A5101977757- Microbial Inactivation Methods
- Cancer-related molecular mechanisms research
- Viral Infectious Diseases and Gene Expression in Insects
- MicroRNA in disease regulation
- Cellular transport and secretion
- Circular RNAs in diseases
- Tissue Engineering and Regenerative Medicine
- Conducting polymers and applications
- Anesthesia and Neurotoxicity Research
- RNA modifications and cancer
- Immune cells in cancer
- Endoplasmic Reticulum Stress and Disease
- Intensive Care Unit Cognitive Disorders
- Protein purification and stability
- ATP Synthase and ATPases Research
- Circadian rhythm and melatonin
- Congenital heart defects research
- Viral gastroenteritis research and epidemiology
- Anesthesia and Sedative Agents
- Catalytic C–H Functionalization Methods
- Lysosomal Storage Disorders Research
- Organoboron and organosilicon chemistry
- Hydrogels: synthesis, properties, applications
- Advanced Glycation End Products research
- Biofuel production and bioconversion
Tianjin University
2023-2024
Guangdong University of Technology
2024
Shanghai East Hospital
2013-2023
Shanghai First People's Hospital
2023
Bengbu Medical College
2020-2022
ShanghaiTech University
2016-2020
University of Chinese Academy of Sciences
2020
Center for Excellence in Molecular Cell Science
2020
Chinese Academy of Sciences
2020
First Affiliated Hospital of Bengbu Medical College
2020
Emerging evidence suggested that circular RNAs (circRNAs) play critical roles in cervical cancer (CC) progression. However, the and molecular mechanisms of hsa_circ_0007364 tumorigenesis CC remain unclear. In present study, we used bioinformatics analysis a series experimental to characterize novel circRNA, was up-regulated associated with advanced clinical features patients. Hsa_circ_0007364 inhibition notably suppressed proliferation invasion abilities cells vitro reduced tumor growth...
Type II alveolar epithelial cell (AECII) apoptosis is one of the most vital causes sepsis-induced acute respiratory distress syndrome (ARDS). Recent evidence has proved that bone mesenchymal stem cell-derived exosomes (BMSC-exos) can effectively reduce ARDS. However, function and molecular mechanism BMSC-exos in AECII remain to be elucidated. In present study, a more significant number apoptosis, high mitochondrial fission p-Drp1 protein levels, low levels biogenesis-related PGC1α, Tfam,...
Dendrite morphogenesis is essential for a neuron to establish its receptive field and is, thus, the anatomical basis proper functioning of nervous system. The molecular mechanisms governing dendrite branching are not fully understood. Using multi-dendritic PVD in nematode Caenorhabditis elegans, we identify CATP-8/P5A ATPase as key regulator that controls translocation DMA-1 receptor endoplasmic reticulum (ER). specific signal peptide activity CATP-8 this process. Our results reveal P5A may...
Sevoflurane is the most widely used inhaled anesthetic. Environmental enrichment (EE) can reverse sevoflurane-induced learning and memory impairment in young mice. However, mechanism by which EE elicits this effect unclear. The peroxisome proliferator-activated receptor (PPAR) regulatory pathway plays a critical role regulation of inflammation central nervous system diseases. In study, we investigated whether attenuates disability via PPAR signaling pathway. Six-day-old mice were treated...
A rapid and sensitive high-performance liquid chromatographic (HPLC) method was developed for the simultaneous separation determination of chlorogenic acid, caffeic alantolactone isoalantolactone in Inula helenium. The HPLC performed on an Elite Hypersil C18 column (200 × 4.6 mm i.d., 5 µm particle size) with a gradient elution solvent (acetonitrile) B (0.1% phosphoric acid water) at flow rate 1.0 mL/min. Detection monitored 225 nm. recovery ranged from 95.6 to 107.7%, 95.4 104.2%, 95.8...
Atlastin (ATL) is a class of dynamin-like GTPases shaping endoplasmic reticulum (ER) by mediating homotypic membrane fusion. Defect ATLs leads to abnormal ER structure and hereditary spastic paraplegia (HSP), neurodegenerative disease with progressive spasticity. How are regulated maintain the dynamics not clear. Here, we found that SYVN1, an E3 ubiquitin ligase on membrane, regulates shape COPII exporting ubiquitination ATLs, especially ATL1. ATL1 ubiquitinated SYVN1 strongly K285 mildly...
A nickel-catalyzed C–N cross-coupling of organoboronic acids and isoxazoles has been established for the efficient synthesis ( Z ) N -aryl β-enamino esters.
ABSTRACT Our previous study confirmed that cardiopulmonary bypass (CPB) leads to acute lung injury (ALI) via inducing high-mobility group box 1 (HMGB1) release. Recent research showed HMGB1 promotes pulmonary mainly exosomes transport. Currently, alveolar epithelial cell (AEC) necroptosis has been demonstrated be involved in ALI. However, it is unknown whether exosomal inflammatory cytokine ALI by AEC necroptosis, and its underlying mechanisms remain elusive. Here, a prospective cohort was...
Vaccination is a safe and effective approach to prevent deadly diseases. To increase vaccine production, we propose that mechanical stimulation can enhance protein production. In order prove this hypothesis, Sf9 insect cells were used evaluate the in expression of fusion from hepatitis B virus (HBV S1/S2). We discovered ultrasound at frequency 1.5 MHz, intensity 60 mW/cm2, for duration 10 minutes per day increased HBV S1/S2 by 27%. further derived model transport through cell membrane under...
We aim to investigate the changes of The gamma-aminobutyric acid (GABA) signals in adjacent intact dorsal root ganglion (DRG) and contribution these development maintenance neuropathic pain (NPP). After establishment model with lumbar 5 spinal nerve ligation (L5 SNL), GABA-evoked currents were recorded acutely dissociated L4 DRG neurons using whole-cell patch clamp. Moreover, Muscimol or Bicuculline respectively topically injected at time injury post-operative days (POD5). thresholds hind...
Natural polymer-based hydrogels have been wildly used in electronic skin, health monitoring and human motion sensing. However, the construction of with excellent mechanical strength electrical conductivity totally using natural polymers still faces many challenges. In this paper, gelatin oxidized sodium carboxymethylcellulose were to synthesize a double-network hydrogel through dynamic Schiff base bond. Then, was further enhanced by immersion ammonium sulfate solution based on Hofmeister...
Abstract Background NLRP3 inflammasome-mediated alveolar macrophage pyroptosis has been reported in promoting sepsis-related acute respiratory distress syndrome(ARDS).The nuclear factor E2-related (Nrf2) is involved regulating inflammasome activation and pyroptosis. CDDO-imidazole (CDDO-Im), a forceful Nrf2 activator, ARDS lacking its underling mechanism are still unclear. In this study, we aim to investigate the effect of CDDO-Im on lung protection explored underlying molecular mechanisms....