A5101553827- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cannabis and Cannabinoid Research
- Heart Failure Treatment and Management
- Respiratory Support and Mechanisms
Shanghai Jiao Tong University
2016-2025
Shanghai Chest Hospital
2018-2025
Sichuan Cancer Hospital
2024-2025
University of Electronic Science and Technology of China
2024-2025
Sichuan University
2023
West China Hospital of Sichuan University
2023
Chengdu Third People's Hospital
2022-2023
ShanghaiTech University
2022
Beijing Jiaotong University
2022
Southwest Jiaotong University
2022
Timely primary percutaneous coronary intervention (PPCI) cannot be offered to all patients with ST-segment-elevation myocardial infarction (STEMI). Pharmaco-invasive (PhI) strategy has been proposed as a valuable alternative for eligible STEMI. We conducted randomized study compare the efficacy and safety of PhI half-dose fibrinolytic regimen versus PPCI in STEMI.The EARLY-MYO trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI Acute ST-Segment-Elevation...
Endocannabinoid system is reported to be activated during myocardial ischemia-reperfusion (IR) injury and protects against heart injury. We, therefore, observed changes in endocannabinoids levels acute infarction (AMI) IR evaluated the role of cannabinoid-2 (CB2) receptor infarct In contrast 16 control patients with normal coronary artery angiogram, endocannabinoid 2-arachidonoylglycerol level infarct-side 23 AMI increased significantly, reactive oxygen species tumor necrosis factor-α both...
Background: Macrophages play an important role in cardiac repair after myocardial infarction (MI). In addition to the resident macrophages and blood-derived monocytes, Gata6 + cavity located pericardial space were recently reported relocate injured myocardium prevent fibrosis. However, there is no direct genetic evidence support it. Methods: We used dual recombinases (Cre Dre) specifically label (GPCMs) vivo. For functional study, we generated systems ablate GPCMs by induced expression of...
The safety and efficacy of a combined approach catheter ablation (CA) left atrial appendage occlusion (LAAO) compared to LAAO alone remain unknown. Patients with fibrillation (AF) at increased stroke risk who underwent were divided into either (CA LAAO) procedure or group. Propensity score matching was utilized balance baseline characteristics. primary endpoint the study composite death, thromboembolic events, major bleeding, heart failure (HF) rehospitalization periprocedural complications....
<title>Abstract</title> This study aims to investigate the changing patterns of burden for atrial fibrillation (AF) /atrial flutter (AFL) attributed high systolic blood pressure (SBP) in China. Data were sourced from Global Burden Disease (GBD) 2021 project. The disease AF /AFL SBP China 1990 was analyzed stratified by sex and age, along with trend prediction 2022 2050. In China, between 2021, age-standardized mortality rate (ASMR) disability-adjusted life years (DALYs) (ASDR) AF/AFL...
Liver cancer poses significant health challenges worldwide, particularly for ethnic minority populations, who often face barriers such as cultural differences, limited literacy, and inadequate access to healthcare, contributing poorer self-management treatment outcomes. Existing tools do not adequately address the unique needs of liver patients, necessitating development a culturally tailored assessment scale. Grounded in Health Belief Model, this study developed behavior scale specifically...
Although the pathogenesis of abdominal aortic aneurysm (AAA) remains largely unclear, evidence is accumulating to suggest systemic nature this disease. Here, we comprehensively assessed whole tree with its major branches based on computed tomography angiography (CTA) in AAA patients compared ascending thoracic (ATAA) and nonaneurysmal controls, as well an original mouse model Lkb1flox/flox;Myh11-Cre/ERT2 mice. The morphology dimensions aorta (at different levels) were among 47 patients, ATAA...
Evidence from recent studies suggests that the endocannabinoid system participates in regulation of lipid metabolism and body composition. We hypothesize is activated by oxidized low-density lipoprotein (oxLDL) regulates cellular cholesterol macrophages.Primary peritoneal macrophages isolated Sprague-Dawley rats RAW264.7 mice were cultured. A liquid chromatography/mass spectrometry (LC/MS) was used to measure anandamide (AEA), 2-arachidonoylglycerol (2-AG), levels macrophages. The regulatory...
The endocannabinoid system has recently been attracted interest for its anti-inflammatory and anti-oxidative properties. In this study, we investigated the role of in regulating oxidized low-density lipoprotein (oxLDL)-induced inflammatory response macrophages. RAW264.7 mouse macrophages peritoneal isolated from Sprague-Dawley (SD) rats were exposed to oxLDL with or without synthetic cannabinoid WIN55,212-2. To assess response, reactive oxygen species (ROS) tumor necrosis factor alpha (TNF-...
Background First generation drug-eluting stents (DES) were associated with a high incidence of late stent thrombosis (ST), mainly due to delayed healing and re-endothelization by the durable polymer coating. This study sought assess safety efficacy Nano polymer-free sirolimus-eluting (SES) in treatment patients de novo coronary artery lesions. Methods The trial is first randomized designed compare SES Partner durable-polymer (Lepu Medical Technology, Beijing, China) native primary endpoint...
Anthracycline generates progressive left ventricular dysfunction associated with a poor prognosis.The purpose of this study was to evaluate whether layer-specific strain analysis could assess the subclinical after exposure anthracycline.Forty-two anthracycline-treated survivors large B-cell non-Hodgkin lymphoma, aged 55.83 ± 17.92 years (chemotherapy group) and 27 healthy volunteers, 51.39 13.40 (control were enrolled. The cumulative dose epirubicin in chemotherapy group 319.67 71.71mg/m2....
This study assessed the incidence and risk factors (RFs) of postoperative atrial fibrillation (POAF) its impact on clinical outcomes in patients undergoing pneumonectomy for lung cancer.Between 2013 2018, this monocentric retrospective enrolled 324 consecutive primary cancer from our institution 350 lobectomy 349 segmentectomy cases matched by age, sex body mass index (BMI). RF POAF death were logistic regression, long-term after a median follow-up 30 (range, 2-61) months Cox proportional...
Abstract Feature tracking in cine cardiac magnetic resonance (CMR) is a quantitative technique to assess heart structure and function. We investigated 4-dimensional (4D) dynamics morphology of the mitral annulus (MA) using novel system based on radially rotational long-axis CMR series. A total 30 normal controls patients with regurgitation were enrolled. The spatiotemporal changes MA characterized by an in-house developed program. Dynamic morphological parameters extracted from all 18 radial...