A5103029779- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiomyopathy and Myosin Studies
- Chromatin Remodeling and Cancer
- Atrial Fibrillation Management and Outcomes
- Peptidase Inhibition and Analysis
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cardiac Fibrosis and Remodeling
- Antiplatelet Therapy and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Cancer-related gene regulation
- Phytochemical compounds biological activities
- Healthcare and Venom Research
- Climate Change and Health Impacts
- Hip and Femur Fractures
- Trypanosoma species research and implications
- Treatment of Major Depression
- Protease and Inhibitor Mechanisms
- Oropharyngeal Anatomy and Pathologies
Nanjing Medical University
2011-2024
Second Affiliated Hospital of Nanjing Medical University
2022-2023
PowerChina (China)
2021
Institute of Cardiology
2021
Sir Run Run Shaw Hospital
2017
Nanjing University
2009
Sun Yat-sen University
2007-2008
The First Affiliated Hospital, Sun Yat-sen University
2007
Chinese People's Armed Police Force
2005
Despite considerable therapeutic advances, there is still a dearth of evidence on the molecular determinants cardiac hypertrophy that culminate in heart failure. Neuraminidases are family enzymes catalyze cleavage terminal sialic acids from glycoproteins or glycolipids. This study sought to characterize role neuraminidases pathological and identify pharmacological inhibitors targeting mammalian neuraminidases.Neuraminidase 1 (NEU1) was highly expressed hypertrophic hearts mice rats, this...
Background: The importance of intravascular ultrasound (IVUS)-guided stenting the unprotected left main coronary artery (ULMCA) remains controversial and has not been fully studied in subset patients with ULMCA. This study evaluated clinical outcome IVUS-guided using a drug-eluting stent for Methods: A total 1,016 consecutive ULMCA stenosis who underwent implantation from January 2006 to December 2011 were prospectively registered. primary endpoint this nonrandomized registry was rate...
Objective: To determine the relationship between obesity and risk of AKI after cardiac surgery (CS-AKI) in a cohort study. Methods: A total 1,601 patients undergoing were collected their incidence CS-AKI recorded. They divided into underweight, normal weight, overweight, obese groups. Logistic regression was used to estimate association BMI (body mass index) risk. Then meta-analysis published studies conducted confirm this result using PubMed Embase databases. Results: significant observed...
Abstract Recent interest in adverse effects of infrasound on organisms arises from health concerns. We assessed the association between exposure 5 Hz at 130 dB and changes cardiac ultrastructure function rats. Thirty‐two Sprague–Dawley rats were randomized into control, 1, 7, 14 days groups for 2 h once daily according to planned schedules. Changes ultrastructure, hemodynamics indices, intracellular Ca 2+ concentrations ([Ca ] i ), sarcoplasmic reticulum ‐ATPase (SERCA2) detected. Heart...
Abstract Vascular inflammation is the culprit for a host of human diseases. The underlying mechanism, however, not definitively elucidated. In present study, we investigated interplay between different epigenetic factors during lipopolysaccharide (LPS) induced synthesis proinflammatory cytokines in cultured vascular endothelial cells. We report that response to LPS treatment, NF‐κB was deplored its target promoters along with chromatin remodeling protein BRG1. Paralleling these changes...
Background: Patients with diabetes have a two-to four-fold increased incidence of cardiovascular diseases compared non-diabetics. Currently, there is no recognized model to predict the occurrence and progression CVDs in diabetics. Objective: This work aimed develop metabolic biomarker-assisted model, combination markers clinical variables, for risk prediction Methods: A total 475 patients were studied. Each patient underwent coronary angiography. Plasma samples analyzed by liquid...
Patients with pre-existing chronic diseases are more susceptible to coronavirus disease 2019 (COVID-19), yet the underlying causes of increased risk infection remain unclear. Angiotensin-converting- enzyme 2 (ACE2), cell surface receptor that recognizes spike protein has protective effects against inflammation and hyperglycemia in animal models. The roles ACE2 severe SARS-CoV-2 infections remains ambiguous due contradictory findings. In this study, we aimed investigate relationship between...
Abstract As a traditional plant medicine in tropical areas, Swietenia macrophylla seeds are usually applied for some chronic diseases, including hypertension, diabetes, and so on. Few studies have been carried out to identify the effective elements seed extract their indications. In this study, we first investigated functions of swietenine, an from S. seeds, using model myocardial hypertrophy induced by isoprenaline (ISO). At cellular level, H9c2 cell was also established through treatment...
The primary site of infection in COVID-19 exhibit is the respiratory system, but multiple organ systems could be affected. virus directly invade cardiomyocytes. Alternatively, cytokine storm lead to myocardial injury. More importantly, management existing cardiovascular diseases must re-examined due to, for example, interaction between antiviral agents and with a wide variety pharmacological agents. Branch Cardiovascular Physicians Chinese Medical Doctor Association organized panel experts...
This meta-analysis aimed to assess the association of polymorphisms cholesterol ester transfer protein (CETP) rs708272 (G>A), rs5882 rs1800775 (C>A), rs4783961 rs247616 (C>T), rs5883 rs1800776 and rs1532624 (C>A) with coronary artery disease (CAD) related underlying mechanisms.A comprehensive search was performed using five databases such as PubMed, EMBASE, Web Science, Cochrane Library Scopus obtain appropriate articles. The quality included studies assessed by Newcastle-Ottawa Scale....
Rheumatic heart disease (RHD) occurs due to the accumulation of complications associated with rheumatic fever, and it results in high morbidity mortality. The majority cases RHD are diagnosed chronic stages, when treatment options limited. A small reservoir cardiac stem cells is responsible for maintaining homeostasis repairing tissue damage. Understanding role various proteins their functions different pathological stages an important area investigation. Polycomb complex protein BMI‑1...
BACKGROUNDSubclavian steal syndrome (SSS) caused by Sjogren's is rare, especially for elderly patients with risk factors atherosclerosis.The current report presents the uncommon etiology and treatment of SSS, aiming to improve doctor's clinical experience. CASE SUMMARYA 69-year-old man was diagnosed hypertension acute cerebral infarction presenting left upper limb weakness pain even gradually aggravating hemiplegia 30 years ago.He managed antihypertensive antithrombotic therapy; however, his...