A5062592774- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Folate and B Vitamins Research
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Dermatology and Skin Diseases
- Diet and metabolism studies
- Vitamin D Research Studies
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Eosinophilic Esophagitis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Telomeres, Telomerase, and Senescence
- Gastroesophageal reflux and treatments
- Infant Nutrition and Health
- Bone health and treatments
- Lipid metabolism and disorders
- Neonatal Respiratory Health Research
- Dietary Effects on Health
- Ectopic Pregnancy Diagnosis and Management
- Health and Lifestyle Studies
- Thyroid Cancer Diagnosis and Treatment
- Bone health and osteoporosis research
- Cardiovascular Health and Disease Prevention
Shanghai Municipal Center For Disease Control Prevention
2022-2024
China Astronaut Research and Training Center
2024
Karolinska Institutet
2024
Children's Hospital of Fudan University
2018-2023
Institute of Geographic Sciences and Natural Resources Research
2023
Chinese Academy of Sciences
2023
Nanjing Drum Tower Hospital
2018-2023
University of Chinese Academy of Sciences
2023
Chinese Center For Disease Control and Prevention
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Here, we show that the anaplastic thyroid carcinoma (ATC) features up-regulation of a set genes involved in control cell cycle progression and chromosome segregation. This phenotype differentiates ATC from normal tissue well-differentiated papillary carcinoma. Transcriptional promoters up-regulated are characterized by modular organization featuring binding sites for E2F NF-Y transcription factors cycle-dependent element (CDE)/cell gene homology region (CHR) cis-regulatory elements. Two...
OBJECTIVE To investigate the association of folate and vitamin B12 in early pregnancy with gestational diabetes mellitus (GDM) risk. RESEARCH DESIGN AND METHODS The data this study were from a subcohort within Shanghai Preconception Cohort Study. We included pregnancies red blood cell (RBC) measurements at recruitment (between 9 13 weeks) those three samples available for glucose under an oral tolerance test. GDM was diagnosed between 24 28 weeks’ gestation. Odds ratio (OR) 95% CI having...
Background/Aims: Ubiquitin E3 ligase MARCH7 plays an important role in T cell proliferation and neuronal development. But its ovarian cancer remains unclear. This study aimed to investigate the of cancer. Methods: Real-time PCR, immunohistochemistry western blotting analysis were performed determine expression MARCH7, MALAT1 ATG7 lines clinical specimens. The maintaining malignant phenotype was examined by Wound healing assay, Matrigel invasion assays Mouse orthotopic xenograft model....
Abstract Background Offspring of pregnancy complicated with preeclampsia are at high risk for hypertension, stroke and possibly obesity. The mechanisms behind the association intrauterine exposure to health problems in later life remain largely unknown. aims current investigation were determine changes DNA methylation IGF2 GNAS DMR offspring preeclamptic explore possible underlying between maternal their offspring. Results Umbilical cord blood was taken from infants born women (n=56),...
Offspring of pregnancy complicated with gestational diabetes (GDM) are at high risk for metabolic diseases. The mechanisms behind the association intrauterine exposure to GDM and health problems in later life remain largely unknown. aim this study was clarify alteration methylation levels differentially methylated regions (DMRs) GNAS IGF2 fetuses women explore possible linking maternal diseases offspring.Lymphocytes were isolated from umbilical cord blood infants born 87 81 normal pregnancy....
Integrins that contain an integrin αV subunit contribute to multiple functions promote cancer progression. The goal of this study was determine whether abituzumab (DI17E6, EMD 525797), a humanized monoclonal antibody (mAb) against impacts, prostate To evaluate this, cells were treated with DI17E6 and its effects on proliferation, apoptosis, cell-cycle, adhesion, detachment, migration, invasion phosphorylation downstream targets, including FAK, Akt, ERK, determined. promoted detachment...
Pulsed electromagnetic field (PEMF) has been suggested as a promising method alternative to drug‐based therapies for treating osteoporosis (OP), but the role of PEMF in GIOP animal models still remains unknown. This study was performed investigate effect on bone formation and lipid metabolism further explored several important components targets canonical Wnt signaling pathway rats. After 12 weeks intervention, mineral density (BMD) level whole body increased significantly, serum levels...
Due to the decreasing eradication rate of Helicobacter pylori, some novel alternatives have been developed, such as bismuth-containing quadruple therapy and non-bismuth-containing (sequential concomitant treatment). Little is known about whether a success above 90% can be achieved with these regimens in Chinese children.In this prospective, open, comparative cross-sectional study, we recruited treatment-naïve children (aged between 6 18 years) H pylori infection. The patients were assigned...
We evaluated how effectively the waist-to-height ratio (WHtR) identified cardiometabolic risk (CMR) in children and adolescents, compared with tri-ponderal mass index, percentage of body fat other obesity indexes.
Objectives To demonstrate the accuracy and flexibility of using waist-to-height ratio (WHtR) as a screening tool for identifying children adolescents with cardiometabolic risk (CMR) across wide range prevalence levels among general paediatric populations. Design A nationwide population-based cross-sectional study all data collected at school settings in six cities China. Participants total 8130 aged 7–18 years complete anthropometric CMR measurements based on blood tests were recruited....
Background: Periconception folic acid supplementation has been suggested to protect against congenital heart disease (CHD), but the association between maternal red blood cell (RBC) folate, gold-standard biomarker of folate exposure, and subsequent offspring CHD risk is lacking. Objective: To quantify periconception RBC risk. Design: Prospective, nested, case–control study 1-sample Mendelian randomization. (ClinicalTrials.gov: NCT02737644) Setting: 29 maternity institutions in 12 districts...
Abstract Objective The aim of this study was to investigate the effectiveness an intermittent low‐carbohydrate diet (ILCD) versus calorie restriction (ICR) in young populations and potential mechanisms. Methods Thirty‐four participants aged 9 30 years with cardiometabolic risk were randomized receive a self‐administered 2‐week ILCD (carbohydrate intake ≤ 50 g/d on seven nonconsecutive days) or ICR (500–600 kcal/d for two consecutive days per week). Differences changes obesity measures,...
Recent studies have shown that gene expression profiles change in the livers of animals treated acutely with toxic chemicals such as carbon tetrachloride (CCl(4)). This study was undertaken to evaluate changes mouse liver immediately after a long-term treatment CCl(4) and possible effects cessation on these changes. Adult 129/Sv(pc)J mice were twice week at 1 ml/kg olive oil for 4 weeks. Hepatic pathological observed CCl(4)-treated included necrosis, inflammation, fibrosis, along increased...
AIM:To investigate the effects of four different ingredients zedoary (Curcuma aromatica oil, Curcumol, β-elemence, and Curcumin) on gene expressions hepatic stellate cells (HSCs), to explore molecular mechanism against fibrosis at network level. METHODS:We detected mRNA sequences 50 liver fibrosis-related genes in GenBank designed oligonucleotide probes.We synthesized oligonucleotides with PE8909 DNA synthesizing instrument, carried out microarray OGR-04 dropping instrument aldehyded glass...
Early postanal growth of preterm infants has many effects on early and late health. However, evidence pattern in Chinese infant population during life is insufficient. This study aims to describe the trajectory, catch-up growth, risk overweight first 2 years a community population. All (n = 10,624) received routine childcare one primary maternal child healthcare network 8 were included. Body weight length/height at corrected age (CA) 40 weeks, CA 3 months, 6 9 12 18 24 months extracted...
To evaluate whether the associations of maternal liver dysfunction and function biomarkers (LFBs) with gestational diabetes mellitus (GDM) are independent overweight.Prospective cohort study.A sub-cohort pregnant women seven LFBs examined at 9-13 weeks gestation complete GDM evaluation mid-gestation were extracted from prospective Shanghai Preconception Cohort Study. Associations dysfunction, defined as having any elevated LFB levels, individual levels incidence assessed by adjusting body...
Heterotopic interstitial pregnancy is a rare variant of heterotopic pregnancies, and it poses challenges in treating the preserving intrauterine pregnancy. However, there no clear consensus regarding optimal management. The aim this study was to investigate outcomes women diagnosed with pregnancy.A total 17 between July 2010 December 2015 were included. General characteristics each patient, including age, gravidity parity, history pelvic inflammatory disease or surgery, especially...
Abstract Objective To provide the latest evidence of performance and robustness waist-to-height ratio (WHtR) in discriminating clusters cardiometabolic risk factors (CMRs) promote WHtR routine primary health care practice children, a meta-analysis was used. Methods Searches performed eight databases from inception to July 03, 2020. Inclusion criteria were: (1) observational study, (2) children adolescents, (3) provided measurements, (4) had CMRs as outcomes, (5) diagnostic studies. Exclusion...
To explore changes in telomere length (TL) and mitochondrial copy number (mtDNA-CN) preeclampsia (PE) to evaluate the combined effect of maternal TL mtDNA-CN on PE risk. A case-control study 471 subjects (130 cases 341 age frequency matched controls with gestational rank from 24 42 weeks) was conducted Nanjing Drum Tower Hospital, Jiangsu Province China. Relative (RTL) were measured using quantitative polymerase chain reaction (qPCR), risk compared between groups by logistic regression...
Gestational hypertension (GH) and preeclampsia (PE) are severe adverse gestational complications. Previous studies supported potential link between elevated liver enzyme levels GH PE. However, given the transient physiological reduction of in pregnancy, little is known whether associations high-normal early pregnancy with PE exist pregnant women. Pregnant women this study came from a sub-cohort Shanghai Preconception Cohort, who were four examined at 9-13 weeks without established diseases,...