A5100708638- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cerebrovascular and Carotid Artery Diseases
- Prostate Cancer Treatment and Research
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Acute Ischemic Stroke Management
- Mesenchymal stem cell research
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone and Joint Diseases
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Tissue Engineering and Regenerative Medicine
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Protease and Inhibitor Mechanisms
- Folate and B Vitamins Research
- Infectious Aortic and Vascular Conditions
- Cancer Research and Treatments
- Bone and Dental Protein Studies
- Dermatologic Treatments and Research
- Medical Imaging and Analysis
Southern University of Science and Technology
2025
Shandong Provincial QianFoShan Hospital
2020-2025
Shandong First Medical University
2020-2025
Air Force Medical University
2024
Xijing Hospital
2024
Kunming Medical University
2024
Astellas Pharma (China)
2023
Hunan Normal University
2023
Hunan Provincial People's Hospital
2023
Guangdong General Hospital
2015-2021
ABSTRACT The occurrence of inflammation subsequent to haematopoietic stem cell transplantation is associated with an elevated risk transplant‐related mortality (TRM). However, the duration and potential efficacy anti‐inflammatory agents in reducing TRM remain uncertain. We performed a comprehensive investigation examine post‐transplantation alterations inflammatory mediators ascertain correlation between level through neutrophil–lymphocyte ratio, ELISAs cytometric bead array. findings...
This study investigated the efficacy and safety of endovascular revascularization for symptomatic non-acute atherosclerotic intracranial LVO. For large vessel occlusion (LVO), despite aggressive medical treatment, recurrent ischemic stroke or transient attack related to occluded artery still occurs repeatedly. retrospective cohort included patients with LVO who received treatment (EVT), categorized by successful recanalization time interval from symptom onset (＜30 days vs. ≥ 30 days). The...
To determine whether pirfenidone attenuates lung fibrosis by interfering with the hedgehog (Hh) signalling pathway in patients systemic sclerosis-associated interstitial disease (SSc-ILD).Twenty-five SSc-ILD (20 first visit, five who underwent treatment for 6 months) and 10 healthy controls were recruited. Lung tissues obtained open-chest surgery, primary fibroblasts isolated, cultured stimulated pirfenidone. The levels of proteins glioma-associated oncogene 1 (GLI1), suppressor fused...
Conventional stent-based angioplasty was challenged for the high incidence of perioperative complications and follow-up in-stent restenosis (ISR) in treating intracranial atherosclerotic disease (ICAD). Currently, drug-coated balloon (DCB) has shown promise preventing ISR.To compare efficacy safety DCB dilation (with or without stenting) with conventionally only stenting symptomatic ICAD routine clinical practice.From January 2016 to 2019, consecutive patients treated endovascular therapy...
Due to the severe drug resistance situation of Gram-negative bacteria, especially enterobacter, relatively little attention has been paid changes in Gram-positive bacteria species and resistance. Therefore, this study analyzed prevalence a general tertiary-care hospital from 2014 2021, order discover distribution that cannot be easily identified, inform clinicians their respective regions when selecting antimicrobial agents, provide basis for diagnosis bacterial infection, comprehensive...
Background: Although endoscopic plastic biliary stenting is a clinical procedure routinely carried out in patients with common bile duct stones, the effects of on sizes or fragmentation large stones have not been formally established and mechanism this condition controversial. We compared stone after order to develop mechanism. Patients Methods: Endoscopic was performed 45 those difficult extract conventional therapy, including mechanical lithotripsy. The diameter ≥16 mm all patients. Bile...
<h3>Objectives:</h3> High-risk human papillomaviruses (HPVs) are the major causative agents of cervical cancer, and E6 E7 genes encode HPV oncoproteins. The protein high-risk types disturbs cell cycle control down-regulates components antigen presentation pathway, suggesting a role for in tumor immune evasion. We previously reported that HPV-16 expression down-regulation HLA class I was highly correlated lesions. This study aimed to determine whether oncoprotein could down-regulate surface...
Human adipose-derived stromal cells (hASCs) are a promising cell source for bone tissue engineering. However, before the clinical application of hASCs treatment defects, key questions require answers, including whether pre-osteoinduction (OI) and flow cytometric purification indispensible steps in vivo formation by hASCs. In this study, were purified sorting (FCCS). The osteogenic capabilities with or without examined through vitro experiments. We found that pre-OI enhanced capacity 8 weeks...
The rearrangement of the anaplastic lymphoma kinase (ALK) gene accounts for approximately 1%–6% lung adenocarcinoma cases and defines a molecular subgroup tumors characterized by clinical sensitivity to ALK inhibitors such as crizotinib. This study aimed identify relationship between clinicopathologic characteristics non-small cell cancer (NSCLC) analyze therapeutic responses crizotinib conventional chemotherapy in NSCLC patients. A total 487 patients who underwent testing our department...
To investigate the mechanism behind protective effects of gastrodin against microglia-mediated inflammatory responses following hypoxic-ischemic brain damage (HIBD) in neonatal mice.
Background: The aim of the study was to evaluate radiographic features systemic sclerosis-associated interstitial lung disease. Patients and methods: 116 patients with disease (SSc-ILD) from 2010 2019 comprised our retrospective study. All were subject high resolution computed tomography (HRCT). ILD patterns classified into 7 as IIPs analyzed pathology. We chose two staging method semi-quantitative score methods HRCT performance pulmonary function tests. Results: Ground-glass opacities most...
Motivation: Fetal MRI is important in clinical and scientific applications but prone to motion artifacts. Automated image quality assessment (IQA) assists data acquisition subsequent analyses. However, training neural networks for IQA requires labor-intensive manual annotation. Goal(s): To develop a model fetal that doesn't require labels. Approach: A network trained determine the orientation of 2D T2-weighted images. The variation recognition (ORN) inferences central images brain stack used...
Despite the implementation of mechanical thrombectomy, acute ischaemic stroke with large vessel occlusion (AIS-LVO) remains a significant health concern, characterised by substantial morbidity and mortality. Our trial aims to evaluate efficacy safety minocycline in reducing infarct volume improving functional outcomes patients undergoing thrombectomy for anterior circulation AIS-LVO. The MIST-A is prospective, randomised, open-label, blinded-endpoint be conducted across 12 medical centres....
Learning point for cliniciansAccurate diagnosis of culture-negative infective endocarditis with aortic root abscess is difficult but important, as the patients may benefit from early antibiotics and surgical treatment.Multimodality imaging remarkable ring-like appearance should complement echocardiography allow further confirmation in such cases.
Objective To explore the efficacy and safety of endoscopic retrograde cholangiopancreatography (ERCP) in management acute cholangitis during pregnancy. Methods The clinical data 16 pregnant patients with who underwent ERCP and/or sphincterotomy (EST) from August 2001 to February 2009 were retrospectively analyzed. Results Two first trimester, 8 second trimester 6 third had placement a plastic biliary stent trimester. EST was then used remove stones successfully 4 5 months later. performed...