A5018813034- Biological and pharmacological studies of plants
- Traditional Chinese Medicine Analysis
- Immune Response and Inflammation
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Plant tissue culture and regeneration
- Neurological Disease Mechanisms and Treatments
- Phytochemistry and Biological Activities
- Polysaccharides and Plant Cell Walls
- Wound Healing and Treatments
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Angiogenesis and VEGF in Cancer
- Phytoestrogen effects and research
- Metabolomics and Mass Spectrometry Studies
- Fungal Biology and Applications
- Food Quality and Safety Studies
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Chromatography in Natural Products
- Antioxidant Activity and Oxidative Stress
- Flavonoids in Medical Research
- Plant Pathogens and Fungal Diseases
- GABA and Rice Research
Zhejiang Chinese Medical University
2016-2025
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Shaanxi University of Chinese Medicine
2024
Life University
2014
Zhejiang University
2009-2013
Culture Resource
2012
Shenzhen International Travel Health Care Center
2011
Zhejiang University of Technology
2011
Ethanol extract of Bletilla striata has remarkable anti-inflammatory and anti-pulmonary fibrosis activities in the rat silicosis model. However, its active substances molecular mechanism are still unclear. To uncover ingredients potential extract, lipopolysaccharide (LPS)-induced macrophage inflammation model phospho antibody array were used. Coelonin, a dihydrophenanthrene compound was isolated identified. It significantly inhibited LPS-induced interleukin-1β (IL-1β), interleukin-6 (IL-6)...
Four new 9',10'-dihydro-biphenanthrenes, including an unprecedented 1,2'-linked biphenanthrene, 4,7,3',5'-tetramethoxy-9',10'-dihydro(1,2'-biphenanthrene)-2,7'-diol (1), a 1,3'-linked 4,7,7'-trimethoxy-9',10'-dihydro(1,3'-biphenanthrene)-2,2',5'-triol (2), and two 1,1'-linked biphenanthrenes, 4,7,4'-trimethoxy-9',10'-dihydro(1,1'-biphenanthrene)-2,2',7'-triol (3) 4,7,3',5'-tetramethoxy-9',10'-dihydro(1,1'-biphenanthrene)-2,2',7'-triol (4), as well known biphenanthrenes (5, 6), were isolated...
Salvianolic acid C (SAC) is a major bioactive component of Salvia miltiorrhiza Bunge (Danshen), Chinese herb for treating ischemic stroke (IS). However, the mechanism by which SAC affects IS has not yet been evaluated, thus network pharmacology integrated molecular docking strategy was performed to systematically evaluate its pharmacological mechanisms, were further validated in rats with cerebral ischemia. A total 361 potential SAC-related targets predicted SwissTargetPrediction and...
This study was carried out to evaluate the utilization probability of fibrous root part (FRP) Bletilla striata, which usually discarded and harvesting pseudobulb (PSP). The chemical composition, total phenolic content, DPPH radical scavenging activity, Ferric-reducing antioxidant power tyrosinase inhibition activity were compared between FRP PSP. Antioxidant pro-oxidant effect as well antitumor extract PSP analyzed by in vitro cell system well. Thin layer chromatography high performance...
Influenza represents a serious public health concern. The emergence of resistance to anti-influenza drugs underlines the need develop new drugs. This study aimed evaluate viral activity and possible mechanisms 12 phenanthrenes from medicinal plant Bletilla striata (Orchidaceae family).Twelve were isolated identified B. striata. virus A/Sydney/5/97 (H3N2) propagated in embryonated chicken eggs was used. Phenanthrenes mixed with incubated at 37 °C for 1 h then inoculated into 9-day-old via...
Tetrastigma hemsleyanum Diels et Gilg is a traditional Chinese herbal medicine with high medicinal value, and antitumor, antioxidant anti-inflammatory biological activities. However, while several studies have focused on flavonoids in tubers, there are few the enhanced immune effect of polysaccharides (THP). In this study, we evaluated antitumor THP lung tumor model explored mechanism activity through intestinal flora. addition, cyclophosphamide (CTX)-induced immunosuppression was used to...
Tetrastigma Hemsleyanum Diels et Gilg (Sanyeqing, SYQ), a traditional herb native to China, has been widely used in the treatment of inflammatory diseases, febrile convulsions and dysentery. Previous studies have demonstrated hypoglycemic, anti-inflammatory anti-pyretic effects polysaccharides from SYQ (SYQP). However, role SYQP acute lung injury (ALI) remained unknown. Our present study aimed explore protective ALI explained its underlying mechanism. In vivo, Balb/c mice were...
The healing process of a diabetic wound (DW) is often impeded by series interrelated factors, including severe infection, persistent inflammation, and excessive oxidative stress. Therefore, it particularly crucial to develop medical dressing that can address these issues simultaneously. To this end, different ratios Bletilla striata polysaccharide (BSP) berberine (BER) were physically blended with Carbomer 940 (CBM940) composite hydrogel as dressing. BSP/BER was characterized using SEM,...
We have previously shown that ethanol or chloroform extracts of the leaves Impatiens balsamina (LIB) anti-tumor activity against human hepatocellular carcinoma cell line HepG2. The were separated into five fractions according to polarity. An MTT assay indicated two had and petroleum ether fraction (PEF) was most active. But available quantities both PEF (CHF) limited, precluding further study. extract (CHE) shared almost all same spots with CHF plentiful enough carry out separations. Thus,...