A5100421403- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Lymphoma Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Nutrition and Health in Aging
- Pharmaceutical and Antibiotic Environmental Impacts
- CNS Lymphoma Diagnosis and Treatment
- Frailty in Older Adults
- Pharmacological Effects of Natural Compounds
- Viral-associated cancers and disorders
- Blood groups and transfusion
- Musculoskeletal pain and rehabilitation
- Bacterial Infections and Vaccines
- Bacterial Identification and Susceptibility Testing
- Biosimilars and Bioanalytical Methods
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Respiratory viral infections research
- Treatment of Major Depression
- Inflammatory mediators and NSAID effects
- Health Systems, Economic Evaluations, Quality of Life
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Protein Degradation and Inhibitors
Fudan University
2013-2025
Huashan Hospital
2014-2025
Sanofi (China)
2024-2025
National Health and Family Planning Commission
2019-2025
Northwest Normal University
2014-2024
Yangzhou University
2023-2024
Tsinghua University
2024
West China Hospital of Sichuan University
2024
Peking University Shenzhen Hospital
2024
Sichuan University
2024
Abstract Antimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Surveillance Network (CHINET) was established 2005 to monitor antimicrobial country. This study analyzed CHINET data from teaching hospitals and evaluated trends of AMR 2018 2022. A range 163,636 301,917 isolates obtained per year, majority being Gram-negative bacilli (69.0% 71.8%). The proportion important...
Abstract INTRODUCTION Various associations between social factors and motoric cognitive risk syndrome (MCR) have been reported. However, whether frailty (integrated from multiple factors) is associated with MCR still unclear. METHODS We included 4657 individuals without at Round 1 of the NHATS as discovery sample, 3075 newly recruited 5 independent validation sample. Social was assessed by five items. defined presence both subjective complaints slow gait speed in dementia or mobility...
The purpose of this study was to evaluate the interocular symmetry several biometric parameters between both eyes. right and left eye 397 subjects in 14 parameters, spherical equivalent refractive error (SE), Jackson crossed cylinder power astigmatism with axes at 90° 180° (RJ0) 45° 135° (RJ45), best-corrected visual acuity (BCVA), average corneal curvature (CC), (CJ0 CJ45), asphericity coefficient (Q), intraocular pressure (IOP), central thickness (CCT), axial length (AL), anterior chamber...
Abstract Major depressive disorder (MDD) is the most prevalent form of depression and becoming a great challenge for public health medical practice. Although first-line antidepressants offer therapeutic benefits, about 35% depressed patients are not adequately treated, creating substantial unmet need. A multicenter, double-blind, randomized, placebo-controlled phase 3 clinical trial was conducted in with MDD China to assess efficacy safety ansofaxine (LY03005), potential triple reuptake...
Introduction The establishment of clinical breakpoints for antimicrobial drug is crucial guiding appropriate therapeutic interventions. This study aims to identify the pharmacokinetic/pharmacodynamic (PK/PD) cut-offs using sitafloxacin against target pathogens support breakpoint sensitivity testing. Methods A population PK (PopPK) model was built (342 subjects) calculate dosing-regimen-dependent (50 mg q12 h, 100 q24 h and h) parameters sitafloxacin-infected patients, which were combined...
Social frailty, a multidimensional construct encompassing various social behaviors, resources, and needs, significantly impacts cognitive health in older adults. Despite existing studies linking specific factors to function, the association between frailty long-term trajectories remains underexplored. This study aims evaluate longitudinal trajectory of function dementia-free prospective cohort used data from National Health Aging Trends Study (NHATS). was assessed using Makizako Frailty...
Aims Venglustat is an oral glucosylceramide synthase inhibitor under clinical investigation to treat various lysosomal storage diseases. Metabolism a main pathway for its elimination in humans with CYP3A being the major contributor. This study aims evaluate effect of inhibition (using itraconazole) on venglustat exposure and develop validate physiologically based pharmacokinetic (PBPK) model assess effects additional inhibitors varying potencies pharmacokinetics. Methods An open‐label,...
Objective The aim of this study was to compare the early clinical outcomes all-inside anterior cruciate ligament (ACL) reconstruction using hamstring tendons augmented augmentation and system (LARS) versus alone as a control. Methods This included 99 patients with ACL injuries who underwent arthroscopic either LARS internal brace combined tendon (augmentation group, n = 48) or (hamstring 51). Postoperative follow-up conducted Lysholm, International Knee Documentation Committee (IKDC),...
Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well disease, resulting in changes the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our understanding of disease transition from infection pneumococcus serving model organism. Using conserved surface proteins highly...
Objective: FL058 is a novel beta-lactamase inhibitor with broad spectrum of activity and favorable safety profile. The objective this study was to evaluate pharmacokinetic/pharmacodynamic (PK/PD) relationships for the combination meropenem in an vitro infection model. Methods: By simulating human concentration-time profiles model, combined when administered 1 g/0.5 g, g/1 2 g/2 g q8h by 3-h infusion achieved approximately 2- 4-log10 kill KPC/OXA-producing Klebsiella pneumoniae Escherichia...
A comprehensive design offers global pneumococcal vaccine coverage.
ABSTRACT Purpose It has been hypothesized that the corticospinal tract (CST) is involved in neural origins underlying muscular deficits after an ankle sprain. Microstructural differences CST have reported patients with and without a history of sprain, but causal links between injuries not verified. This study aimed to explore whether genetically predisposed sprains would impair integrity organization neurites, manifesting as reduced fractional anisotropy (FA) increased orientation dispersion...
A novel ZrO<sub>2</sub> nanoparticle coated TiO<sub>2</sub>-based fiber for solid-phase microextraction was fabricated sensitive determination of ultraviolet filters in environmental water samples.
That patients with acute radiculopathy caused by lumbar disc herniation (LDH) will benefit from spinal manipulation (SM) treatment has been taken for granted, despite no solid evidence to support that claim. There is a demand win-win SM both effective and less risky, we attempt use this trial demonstrate such treatment. In study, Feng's Spinal Manipulative Therapy (FSM) selected as the observational SM. FSM can be performed either or mobilization, also easily mimicked sham Two hundred...
A disease-specific, hybrid vector is developed for pneumococcal disease vaccine.
Abstract Background Serum neurofilament light chain (sNfL) has been identified as a biomarker for neurologic diseases. However, sNfL remains unknown to be responsible depression. Aims The aim of this research was explore the relationship between levels and depression in US adults. Methods In cross-sectional survey general population, we investigated representative data involving 10,175 participants from 2013–2014 cycle National Health Nutrition Examination Survey (NHANES). Depression...
Purpose: To investigate the frequency and clinical relevance of missense mutation at position 265 changing leucine to proline in myeloid differentiation factor 88 gene (MYD88 L265P) vitreous Chinese patients with vitreoretinal lymphoma (VRL) using droplet digital polymerase chain reaction (ddPCR).Methods: Vitreous fluid (VF) from 29 eyes 20 VRL North Huashan Hospital were included. MYD88 L265P analysis VF was performed ddPCR. Associations between clinicopathologic characteristics analyzed...
To explore the application effect of clinical basic integration teaching mode constructed by case studies and MOOC platform in obstetrics gynecology internship face public health emergencies.One hundred ten medical students grade 2020 were selected as experimental group, 110 2021 control group. The group adopted online combined with platform, while offline traditional probation method. Comprehensive test questionnaire used to evaluate compare two groups students.The was found be superior...
Desvenlafaxine and duloxetine are selective serotonin norepinephrine reuptake inhibitors. Their efficacy has not been directly compared using statistical hypotheses. This study evaluated the non-inferiority of desvenlafaxine extended-release (XL) to in patients with major depressive disorder (MDD).In this study, 420 adult moderate-to-severe MDD were enrolled randomly assigned (1:1) receive 50 mg (once daily [QD]) XL (n = 212) or 60 QD 208). The primary endpoint was a comparison based on...
Abstract A simple validated high performance liquid chromatography method was developed for the evaluation of effect three kinds active ingredients in traditional Chinese medicine (TCM) on pharmacokinetics glycyrrhetinic acid (GA),a kind component from most commonly used TCM licorice. Our results revealed that all calibration curves displayed good linearity. Intra- and inter-day precision GA ranged 2.54 to 3.98% 4.95 7.08%, respectively. The recovery rates were determined be 96.3–106.4%. All...
Anemia correlates with worse outcomes in patients undergoing percutaneous coronary intervention (PCI), improved anemia can improve the who underwent PCI. But influence of on long-term ischemic events after PCI remains unknown.We analyzed 8,825 consecutive at General Hospital Shenyang Military Region and identified 581 anemia. Patients (anemia vs. no anemia) were compared using a propensity score analysis to best match between groups. The main outcome this study is 3-year PCI, secondary...