A5068523570- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Advanced biosensing and bioanalysis techniques
- Gastrointestinal Tumor Research and Treatment
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Colorectal Cancer Surgical Treatments
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Virus-based gene therapy research
- Ferroptosis and cancer prognosis
- Animal Virus Infections Studies
- Lung Cancer Diagnosis and Treatment
- MicroRNA in disease regulation
Army Medical University
2016-2025
Shenzhen Institutes of Advanced Technology
2016-2025
Chinese Academy of Sciences
2016-2025
Nanjing Medical University
2018-2025
Daping Hospital
2015-2024
Jiangsu Provincial Center for Disease Control and Prevention
2024
Huzhou University
2016-2024
Cancer Hospital of Chinese Academy of Medical Sciences
2024
University of Chinese Academy of Sciences
2024
Zhejiang Cancer Hospital
2024
Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve ESCC were randomized (1:1) to receive toripalimab or placebo in combination paclitaxel plus cisplatin (TP) every weeks up 6 cycles, followed by maintenance. At prespecified final analysis of progression-free survival (PFS), a significant improvement PFS observed arm over (hazard ratio...
Importance For patients with non–small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited. Objective To compare the efficacy of ivonescimab plus chemotherapy alone for relapsed advanced or metastatic epidermal growth factor receptor ( ) variant. Design, Setting, and Participants Double-blind, placebo-controlled, randomized, phase 3 trial at 55 sites in China...
Abstract Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes oxidative stress responses, tumor progression chemoresistance. However, the molecular mechanisms underlying role these processes are still unclear. Recent findings point to novel RNA metabolism. Through characterization interactomes with other proteins, we demonstrate here for pri-miRNA processing via association DROSHA-processing complex during genotoxic...
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due the risk harm fetus. In placental malaria, Plasmodium falciparum-infected erythrocytes (IEs) accumulate in placenta by adhering chondroitin sulfate A (CSA) on surfaces trophoblasts. Based this principle, we have developed a method for targeted delivery payloads using synthetic CSA-binding peptide (plCSA-BP) derived from VAR2CSA, protein expressed IEs. Methods: biotinylated plCSA-BP...
ABSTRACT Ovarian endometrioma (OEM), a particularly severe form of endometriosis, is an oestrogen‐dependent condition often associated with pain and infertility. The mechanisms by which OEM impairs fertility, through its direct impact on oocyte‐cumulus cell (CC) communication related pathways, remain poorly understood. This study investigates the oocyte‐CC explores melatonin's therapeutic potential. We used mouse model employed ovarian transcriptome gene set enrichment analyses to identify...
Abstract Background Hyperlactatemia upon admission is a documented risk factor for mortality in critically ill adult patients. However, the predictive significance of single lactate measurement at general population children remains uncertain. This study evaluated value blood levels and determined cut-off values predicting in-hospital pediatric population. Methods We enrolled 1109 who were admitted to intensive care unit between July 2008 December 2010. Arterial samples collected first 2...
β-Glucans have been shown to reduce the risk of obesity and diabetes. However, they often contain diverse polysaccharides other ingredients, leading elusive experimental data mechanisms. In this study, a pure β-glucan was obtained from crude Baker's yeast for investigating its effect on metabolic disorders in high-fat diet induced obese (DIO)/type 2 diabetic (T2D) mice underlying mechanism.The Fourier transform infrared spectroscopy nuclear magnetic resonance indicated that (BYGlc) linear...
Baker's yeast glucan (BYG) has been reported to be an anti-diabetic agent. In the work described herein, further study on effect of orally administered BYG glucose and lipid homeostasis in livers ob/ob mice was performed. It found that decreased blood hepatic disorders. Western blotting analysis revealed up-regulated p-AKT p-AMPK, down-regulated p-Acc liver. Furthermore, RNA-Seq indicated genes responsible for gluconeogenesis (G6pase Got1), fatty acid biosynthesis (Acly, Acc, Fas, etc.),...
Background: Dyslipidemia is one of the modifiable risk factors for cardiovascular diseases (CVD). Identifying subjects with lipid abnormality facilitates preventative interventions. Objectives: To evaluate effects indices on risks ischemic stroke (IS), coronary heart disease (CHD), CVD, all-cause death, and CVD death. Methods: The cohort study 4,128 started in May 2009 followed up to July 2020. Restricted cubic spline (RCS) regression analysis was used explore dose-response relationship...
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1) protects cells from oxidative stress via the base excision repair pathway and as a redox transcriptional coactivator. It is required for tumor progression/metastasis, its up-regulation associated with cancer resistance. Loss of APE1 expression causes cell growth arrest, mitochondrial impairment, apoptosis, alterations intracellular state cytoskeletal structure. A detailed knowledge molecular mechanisms regulating different activities...
Apurinic/apyrimidinic endonuclease 1 (APE1), which has the dual functions of both DNA repair and redox activity, been reported to be highly expressed in non-small cell lung cancer (NSCLC), this appears a characteristic related chemotherapy resistance. In study, we identified serum APE1 autoantibodies (APE1-AAbs) NSCLC patients healthy controls by immunoblotting investigated expression APE1-AAbs indirect ELISA from 292 300 controls. addition, level alterations 91 were monitored before after...
Base excision repair (BER) handles many forms of endogenous DNA damage, and apurinic/apyrimidinic endonuclease 1 (APE1) is central to this process. Deletion both alleles APE1 (a.k.a. Apex1) in mice leads embryonic lethality, deficiency cells can promote cell death. Unlike most other BER proteins, expression inversely correlated with cellular senescence primary human fibroblasts. Depletion via shRNA induced normal BJ fibroblasts, a phenotype that was not seen counterpart expressing...
The 2015 World Health Organization classification defines pulmonary large-cell neuroendocrine carcinoma (LCNEC) as a high-grade carcinoma. However, the clinical characteristics and prognostic factors of pure LCNEC combined remain unclear. Hence, we performed multi-center retrospective study to compare outcomes versus LCNEC.Data from 381 patients with admitted 17 Chinese institutes between 2009 2016 were collected retrospectively. Clinical prognosis analyzed among receiving adjuvant (adjuvant...
Maternal circulating levels of the adipokine chemerin are elevated in preeclampsia, but its origin and contribution to preeclampsia remain unknown. We therefore studied (1) placental expression release human pregnancy, (2) consequences overexpression via lentivirus-mediated trophoblast-specific gene manipulation both mice immortalized trophoblasts. Placental were increased women with their correlated positively soluble Fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio,...