A5102446624- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Gastrointestinal motility and disorders
- Spondyloarthritis Studies and Treatments
- Cervical and Thoracic Myelopathy
- Pancreatic and Hepatic Oncology Research
- Hematological disorders and diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Systemic Lupus Erythematosus Research
- MRI in cancer diagnosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Acute Myocardial Infarction Research
- Scoliosis diagnosis and treatment
- Atrial Fibrillation Management and Outcomes
- Advanced Breast Cancer Therapies
- Lysosomal Storage Disorders Research
- Calcium signaling and nucleotide metabolism
- Ferroptosis and cancer prognosis
- Cervical Cancer and HPV Research
- Fractional Differential Equations Solutions
Third People's Hospital of Yunnan Province
2025
Nanjing Jiangning Hospital
2025
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Beijing Xuanwu Traditional Chinese Medicine Hospital
2024
Dalian Medical University
2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Yuhuangding Hospital
2024
Capital Institute of Pediatrics
2021-2024
Background Intervertebral disc degeneration (IVDD) is a prominent contributor to chronic low back pain, impacting millions of individuals annually. Current research on placing growing emphasis the role immune system in this process. Nevertheless, precise relationship between immunity and remains be fully elucidated. Method We obtained GWAS data for cells from latest summary-level GWAS, including 6,620 Sardinian 746,667 five global populations. Summary results IVDD were sourced FinnGen...
Alcohol addiction can cause brain dysfunction and threatens both individuals society. Recently, emerging studies have suggested the dysbiosis of gut microbiota induced by alcohol exposure contributed to reward-seeking behaviors as well anxiety, depression. In current study, animal model chronic was established providing mice with gradient concentrations from 2%, 4%, 6% 8% for 21 days. Moreover, three fecal transplantation (FMT) plans were innovatively designed explore potential effects FMT 3...
High-risk human papillomavirus (HPV) infection is strongly linked to the initiation and progression of cervical cancer, yet precise molecular mechanisms involved remain partially understood. This investigation examined differential protein expression profiles in various cohorts, including healthy controls HPV-positive cancer patients with different levels glucose-6-phosphate dehydrogenase (G6PD), shedding light on dysregulation oncogenic proteins by HPV. Proteomic analysis tissues revealed...
This study explores the association between need for open necrosectomy (ON) during infected necrotizing pancreatitis (INP) treatment and development of postoperative pancreatic fistula (POPF) following definitive surgery (DS) transverse colonic fistulas. was conducted at two tertiary hospitals included patients who underwent DS secondary to INP from January 2009 December 2023. Patients were followed until hospital discharge. The primary outcome incidence POPF. A total 135 included. median...
Background Elderly surgical patients are at high risk of perioperative sleep disturbances (PSD), and the underlying pathogenic mechanisms remain unclear. The relationship between peripheral inflammatory status PSD pathogenesis currently lacks substantial clinical evidence. Objective This study aims to evaluate association inflammation indicators in elderly undergoing laparoscopic hepatobiliary surgery, analyze dynamic changes throughout period. Method materials Using retrospective data, this...
<title>Abstract</title> Veno-occlusive disease (VOD) is a severe adverse reaction to busulfan-containing regimens used in the preparation of children for hematopoietic stem cell transplantation (HSCT). We previously found that youngest have greater risk VOD, and high busulfan C<sub>max</sub> more likely occur after first two doses. conducted retrospective pharmacokinetic analysis IV (intravenous) infants undergoing (HSCT) described its relation outcomes. Thirty-four (median age, 8.5 months)...
Background Ankylosing spondylitis (AS) is an autoimmune disease that affects millions of individuals. Immune cells have been recognized as having a crucial role in the pathogenesis AS. However, their relationship has not fully explored. Methods We chose to employ Mendelian randomization (MR) investigate potential correlation between immune and sourced data on from latest genome-wide association studies (GWASs). obtained AS FinnGen consortium. Our comprehensive univariable MR analysis covered...
This study aims to introduce a two-stage surgical procedure, namely oblique lateral interbody fusion (OLIF), for spinal disorders treatment. Furthermore, clinical outcomes and imaging results are analyzed between OLIF with posterior fixation lumbar (PLIF) lumbosacral curve-driven degenerative scoliosis (DLS). 146 patients type 2 DLS who underwent or PLIF January 2019 November 2023 were included. Spinal pelvic parameters measured using X-ray before after surgery. Clinical symptoms assessed...
This retrospective analysis evaluated the use of anti-thymocyte globulin (ATG) with or without post-transplantation cyclophosphamide (PTCy) for graft-versus-host disease (GvHD) prophylaxis in children acute leukemia undergoing hematopoietic stem cell transplantation (HSCT). The study included 57 children, 35 ATG-PTCy group and 22 ATG group. While overall incidence chronic GvHD did not differ significantly between groups, had lower rates grade II-IV (p = 0.013) moderate-to-severe 0.001)...
The primary site of infection in COVID-19 exhibit is the respiratory system, but multiple organ systems could be affected. virus directly invade cardiomyocytes. Alternatively, cytokine storm lead to myocardial injury. More importantly, management existing cardiovascular diseases must re-examined due to, for example, interaction between antiviral agents and with a wide variety pharmacological agents. Branch Cardiovascular Physicians Chinese Medical Doctor Association organized panel experts...
To investigate the efficacy and safety of haploidentical hematopoietic stem cell transplantation (haplo-HSCT) in combination ATG post-transplant cyclophosphamide (PTCy) -induced immune tolerance after treatment childhood myelodysplastic syndromes(MDS）.From July 2016 to November 2020, a total 8 children with MDS receiving allo-HSCT combined PTCy-induced our hospital were enrolled, whose clinical data retrospected analyzed.Median age at diagnosis (1 male 7 females) was 6.4 (range, 10 months 15...
Abstract Background: Patients with local advanced esophageal squamous cell carcinoma (ESCC) benefited from neoadjuvant immunochemotherapy (NAI) 22%-55% of complete pathological responses (pCR). While unpredicted therapeutic resistance hampered prognosis these patients. Thus, this study aimed to investigate tumor microenvironment (TME) remodeling pre- and post-NAI identifying predictive biomarkers potential targets for patients NAI. Methods: 65 locally ESCC, who were treated anti-PD-1...
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Bone mineral density (BMD) and monocyte-to-lymphocyte ratio (MLR) were recently identified as novel risk factors for patients with several malignancies. The objective of this study was to validate the role preoperative BMD/MLR a potential prognostic biomarker in hepatocellular carcinoma (HCC) undergoing liver resection.
To evaluate the feasibility, safety, and early effectiveness of percutaneous endoscopic thoracic spine surgery via trench technique for ventral decompression in central calcified disc herniation (CCTDH) ossification posterior longitudinal ligament (T-OPLL). Seven patients with single-segment CCTDH or T-OPLL admitted between June 2017 May 2020 meeting selection criteria were retrospectively analyzed. There 3 males 4 females an average age 51.7 years ranging from 41 to 62 years. 2 (T 1, cases)...
A novel accurate method is proposed to solve a broad variety of linear and nonlinear (1+1)-dimensional (2+1)dimensional multi-term time-fractional partial differential equations with spatial operators anisotropic diffusivity.For problems, analytical solutions that satisfy the boundary requirements are derived.Such numerically calculated using trigonometric basis approximation for (2+1)-dimensional problems.With aid these or numerical approximations, original problems can be converted into...
Objective To investigate the iodine intake level and prevalence of thyroid nodules in Harbin City, to study correlation between concentration urinary nodules. Methods In Harbin, 18 communities were randomly selected specimens collected from fasting morning urine 2015 2017. The (UIC) was detected by arsenic cerium catalytic spectrophotometry, nodule examined B ultrasound. Results A total 2 552 residents aged (45.79 ± 12.06) years old agreed participate study, including 371 males...