A5100386592- Genomics and Phylogenetic Studies
- Microbial Fuel Cells and Bioremediation
- Tissue Engineering and Regenerative Medicine
- Genetic diversity and population structure
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Lung Cancer Research Studies
- Bacterial biofilms and quorum sensing
- Microbial Community Ecology and Physiology
- Advanced biosensing and bioanalysis techniques
- Reproductive Biology and Fertility
- Plant Pathogenic Bacteria Studies
- RNA modifications and cancer
- Electrochemical sensors and biosensors
- Pharmacological Effects of Natural Compounds
- Pharmaceutical and Antibiotic Environmental Impacts
- Animal Behavior and Reproduction
- CRISPR and Genetic Engineering
- Electrohydrodynamics and Fluid Dynamics
- Plant Diversity and Evolution
- Antibiotic Resistance in Bacteria
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Electrospun Nanofibers in Biomedical Applications
- Vibrio bacteria research studies
- Supercapacitor Materials and Fabrication
CAS Key Laboratory of Urban Pollutant Conversion
2021-2024
University of Science and Technology of China
2015-2024
Chinese Academy of Fishery Sciences
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
High Magnetic Field Laboratory
2019-2024
Chinese Academy of Sciences
2003-2024
Hefei Institutes of Physical Science
2024
Jiangsu University
2021-2024
Innovation Team (China)
2024
Binzhou Medical University
2024
Core-shell structured stem cell microencapsulation in hydrogel has wide applications tissue engineering, regenerative medicine, and cell-based therapies because it offers an ideal immunoisolative microenvironment for delivery 3D culture. Long-term storage of such microcapsules as cell-biomaterial constructs by cryopreservation is enabling technology their distribution ready availability clinical transplantation. However, most the existing studies focus on single cells or without a core-shell...
Stem cells microencapsulated in hydrogel as stem cell-hydrogel constructs have wide applications the burgeoning cell-based medicine. Due to their short shelf life at ambient temperature, long-term storage or banking of is essential "off-the-shelf" ready availability needed for widespread applications. As a high-efficiency, easy-to-operate, low-toxicity, and low-cost method constructs, low-cryoprotectant (CPA) vitrification has attracted tremendous attention recently. However, we found many...
Ulcerative colitis (UC) is a recurrent chronic mucosal inflammation disease whose most significant pathological characteristics are intestinal and damaged barrier induced by reactive oxygen/nitrogen species, abnormal immune microenvironment, microecological imbalance. Oral probiotics living therapy for diseases, but their clinical application hindered poor bacterial biological activity insufficient retention. Here, we developed targeted oral formulation, functionalized probiotic Lf@MPB, with...
The active component-target network and protein-protein interaction of Compound Anshen essential oil were constructed. target functions related pathways analyzed to explore the mechanism in treatment insomnia. GC-MS was used detect chemical composition oil, TCMSP, STITCH, TTD, DrugBank databases searched predict screen targets Cytoscape software construct diagrams component-action networks, ClueGO analyze GO enrichment KEGG pathway target, systemsDock website database for molecular docking....
The purpose of this study was to evaluate the obesity preventing or relieving effect insoluble dietary fiber (IDF) from Pleurotus eryngii through its modulations on intestinal microbiota. IDF extracted and structurally characterized FTIR, X-Ray thermogravimetric (TG) analysis. mice for in vivo experiments were divided into group (feeding high-fat diet while gavage simultaneously) (IDF intervention after establishment obese model) hypolipidemic effect. Results: yield P. extracts 56.49% (on...
Two bacterial strains were isolated from methanogenic butyrate-oxidizing mixed cultures. The cells straight to slightly curved, Gram-positive rods that motile by means of multiple flagella and formed endospores. Growth was observed in the temperature range 15–45 °C (optimum 37 °C) pH 5·5–9·0 7·5). novel isolates strictly anaerobic chemo-organotrophs capable utilizing yeast extract, peptone, tryptone a variety sugars organic acids, but not glucose. None accessory electron acceptors tested...
Mobilized colistin resistance (mcr-1) gene mediated by plasmid can cause the speediness dissemination of colistin-resistant strains, which have given rise to a great threat treatment human infection. Hence, rapid and accurate diagnosis technology for detecting mcr-1 is essential control gene. Here, recombinase polymerase amplification (RPA) coupled with CRISPR/Cas12a platform was established rapid, sensitive, specific detection The analytical sensitivity our assay 420 fg per reaction in pure...
Male and female Chinese soft-shelled turtles (Pelodiscus sinensis) have sex-dimorphic growth patterns, males higher commercial value because of their larger size thicker calipash. Thus, developing sex-specific markers is beneficial to studies on all-male breeding in P. sinensis. Here, we developed an accurate efficient workflow for the screening sequences with ZW or XY sex determination systems. Based this workflow, male sinensis reference genomes 2.23 Gb 2.26 were obtained using de novo...
Foodborne pathogens and biofilm formation pose a critical threat to food safety. Pseudomonas aeruginosa is pathogen of interest in the industry. High-power pulsed microwave (HPPM) non-thermal technology with proven efficacy towards bacterial inactivation. This study investigated inactivation mechanisms performance different HPPM treatments (50, 100, 150, 200, 250 Hz for 3, 5, 7, 9, 11 min, respectively) identify optimum conditions inactivate P. PAO1 biofilms. The results showed significant...
Abstract PLK1 is currently at the forefront of mitotic research and has emerged as a potential target for small cell lung cancer (SCLC) therapy. However, factors influencing efficacy inhibitors remain unclear. Herein, BRCA1 was identified key factor affecting response SCLC cells to BI-2536. Targeting AURKA with alisertib, non-toxic concentration, reduced BI-2536-induced accumulation RAD51, leading DNA repair defects death in cells. In vivo experiments confirmed that combining BI-2536...
Abstract Knowledge of sex determination has important implications in physiology, ecology and genetics, but the evolutionary mechanisms systems turtles have not been fully elucidated, due to a lack reference genomes. Here, we generate high-quality genome assembly Asian yellow pond turtle ( Mauremys mutica ) using continuous long-read (PacBio platform), Illumina, high-throughput chromatin conformation capture (Hi-C) technologies. The M . haplotype size 2.23 Gb with contig N50 8.53 Mb scaffold...
Abstract: Male sexual orientation has been proposed to have genetic components, but previously suggested candidate genes all received negative results. The human sonic hedgehog ( SHH ) gene is located in the 7q36 region, which was linked male a previous genome‐wide association study. known play an important role embryo patterning, and there evidence connecting it orientation. In this study, we performed analysis of tag single nucleotide polymorphism rs9333613 361 subjects 319 Chinese...
A novel anaerobic, thermophilic, syntrophic, fatty-acid-oxidizing bacterium, strain L-60T, was isolated from a Chinese hot spring. Cells of the were non-motile, non-spore-forming, slightly curved rods. Growth occurred between 55 and 70 °C (optimum about 60 °C) at pH 7.0-9.3 8.2). Crotonate only tested carbon source that supported growth in pure culture. In co-culture with hydrogenotrophic Methanothermobacter thermautotrophicus DSM 1053T, isolate could oxidize saturated straight-chain fatty...
Quantitative evaluation of the inherent correlation between cell cryoinjuries and intracellular ice formation (IIF) together with recrystallization (IIR) is primary importance for both optimization biopreservation cryotherapy. The objective this study to thoroughly explore roles IIF on viability by using pig iliac endothelium cells (PIECs) as model during freezing thawing. experimental results indicated that probabilities (PIF) IIR (PIR) increased along increase cooling rates (p < 0.05)...