchra was commonly used in folk medicine for the management of inflammation. However, there no scientific rationale these effects and mechanism action remained incompletely understood. present study designed to investigate antiinflammatory analgesic activities an ethanol extract stem M. (EMP) vivo, explore activity compounds isolated from EMP vitro. We found that reduced xylene-induced ear edema relieved both acetic acid-induced pain hot plate test. Additionally, a...
Background: Oxidative stress-induced endothelial cell death, such as apoptosis and autophagy, plays a critical role in ischemia-reperfusion injury. Protocatechualdehyde (PCA) is major bioactive component of the traditional Chinese medicine Salvia miltiorrhiza Bunge (Lamiaceae), it has been proved to be effective prevention treatment ischemic cardiovascular cerebrovascular diseases. However, its oxidative death underlying mechanisms remains unclear. This study aims investigate effects PCA on...
The muscarinic acetylcholine receptor subtype M3 (CHRM3) gene is expressed in islet beta-cells and has a role stimulating insulin secretion; therefore, CHRM3 was analyzed as candidate for type 2 diabetes Pima Indians. Ten variants were genotyped family-based sample (n = 1,037), 1 variant (rs3738435) located the 5' untranslated region of an alternative transcript found to be modestly associated with both early-onset acute response small subset these subjects. To better assess whether this...
4-pentylphenol (PP) and 3-methyl-4-nitrophenol (PNMC), two important components of vehicle emissions, have been shown to confer toxicity in splenocytes. Certain natural products, such as those derived from walnuts, exhibit a range antioxidative, antitumor, anti-inflammatory properties. Here, we investigated the effects walnut polyphenol extract (WPE) on immunotoxicity induced by PP PNMC murine splenic lymphocytes. Treatment with WPE was significantly enhance proliferation splenocytes exposed...
Breast cancer is one of the leading causes deaths in female worldwide. Doxorubicin represents most common chemotherapy for breast cancer, whereas side effects and development resistance impede its effect on chemotherapy. Nicotinamide (NAM), serves as sirtuins' inhibitor, effectively suppressing various types cancer. However, NAM drug are need to be fully investigated.Breast doxorubicin-resistant cells MCF-7/ADR doxorubicin-sensitive MCF-7 were applied this study. Cell proliferation was...