A5101772950- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Growth Hormone and Insulin-like Growth Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- TGF-β signaling in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Neonatal Health and Biochemistry
- Atrial Fibrillation Management and Outcomes
- Metabolism, Diabetes, and Cancer
- Cardiac Structural Anomalies and Repair
- RNA modifications and cancer
- Pituitary Gland Disorders and Treatments
- Connective tissue disorders research
- Genetic Associations and Epidemiology
- Cardiac tumors and thrombi
- Folate and B Vitamins Research
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
Yixing People's Hospital
2016-2025
Jiangsu University
2016-2025
Thrombolysis in Myocardial Infarction Study Group
2022
Weatherford College
2022
Ulsan University Hospital
2016
University of Ulsan
2016
Ulsan College
2016
National Institutes of Health
2013
Abstract Aim The present study aimed to assess the benefits of two-stent techniques for patients with DEFINITION criteria-defined complex coronary bifurcation lesions. Methods and results In total, 653 lesions at 49 international centres were randomly assigned undergo systematic technique (two-stent group) or provisional stenting (provisional group). primary endpoint was composite target lesion failure (TLF) 1-year follow-up, including cardiac death, vessel myocardial infarction (TVMI),...
Background: Dyslipidemia is one of the modifiable risk factors for cardiovascular diseases (CVD). Identifying subjects with lipid abnormality facilitates preventative interventions. Objectives: To evaluate effects indices on risks ischemic stroke (IS), coronary heart disease (CHD), CVD, all-cause death, and CVD death. Methods: The cohort study 4,128 started in May 2009 followed up to July 2020. Restricted cubic spline (RCS) regression analysis was used explore dose-response relationship...
Abstract Background Dyslipidemia and inflammation are significant factors for the onset of cardiovascular diseases (CVD); however, studies regarding their interactions on risk CVD scarce. This study aimed to assess interaction dyslipidemia high-sensitivity C-reactive protein (hs-CRP) CVD. Methods prospective cohort enrolled 4,128 adults at baseline in 2009 followed them up until May 2022 collecting events. Cox-proportional hazard regression analysis estimated ratios (HRs) 95% confidence...
Previous studies have linked platelet-derived growth factors (PDGFs) and their receptor beta (PDGFRB) genetic variants to coronary artery disease (CAD), but impact on major adverse cardiovascular events (MACEs) remains unclear. A cohort study of 3139 patients with CAD followed up until December 1, 2022 (median 5.42 years), genotyped 13 tagSNPs in PDGFs/PDGFRB pathway genes establish weighted risk scores (wGRS). Multiple Cox regression models analyzed the association SNPs wGRS MACE outcomes...
Abstract Objectives Whether high sensitivity C-reactive protein (hs-CRP) has a causal effect on coronary heart disease (CHD) is unclear. This study investigated the of hs-CRP CHD risk using Mendelian Randomization (MR) analysis. Methods A total 3802 subjects were recruited in follow-up study. Linear regression model was used to evaluate relationship between CRP polymorphisms and hs-CRP. Survival receiver operator characteristic curve method explore cut-off incidence. Cox applied detect...
Dyslipidemia and hypertension are both important risk factors for atherosclerotic cardiovascular diseases. However, the relationship between dyslipidemia incident remains to be elucidated comprehensively. The main purpose of this study was construct lipid score explore prediction effect integrated indices on new-onset hypertension.This prospective cohort with 2116 non-hypertensive subjects conducted from 2009 2020. New events during follow-up period were recorded verified. calculated by...
An animal study reported that TGF-β1 maturation was linked to the homeostasis of blood pressure and elastogenesis essential hypertension (EH). Recent advances require further research receptor in EH.A case-control comprised 2,012 adult case patients 2,210 control subjects conducted, association with tested children. Logistic regression calculated genetic risk score were used evaluate effects one single nucleotide polymorphism (SNP) multiple SNPs on EH, respectively.The 10 showed a...
β-actin (ACTB) participates in the vascular remodeling and contributes to cardiovascular diseases. Herein, we investigated associations of ACTB with hypertension stroke.
Background: High-mobility group box 1 protein (HMGB1) acts as a proinflammatory cytokine by activating pattern recognition receptors (PRRs), including Toll-like receptor 4 (TLR4) and the of AGE (AGER) with oxidative injury. Animal study proved that HMGB1 contributed to pathogenesis experimental pulmonary hypertension (HT) via activation TLR4. The aim this is test whether harbor genetic susceptibility HT in Chinese population. Methods: A case–control comprising 2012 cases 2210 controls was...
DIAPH1 is a formin protein involved in actin polymerization with important roles vascular remodeling and thrombosis.To investigate potential associations of single-nucleotide polymorphisms (SNPs) hypertension stroke, 2,012 patients 2,210 controls, 2,966 stroke cases [2,212 ischemic (IS), 754 hemorrhagic (HS)] 2,590 controls were enrolled respectively the casecontrol study.A total 4,098 individual included cohort study.DIAPH1 mRNA expression was compared between 66 IS [43 small artery...
Total bilirubin is beneficial for protecting cardiovascular diseases in adults. The authors aimed to investigate the association of total bilirubin, red blood cell, and hemoglobin levels with prevalence high pressure children adolescents. A 3776 students (aged from 6 16 years old) were examined using cluster sampling. Pre-high respectively defined as point 90th 95th percentiles based on Fourth Report Diagnosis, Evaluation, Treatment High Blood Pressure Children Adolescents. Both systolic...
Objectives The hypertriglyceridemic waist phenotype has been reported as a practical tool to screen people with an increased risk of coronary artery disease and type 2 diabetes. aim this study was investigate the relationship between ischemic stroke in rural population south China. Materials methods A total 4081 participants aged over 35 years old without history were surveyed 2009 followed up from May 2014 January 2016. defined circumference ≥90 cm triglyceride level ≥2.0 mmol/L males, ≥85...
// Zhengmei Fang 1, * , Song Yang 2, Lijun Zhu 1 Ying Li 3 Yanchun Chen 2 Yuelong Jin Xianghai Zhao Hailong 4 Xiaotian Yanping 5 Chong Shen and Yingshui Yao Department of Epidemiology Biostatistics, School Public Health, Wannan Medical College, Wuhu 241001, China Cardiology, Affiliated Yixing People's Hospital Jiangsu University, City, 214200, Epidemiology, Nanjing 211166, Central Laboratory, Neurology, These authors have contributed equally to this work Correspondence to: Shen, email:...
The study sought to investigate the clinical predictive value of quantitative flow ratio (QFR) for long-term outcome in patients with heavily calcified lesions who underwent percutaneous coronary intervention (PCI) following rotational atherectomy (RA).In this retrospective study, 393 consecutive from 2009 2017 were enrolled. QFR entire target vessel (QFRv) and stent plus 5 mm proximally distally (in-segment) (QFRi) measured. primary endpoint was lesion failure (TLF), including...
Abstract BACKGROUND Insulin-like growth factor 1 (IGF-1) and IGF-1 receptor (IGF-1R) have been suggested to mediate the pathophysiological response elevated blood pressure. This study aims evaluate association of IGF-1R with hypertension. METHODS Overall, 2,012 hypertensive cases 2,210 controls were included in a case–control study, 10 tagging single nucleotide polymorphisms (tagSNPs) selected. The these SNPs hypertension was further evaluated follow-up analysis an adolescent population....
Introduction Provisional stenting (PS) for simple coronary bifurcation lesions is the mainstay of treatment. A systematic two-stent approach widely used complex (CBLs). However, a randomised comparison PS and techniques CBLs has never been studied. Accordingly, present study designed to elucidate benefits treatment over in patients with CBLs. Methods analysis This DEFINITION II prospective, multinational, randomised, endpoint-driven trial compare technique total 660 will be 1:1 fashion...