A5101786256- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Anesthesia and Sedative Agents
- Inflammasome and immune disorders
- Advanced biosensing and bioanalysis techniques
- Musculoskeletal pain and rehabilitation
- S100 Proteins and Annexins
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Sarcoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Anesthesia and Pain Management
- Soft tissue tumor case studies
- Transplantation: Methods and Outcomes
- Airway Management and Intubation Techniques
- Spine and Intervertebral Disc Pathology
- Herpesvirus Infections and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Liver physiology and pathology
- Obstructive Sleep Apnea Research
- Autophagy in Disease and Therapy
- Peripheral Nerve Disorders
Shanghai East Hospital
2020-2025
Nankai University
2024-2025
Shanghai First People's Hospital
2023
Dalian Medical University
2022
Chongqing Medical University
2022
Second Affiliated Hospital of Chongqing Medical University
2022
Institut Mines-Télécom Business School
2021
Pain Management Institute
2021
Shanghai Jiao Tong University
2012-2018
National Natural Science Foundation of China
2015
Abstract Objective To determine whether high flow nasal cannula (HFNC) oxygenation can reduce the incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity. Design Multicentre, randomised, parallel group trial. Setting Three tertiary hospitals Shanghai, China. Participants 1000 adult obesity (body mass index ≥28) who were scheduled for endoscopy. Interventions randomly allocated to receive regular or HFNC a procedure propofol and low dose sufentanil. Main...
Pulmonary fibrosis is characterized by lung fibroblast proliferation and collagen secretion. In lipopolysaccharide (LPS)-induced acute injury (ALI), aberrant of fibroblasts initiated in early disease stages, but the underlying mechanism remains unknown. this study, we knocked down Toll-like receptor 4 (TLR4) expression cultured mouse using TLR4-siRNA-lentivirus order to investigate effects LPS challenge on proliferation, phosphoinositide3-kinase (PI3K)-Akt pathway activation, phosphatase...
Background Acute lung injury (ALI) is considered to be the major cause of respiratory failure in critically ill patients. Clinical studies have found that patients with sepsis and after hemorrhage, elevated level high mobility group box-1(HMGB-1) their circulation highly associated ALI, but underlying mechanism remains unclear. Extracellular HMGB-1 has cytokine-like properties can bind Toll-like Receptor-4 (TLR4), which was reported play an important role pathogenesis ALI. The aim this study...
Abnormal and uncontrolled proliferation of lung fibroblasts may contribute to pulmonary fibrosis. Lipopolysaccharide (LPS) can induce fibroblast differentiation through activation phosphoinositide3-Kinase (PI3-K) pathway. However, the detail mechanism by which LPS contributes development fibrosis is not clearly understood. To investigate role phosphatase tensin homolog (PTEN), a PI3-K pathway suppressor, on LPS-induced proliferation, differentiation, collagen secretion PI3-K, we transfected...
Type II alveolar epithelial cell (AECII) apoptosis is one of the most vital causes sepsis-induced acute respiratory distress syndrome (ARDS). Recent evidence has proved that bone mesenchymal stem cell-derived exosomes (BMSC-exos) can effectively reduce ARDS. However, function and molecular mechanism BMSC-exos in AECII remain to be elucidated. In present study, a more significant number apoptosis, high mitochondrial fission p-Drp1 protein levels, low levels biogenesis-related PGC1α, Tfam,...
In Brief Background Hepatic injury induced by ischemia-reperfusion (I/R) after transplantation or lobectomy is a major clinical problem. The potential benefit of remifentanil in these hepatic surgeries remains unknown. current study investigated whether protects the liver against I/R rat model and underlying mechanism involves modulation interleukin (IL)-18 signaling. Methods Male Sprague-Dawley rats were subjected to 45 minutes partial ischemia followed 6 hours reperfusion. Then, they...
Objective: Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. Intravenous (IV) lidocaine during surgery can reduce demand propofol and incidence cardiopulmonary complications. We examined whether IV reduces dose occurrence adverse events gastroscopy patients. Methods: conducted a prospective, single-center, double-blind randomized controlled trial aged ≥ 65 years with ASA I-II. Subjects were...
Postherpetic neuralgia (PHN) is the most common complication of herpes zoster. Methylene blue (MB) an inhibitor nitric oxide synthesis with potentially analgesic and anti-inflammatory properties. Studies have demonstrated that thoracic paravertebral single MB injection effective in treating chronic pain. However, there are rare reports efficacy continuous infusion for pain management PHN patients. The purpose this study was to evaluate therapeutic effects on PHN. A total 104 patients were...
Abstract Lipopolysaccharide ( LPS )‐induced pulmonary fibrosis is characterized by aberrant proliferation and activation of lung fibroblasts. Epigenetic regulation thymocyte differentiation antigen 1 (Thy‐1) associated with fibroblast phenotype transformation that results in cell proliferation. However, it not clear whether the epigenetic Thy‐1 expression required for ‐induced To address this issue better understand relative underlying mechanisms, we used mouse fibroblasts as model to...
During cardiopulmonary bypass (CPB), pulmonary ischemia/reperfusion (I/R) injury can cause acute lung (ALI). Our previous research confirmed that abnormal high-mobility group box 1 (HMGB1) release after CPB was closely related to ALI. However, the mechanism underlying HMGB1-mediated induction of ALI is unclear. study found HMGB1 binds Toll-like receptor 4 (TLR4), leading injury, but direct evidence a role for these proteins in CPB-induced has not been shown. We examined effects inhibiting or...
In Brief BACKGROUND: A number of studies have shown that hydroxyethyl starch (HES) solutions are able to down-regulate the expression inflammatory mediators and inhibit neutrophil-mediated tissue injuries when they used in patients with sepsis or other diseases severe responses. However, our knowledge about underlying mechanisms is limited. Toll-like receptor 4 (TLR4) signaling has a pivotal role processes. this study, we examined possible involvement TLR4 antiinflammatory effects HES....
Remimazolam is a new type of ultra-short-effect intravenous anesthetic, that may provide adequate sedation for endoscopy while causing less cardiovascular or respiratory disturbance than propofol. The aim this clinical study was to compare the efficacy and safety two different doses remimazolam with propofol during colonoscopy.
Anti-cancer effects of curcumol on various cancers have been reported previously. This study focused investigating the role in pancreatic cancer from molecular perspective. The survival patients with high or low expression miR-21-5pand target gene miR-21-5pwere analyzed by bioinformatics. MiR-21-5p tissues was RT-qPCR. Anxenograft-tumor BALB/c nude mice model established and cells were cultured. Later, further treated curcumol. tumor size weightas well as body weight recorded. viability,...
ABSTRACT Our previous study confirmed that cardiopulmonary bypass (CPB) leads to acute lung injury (ALI) via inducing high-mobility group box 1 (HMGB1) release. Recent research showed HMGB1 promotes pulmonary mainly exosomes transport. Currently, alveolar epithelial cell (AEC) necroptosis has been demonstrated be involved in ALI. However, it is unknown whether exosomal inflammatory cytokine ALI by AEC necroptosis, and its underlying mechanisms remain elusive. Here, a prospective cohort was...
Aims of This Study: A randomized clinical trial was undertaken to investigate the efficacy acupoint catgut embedding (ACE) as adjunctive therapy tauroursodeoxycholic acid (TUDCA) on gallbladder emptying and symptoms in patients with gallstone disease. Materials Methods: Between August 2018 January 2019, 70 gallstones our hospital were enrolled this prospective trial. All randomly divided into ACE group (ACE+TUDCA treatment for 8 wk) Sham (Sham ACE+TUDCA wk). In group, all nightly given every...
Solitary fibrous tumor of the pleura (SFTP) is a rare thoracic and usually asymptomatic. Massive SFTP may affect adjacent organs tissues including pulmonary vasculature, bronchus heart. A thoracotomy for massive necessary in severe case. Therefore, it important anesthesiologists to understand condition patients with develop an appropriate anesthetic management strategy. 76-year-old woman presented our clinical center was evaluated as requiring thoracotomy. She received multidisciplinary...