A5080629031- Plant Molecular Biology Research
- Ferroelectric and Piezoelectric Materials
- Plant Stress Responses and Tolerance
- Plant Reproductive Biology
- Acoustic Wave Resonator Technologies
- Plant Physiology and Cultivation Studies
- Postharvest Quality and Shelf Life Management
- Plant Gene Expression Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Plant nutrient uptake and metabolism
- Plant tissue culture and regeneration
- Plant responses to water stress
- Theoretical and Computational Physics
- Photosynthetic Processes and Mechanisms
- Material Dynamics and Properties
- Multiferroics and related materials
- Inflammasome and immune disorders
- Seed Germination and Physiology
- CRISPR and Genetic Engineering
- Plant and animal studies
- Solid-state spectroscopy and crystallography
- Genetically Modified Organisms Research
- Plant Surface Properties and Treatments
- Enzyme-mediated dye degradation
Peking University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Zhejiang Chinese Medical University
2025
Yangzhou University
2015-2024
Gansu Agricultural University
2019-2024
Anhui Medical University
2024
Southwest University
2024
China-Japan Friendship Hospital
2022-2024
Wenzhou Medical University
2024
Academy of Military Medical Sciences
2024
The draft genome of the pear ( Pyrus bretschneideri ) using a combination BAC-by-BAC and next-generation sequencing is reported. A 512.0-Mb sequence corresponding to 97.1% estimated size this highly heterozygous species assembled with 194× coverage. High-density genetic maps comprising 2005 SNP markers anchored 75.5% all 17 chromosomes. encodes 42,812 protein-coding genes, these, ∼28.5% encode multiple isoforms. Repetitive sequences 271.9 Mb in length, accounting for 53.1% genome, are...
VPS35, a major component of the retromer complex, is important for endosome-to-Golgi retrieval membrane proteins. Although implicated in Alzheimer’s disease (AD), how VPS35 regulates AD-associated pathology unknown. In this paper, we show that hemizygous deletion Vps35 Tg2576 mouse model AD led to earlier-onset AD-like phenotypes, including cognitive memory deficits, defective long-term potentiation, and impaired postsynaptic glutamatergic neurotransmission young adult age. These deficits...
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been increasingly reported in China. Here, a multicentre, longitudinal surveillance study on CR-hvKP is described.We retrospectively investigated carbapenem-resistant K. (CRKP) 56 centres across China during 2015-17 and screened the virulence genes (iucA, iroN, rmpA rmpA2) for presence of plasmids. Hypermucoviscosity, serum killing Galleria mellonella lethality experiments were conducted to identify among strains with...
Due to the orthorhombic-tetragonal polymorphic phase transition near room temperature, undesirable large temperature dependence of piezoelectric properties is observed over common usage range in BaTiO3 ceramics with high d33 values. Whereas shifting upward by partially substituting Ti Zr effective reducing dependence, serious long-term degradation occurs. However, it found that this could be overcome incorporating a small amount CuO additive. CuO-modified Ba(Ti0.9625Zr0.0375)O3 possess...
Pear (Pyrus pyrifolia L.) has an S-RNase-based gametophytic self-incompatibility (SI) mechanism, and S-RNase also been implicated in the rejection of self-pollen genetically identical pollen. However, RNA degradation might be only beginning SI response, not end. Recent vitro studies suggest that triggers mitochondrial alteration DNA incompatible pollen tube Pyrus pyrifolia, it seems a relationship exists between self S-RNase, actin depolymerization degradation. To further uncover response...
REPRESSOR OF SILENCING 1 (ROS1) is a DNA demethylation enzyme that was previously identified during genetic screen for the silencing of both RD29A-LUC and 35S-NPTII transgenes on T-DNA construct. Here we performed to identify additional mutants in which transgene silenced. We several alleles ros1 following components RNA-directed methylation (RdDM) pathway: NRPD1 (the largest subunit polymerase IV), RDR2, NRPE1 V), NRPD2, AGO4, DMS3. Our results show RdDM pathway due reduced expression ROS1...
Trehalose-6-phosphate synthase (TPS) is significant in the growth, development and stress resistance of plants. We identified cucumber TPS family its physicochemical properties, domains, gene structures, evolutionary relationships, locations, cis -acting elements, conserved motifs, expression patterns using bioinformatics. Our results uncovered seven CsTPS genes genome named CsTPS1–CsTPS7 according to their locations chromosomes. Seven were randomly distributed six Domain analysis showed...
Serine hydroxymethyltransferase (SHMT) is one of the most important enzyme families in one-carbon metabolic pathway and photorespiration within plant cells. Recently studies reported active roles SHMTs defending abiotic stresses. However, genome-scale analysis SHMT tomato currently unknown. In this study, seven genes were identified genome using a genome-wide search approach. addition, their physicochemical properties, protein secondary structure, subcellular localization, gene conserved...
Abscisic acid (ABA) is a plant hormone that plays an important regulatory role in growth and stress response. The AREB (ABA-responsive element binding protein)/ABF (ABRE-binding factor) are ABA-signaling components participate abiotic However, genome-scale analysis of ABF/AREB has not been systemically investigated tomato. This study was conducted to identify tomato family members analyze their response ABA stresses. results show total 10 were identified tomato, which randomly distributed on...
Pear (Pyrus pyrifolia L.) has a S-RNase-based gametophytic self-incompatibility (SI) mechanism, and S-RNase also been implicated in the rejection of self-pollen genetically identical pollen. No studies, however, have examined extent organelle alterations during SI response Pyrus pyrifolia. Consequently, this study focused on to mitochondria nuclear DNA incompatible pollen tubes pear. Methylthiazolyldiphenyl-tetrazolium bromide was used evaluate viability under challenge. The results showed...
VPS35, a major component of the retromer, plays an important role in selective endosome-to-Golgi retrieval membrane proteins. Dysfunction retromer is risk factor for neurodegenerative disorders, but its function developing mouse brain remains poorly understood. Here we provide evidence VPS35 promoting dendritic growth and maturation, axonal protein transport hippocampal neurons. Embryonic CA1 neurons suppressing Vps35 expression by utero electroporation micro RNAs displayed shortened apical...
The T6SS of Pseudomonas aeruginosa plays an essential role in the establishment chronic infections. Inflammatory cytokines mediated by inflammasomes are crucial for body to resist bacterial Here we found that during infection P. , non-canonical inflammasome was activated macrophages, but activation downstream NLRP3 inhibited. VgrG2b is recognized and cleaved caspase-11, generating a free C-terminal fragment. C-terminus can bind NLRP3, inhibiting rejecting NEK7 binding NLRP3. Administrating...