A5101666170- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Acupuncture Treatment Research Studies
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Air Quality and Health Impacts
- DNA Repair Mechanisms
- Genetics and Neurodevelopmental Disorders
- Acute Lymphoblastic Leukemia research
- Virus-based gene therapy research
- Traditional Chinese Medicine Studies
- Autoimmune Bullous Skin Diseases
- Inhalation and Respiratory Drug Delivery
- Bone health and treatments
- Selenium in Biological Systems
- Cancer-related gene regulation
- CAR-T cell therapy research
- Birth, Development, and Health
- Chronic Kidney Disease and Diabetes
- Immunodeficiency and Autoimmune Disorders
- Genetic and rare skin diseases.
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Pregnancy and preeclampsia studies
- Celiac Disease Research and Management
Soochow University
2014-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Institute of Hematology & Blood Diseases Hospital
2025
Harbin Medical University
2018-2024
Kunming University of Science and Technology
2021-2024
Beijing University of Chinese Medicine
2024
Changchun University of Chinese Medicine
2024
University of Pennsylvania
2019-2021
First Affiliated Hospital of Harbin Medical University
2019-2021
Cancer Research Institute
2019-2021
We investigated the in vivo effect of coinfection Mycobacterium tuberculosis on human immunodeficiency virus type 1 (HIV-1) replication using bronchoalveolar lavage (BAL) 11 HIV-1-infected patients with pulmonary and 10 no lung disease. Lung segments involved had significantly elevated HIV-1 branched DNA (bDNA) levels p24 BAL compared uninvolved or from The viral burden was higher than plasma patients, indicating local production virus. bDNA declined over course treatment for three who...
Abstract Beclin 1 is a well-established core mammalian autophagy protein that embryonically indispensable and has been presumed to suppress oncogenesis via an autophagy-mediated mechanism. Here, we show prenatal primary cytoplasmic but rapidly relocated into the nucleus during postnatal development in mice. Surprisingly, deletion of beclin vitro human cells did not block response, attenuated expression several DNA double-strand break (DSB) repair proteins formation complexes, reduced ability...
Abstract Autophagy is essentially a metabolic process, but its in vivo role nuclear radioprotection remains unexplored. We observed that ex autophagy activation reversed the proliferation inhibition, apoptosis and DNA damage irradiated hematopoietic cells. In improved bone marrow cellularity following radiation exposure. contrast, defective conditional mouse model worsened injury, reactive oxygen species (ROS) accumulation caused by Strikingly, an absence or reduction regulatory proteins...
Railways are crucial in economic development and improving people’s livelihoods. Therefore, defect detection maintenance of rails particularly important. In order to accurately separate identify the rail from mixed signals by acoustic emission (AE) techniques, this paper proposes a novel time–frequency separation neural network (TFSNN) architecture solve problems existing blind source (BSS), such as non-stationary low stability convergence. Combined with smoothed pseudo Wigner–Ville...
Autophagy is required for hematopoietic stem cell multilineage differentiation, but the underlying mechanism unknown. Using a conditional mouse model and human leukemia cells, we uncovered mechanistic link between autophagy differentiation. Loss of in cells diminished bone marrow generation functional blood particular lymphocytes, resulted leukemic phenotype elevated Notch signaling. Physiological activity mice was inversely correlated with signaling during adult while pathologically low...
Autophagy protects hematopoietic cells from radiation damage in part by promoting DNA repair. However, the molecular mechanisms which autophagy regulates repair remain largely elusive. Here, we report that this radioprotective effect of depends on STAT3 signaling murine bone marrow mononuclear (BM-MNCs). Specifically, found activation and nuclear translocation BM-MNCs were increased with an mTOR inhibitor decreased knockout gene Atg7. The autophagic regulation is likely mediated induction...
Sirtuin protein family member 3 (Sirt3) has been suggested as a positive regulator in alleviating oxidative stress by acting on the mitochondrial antioxidant machinery solid tumors; however, its role and regulation hematological malignancies poorly understood. Here, we show that contrary to what reported tumors, K562 leukemia cells elevated Sirt3 was associated with stress, depletion of decreased reactive oxygen species (ROS) generation lipid oxidation, but increased ratio reduced...
B-cell acute lymphoblastic leukemia (B-ALL) accounts for the most cancer incidences in children. We present here that autophagy is downregulated pediatric B-ALL, suggesting a possible link between failure and B-ALL leukemogenesis. With t(1;19) xenograft mouse model, we show activation of by preventive administration rapamycin improved survival animals partial restoration hematopoietic stem/progenitor cells, whereas treatment with caused bone marrow cell-cycle arrest. Activation vitro or vivo...
Although plumbagin, a natural naphthoquinone, has exhibited antiproliferative activity in numerous types of cancer, its anticancer potential esophageal squamous cell carcinoma (ESCC) remains unclear. In the present study, effect plumbagin on growth ESCC cells was investigated vitro and vivo. were treated with tested for cycle distribution apoptosis. The involvement STAT3 signaling examined. results demonstrated that treatment suppressed viability proliferation, yet normal epithelial not...
Article6 April 2021Open Access Source DataTransparent process Menin-regulated Pbk controls high fat diet-induced compensatory beta cell proliferation Jian Ma orcid.org/0000-0001-8223-8327 Department of Cancer Biology, Abramson Family Research Institute, University Pennsylvania Perelman School Medicine, Philadelphia, PA, USA Institute for Diabetes, Obesity, and Metabolism, Search more papers by this author Bowen Xing Yan Cao Xin He orcid.org/0000-0002-2131-2092 Kate E Bennett Division...
Osteoarthritis (OA) is a considerable health problem worldwide, and the prevalence of OA varies in different regions. In this study, Kashin-Beck disease (KBD) non-KBD endemic areas was examined, respectively. According to monitoring data, 4 types regions (including none, mild, moderate high KBD areas) Heilongjiang Jilin provinces were selected. All local residents eligible for inclusion criteria have undergone X-ray images hands anteroposterior image knees. A total 1673 cases collected, 1446...
The kidneys are important organs that susceptible to aging. Hyperhomocysteinemia (HHcy) is a risk factor for nephropathy and associated with chronic nephritis, purpuric nephrotic syndrome. Numerous studies have shown elevated serum homocysteine levels can damage the kidneys; however, underlying mechanism of HHcy on kidney remains unclear. In this study, we make use diet-induced rat model in vitro cell culture explore role autophagy HHcy-induced renal aging further explored mechanism. We...