Abstract Cancer stem cells are implicated in resistance to ionizing radiation (IR) and chemotherapy. Honokiol, a biphenolic compound has been used traditional Chinese medicine for treating various ailments. In this study, we determined the ability of honokiol enhance sensitivity colon cancer IR. The combination IR suppressed proliferation colony formation while inducing apoptosis culture. There were also reduced numbers size spheroids, which was coupled with expression cell marker protein...

Abstract Recently, increasing evidence has indicated lncRNAs are powerful regulators in the progression of multiple tumors. Dysregulation lncRNA NEAT1 been recognized many cancer types. Meanwhile, studies on function have suggested that can serve as a crucial oncogene. Nevertheless, investigation colon is still few. In our study, was studied cancer. As we observed, level obviously elevated cells. Then, HCT‐116 and SW620 cells were stably infected with shRNA‐NEAT1 for 48 hr. exhibited,...

Members of eukaryotic chaperonin family are essential for cell survival. Dysregulation Chaperonin containing TCP-1 subunit 3 (CCT3) has been implicated in the development several types cancers. However, role CCT3 gastric cancer yet to be determined.The expression patterns surgical specimens from 26 patients were evaluated using immunohistochemistry methods. To study possible roles growth and survival cells, RNA interference was used knockdown lines BGC-823 MGC-803. The effects on...

This study aimed to identify potential biomarkers and the therapeutic targets for colorectal adenocarcinoma by systematically evaluate a large scale of long noncoding RNAs (lncRNAs) expression data from TCGA. The algorithm t-distributed stochastic neighbor embedding hierarchical clustering were utilized group samples into three clusters that showed different prognosis. To relationship between clustered groups histoclinical features, statistical methods used. functions LINC01234 MIR210HG...

Colorectal cancer remains as a serious global cause of morbidity and mortality. The current therapies for colorectal treatment are still unsatisfactory thus, identification novel targets is an urgent requisite. Recent evidence has reported miRNAs closely correlated with development. miR-150 been identified in tumor progression various cancers. Nevertheless, its roles remain poorly known. In our study, decreased expression tissues cells was observed. Meanwhile, we negative correlation between...

DNA mismatch repair is required for correcting any mismatches that are created during replication and recombination, a defective system contributes to damage-induced growth arrest. The colorectal cancer cell line HCT116 known have mutation in the hMLH1 gene resulting microsatellite instability repair. Honokiol biphenolic compound has been used traditional Chinese medicine treating various ailments including cancer. This study was designed test hypothesis honokiol enhances radiosensitivity of...

Abstract Long noncoding RNAs play essential roles in colon cancer tumorigenesis. This study aimed to explore the potential function and molecular mechanisms of LINC00961 cancer. qPCR results showed that was downregulated cells tissues. Functional assays demonstrated suppressed migration invasion vitro. functioned as an endogenous sponge for miR‐223‐3p cells. SOX11 confirmed a target gene miR‐223‐3p. The effect on then investigated. MiR‐223‐3p inhibition enhanced their invasion. studied....

Transcription terminators play a role in terminating the progress of gene transcription, and are thus essential elements circuit. Terminators have two main functions: transcription improving stability transcripts during translation. We therefore considered detailed characteristics relation to their different roles translation, including shut-down degree (α) upstream mRNA protection capacity (β), apparent termination efficiency (η) reflecting overall regulatory effect terminator. Based on...

Gastric cancer, characterized by a multifactorial etiology and high heterogeneity, continues to confound researchers in terms of its pathogenesis. Curcumin, natural anticancer agent, exhibits therapeutic promise gastric cancer. Its effects include promoting cell apoptosis, curtailing tumor angiogenesis, enhancing sensitivity radiation chemotherapy. Long noncoding RNAs (lncRNAs) have garnered significant attention as biomarkers for early screening, diagnosis, treatment, drug response because...

Clinical practice guidelines (CPGs) play an important role in health care. The guideline development process should be precise and rigorous to ensure that the results are reproducible not vague. To determine quality of guidelines, Appraisal Guidelines Research Evaluation (AGREE) instrument was developed introduced. objective this study is assess methodological CPGs on pancreatic cancer. Five databases (included MEDLINE EMBASE) websites were searched till April, 2014. assessed by 4 authors...

As a pilot research for an aimed beam-column joint of steel prefabricated prefinished volumetric construction (PPVC) buildings, this study investigates the axial static bearing capacity grouted square hollow section (SHS) sleeve connections via carrying out experimental tests. Ten specimens with different dimensions were tested to failure under monotonic compressive loading and their loading-displacement curves measured recorded. The effect length, shear-key spacing, grout strength SHS are...

Background: Breast cancer is the most frequently diagnosed in women worldwide. When treated by chemotherapy and/or radiotherapy, there are various non-pharmacological adjuvant therapies (NPATs) recommended for helping patients with breast alleviate multiple side effects induced radiotherapy and improve quality of life (QoL). However, existing evidence does not suggest therapy best effectiveness among a variety NPATs. This study to compare different NPATs on QoL using Bayesian network...

Aiming at the demand for a low-cost and precision robotic polishing force control device, this paper proposes new device driven by coupled active-passive compliant mechanism, whose active mechanism is composed of cylinder, while passive formed three springs. The designed between cylindrical dynamic/static platform, stiffness analyzed finite element method. Based on this, static model was analyzed, relationship cylinder air pressure output obtained, real-time obtaining based one-dimensional...

22164 Background: LDH is a biomarker of cellular turn over. The purpose our study was to identify serum as surrogate marker tumor burden and site metastatic disease in cancer patients. Methods: Data from 245 patients (mean age: 63.7 years, 53% F, 61.6% adenoca) were retrieved who treated between July 2005 December 2007. pts risk stratified stage: stage I: 25, II: 23, III: 92, IV: 105. ECOG performance status 0–2 142 pts, 3–4in 103 pts. All had CT scans for staging. LDH, hemoglobin, uric...

To investigate the geographical distribution and seasonal fluctuations of visceral leishmaniasis vectors sandflies in Henan Province 2023, so as to provide insights into prevention control vectors.