A5100370511- Pediatric Hepatobiliary Diseases and Treatments
- Mosquito-borne diseases and control
- Intestinal Malrotation and Obstruction Disorders
- Pancreatitis Pathology and Treatment
- Neuroblastoma Research and Treatments
- Malaria Research and Control
- Reproductive Biology and Fertility
- Pancreatic and Hepatic Oncology Research
- Acute Lymphoblastic Leukemia research
- Sepsis Diagnosis and Treatment
- Viral Infections and Vectors
- Gallbladder and Bile Duct Disorders
- Protein Degradation and Inhibitors
- Acute Kidney Injury Research
- Hemodynamic Monitoring and Therapy
- Cancer, Lipids, and Metabolism
- Gastrointestinal disorders and treatments
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Vector-borne infectious diseases
- Ovarian function and disorders
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Neonatal Health and Biochemistry
- Estrogen and related hormone effects
Soochow University
2015-2024
Henan University
2024
Zhejiang Institute of Special Equipment Inspection
2024
Zhejiang University
2022-2024
First Affiliated Hospital of Xinjiang Medical University
2022-2023
Xinjiang Medical University
2022-2023
Sun Yat-sen Memorial Hospital
2013-2023
Sun Yat-sen University
2013-2023
Shanghai Jiao Tong University
2016-2022
Nanfang Hospital
2022
Nanotechnology-mediated anti-inflammatory therapy is emerging as a novel strategy for the treatment of inflammation-induced injury.
Abstract Background Hyperlactatemia upon admission is a documented risk factor for mortality in critically ill adult patients. However, the predictive significance of single lactate measurement at general population children remains uncertain. This study evaluated value blood levels and determined cut-off values predicting in-hospital pediatric population. Methods We enrolled 1109 who were admitted to intensive care unit between July 2008 December 2010. Arterial samples collected first 2...
To evaluate whether early and acquired daily fluid overload (FO), as well fluctuations in accumulation, were associated with adverse outcomes critically ill children severe sepsis.This study enrolled 202 a pediatric intensive care unit (PICU) sepsis. Early was defined ≥5% accumulation occurring the first 24 hours of PICU admission. The maximum during next 6 days patients at least 48 stay PICU-acquired overload. fluctuation calculated difference between minimum obtained 7 after admission.Of...
Sepsis is regarded as arising from an unusual systemic response to infection but the physiopathology of sepsis remains elusive. At present, still a fatal condition with delayed diagnosis and poor outcome. Many biomarkers have been reported in clinical application for patients sepsis, claimed improve treatment. Because difficulty interpreting features some do not show high sensitivity specificity. MicroRNAs (miRNAs) are small noncoding RNAs which pair sites mRNAs regulate gene expression...
Mutations in isocitrate dehydrogenase (IDH) 1 or 2 are identified various cancers. Accumulated (R)-2-hydroxyglutarate (2-HG) caused by mutant IDHs leads to blockage of cell differentiation, thereby inducing malignant transformation. Herein we describe the medicinal chemistry efforts that discovered novel IDH inhibitor HMPL-306 (ranosidenib) via structure–activity relationship studies and pharmacokinetic optimization from internal hit compound 1. is a potent selective dual IDH1 2. It...
Abstract Autophagy is essentially a metabolic process, but its in vivo role nuclear radioprotection remains unexplored. We observed that ex autophagy activation reversed the proliferation inhibition, apoptosis and DNA damage irradiated hematopoietic cells. In improved bone marrow cellularity following radiation exposure. contrast, defective conditional mouse model worsened injury, reactive oxygen species (ROS) accumulation caused by Strikingly, an absence or reduction regulatory proteins...
Research on acute kidney injury (AKI) has focused identifying early biomarkers. However, whether AKI could be diagnosed in the absence of classic signs clinical and condition subclinical AKI, identified by damage or functional biomarkers oliguria increased serum creatinine (sCr) levels, is clinically significant remains to elucidated critically ill children. The aims study were investigate associations between urinary cystatin C (uCysC) levels mortality determine uCysC-positive associated...
Overexpression of cyclin D1 dependent kinases 4 and 6 (CDK4/6) is a common feature many human cancers including leukemia. LEE011 novel inhibitor both CDK4 6. To date, the molecular function in leukemia remains unclear.Leukemia cell growth apoptosis following treatment was assessed through CCK-8 annexin V/propidium iodide staining assays. Cell senescence by β-galactosidase p16INK4a expression analysis. Gene profiles treated HL-60 cells were investigated using an Arraystar Human LncRNA array....
Super enhancers (SEs) are genomic regions comprising multiple closely spaced enhancers, typically occupied by a high density of cell-type-specific master transcription factors (TFs) and frequently enriched in key oncogenes various tumors, including neuroblastoma (NB), one the most prevalent malignant solid tumors children originating from neural crest. Cyclin-dependent kinase 5 regulatory subunit-associated protein 3 (CDK5RAP3) is newly identified super-enhancer-driven gene regulated TFs NB;...
Pancreaticobiliary maljunction (PBM) is often associated with congenital choledochal cyst, protein plugs and pancreatitis. Early diagnosis timely treatment largely depend on imaging. We assessed a series of PBM in children, comparing imaging procedure histological pathological findings regard to diagnosis.A retrospective analysis was conducted 75 pediatric patients PBM. defined as common channel at >5 mm. Two radiologists assess the shape bile duct gallbladder, pancreatitis, surgical...
Abstract Background To identify radiomic features that can predict the pathological type of neuroblastic tumor in children. Methods Data on tumors 104 children were retrospectively analyzed. There 14 cases ganglioneuroma, 24 ganglioneuroblastoma, and 65 neuroblastoma. Stratified sampling was used to randomly allocate into training validation sets a ratio 3:1. The maximum relevance–minimum redundancy algorithm top 10 two clinical 851 portal venous–phase contrast-enhanced computed tomography...
Abstract Background Posterior shoulder dislocation is an uncommon orthopaedics injury and frequently missed or misdiagnosed, accounting for 2%-4% of all dislocations, associated with the reverse Hill-Sachs lesion. Once posterior develops into a chronic disease, it will bring lot trouble to treatment, especially in repairing humeral defects. Surgical strategies are also developing innovating deal this injury, including transfer subscapularis tendon lesser tubercle, rotational osteotomy,...
Selection of the first dose for neonates in clinical trials is very challenging. The objective this analysis was to assess if a population pharmacokinetic (PK) model developed with data from infants adults predictive neonatal clearance and evaluate what age range prior PK needed informative modeling predict neonate exposure. Two sources 8 drugs were used develop models: (1) all patients > 2 years age, (2) nonneonatal aged 28 days. prediction error based on models using subjects showed bias...
Fully understanding the developmental process of hepatic stem cells (HSCs) and mechanisms their committed differentiation is essential for optimizing generation functional hepatocytes cell therapy in liver disease. Delta-like 1 homolog (Dlk1), primarily membrane-bound form (Dlk1M), generally used as a surface marker fetal isolation, while its soluble (Dlk1S) roles different Dlk1 isoforms HSC remain to be investigated. Hepatic spheroid-derived (HSDCs) were isolated from E12.5 mouse livers...