Lianhua Wei
A5039751965- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Phenothiazines and Benzothiazines Synthesis and Activities
- Biosensors and Analytical Detection
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- CRISPR and Genetic Engineering
- Antibiotic Use and Resistance
Gansu Provincial Hospital
2024
Gansu University of Traditional Chinese Medicine
2024
Abstract Antimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Surveillance Network (CHINET) was established 2005 to monitor antimicrobial country. This study analyzed CHINET data from teaching hospitals and evaluated trends of AMR 2018 2022. A range 163,636 301,917 isolates obtained per year, majority being Gram-negative bacilli (69.0% 71.8%). The proportion important...
Background Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant clinical challenge due to its multidrug resistance. Diacerein (DIA), primarily used treat degenerative joint diseases, has recently been found exhibit antibacterial activity, though specific mechanisms remain unclear. Methods The minimum inhibitory concentration (MIC) and bactericidal (MBC) of DIA, as well in - vitro combination susceptibility testing, were determined using the broth microdilution method....
To evaluate the in vitro activities of eravacycline, tedizolid, nemonoxacin, norvancomycin, and ceftaroline against Staphylococcus Enterococcus species isolates were collected as part China Antimicrobial Surveillance Network (CHINET) 2019 to provide susceptibility data for spp. their future development application clinical practice. testing was performed using CLSI broth microdilution reference method. Eravacycline highly active isolates, proved by MIC50/90: 0.06/0.125, 0.06/0.25, 0.125/0.5,...
Purpose: Accurate detection and identification of pathogens their associated resistance mechanisms are essential prerequisites for implementing precision medicine in the management Carbapenem-resistant Enterobacterales (CRE). Among various mechanisms, production KPC carbapenemase is most prevalent worldwide. Consequently, this study aims to develop a convenient precise nucleic acid platform specifically blaKPC gene. Methods: The initial phase our research methodology involved developing...