A5101555321- RNA modifications and cancer
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- bioluminescence and chemiluminescence research
- Esophageal Cancer Research and Treatment
- Sexual function and dysfunction studies
- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Diet, Metabolism, and Disease
- CRISPR and Genetic Engineering
- Liver Disease Diagnosis and Treatment
- Hormonal and reproductive studies
- Cancer Mechanisms and Therapy
- Cellular transport and secretion
- RNA Interference and Gene Delivery
- Sodium Intake and Health
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Retinal and Macular Surgery
- Pharmacology and Obesity Treatment
- Retinopathy of Prematurity Studies
- Cancer-related gene regulation
Shandong First Medical University
2025
Shandong Tumor Hospital
2025
Affiliated Hospital of Southwest Medical University
2025
Yili Friendship Hospital
2024
University of Electronic Science and Technology of China
2024
Kailuan General Hospital
2019
Penn Presbyterian Medical Center
2012-2015
University of Pennsylvania
2002-2015
Abstract The occurrence of chemoresistance is an inescapable obstacle affecting the clinical efficacy cisplatin in gastric cancer (GC). Exploring regulatory mechanism resistance will help to provide potential effective targets for improving prognosis patients. Here, we find that FAM120A upregulated GC tissues and higher cisplatin-resistant tissues, its high expression positively correlated with poor outcome Functional studies indicate confers cells by inhibiting ferroptosis. Mechanically,...
Purpose.: To investigate in vivo inner and outer retinal microstructure effects of structural abnormalities on visual function patients with degeneration caused by ABCA4 mutations (ABCA4-RD). Methods.: Patients ABCA4-RD (n = 45; age range, 9–71 years) were studied spectral-domain optical coherence tomography (OCT) scans extending from the fovea to 30° eccentricity along horizontal vertical meridians. Thicknesses laminae analyzed. Serial OCT measurements available over a mean period 4 years...
We investigated the retinal disease due to mutations in retinitis pigmentosa GTPase regulator (RPGR) gene human patients and an Rpgr conditional knockout (cko) mouse model.XLRP with RPGR-ORF15 (n = 35, ages at first visit 5-72 years) had clinical examinations, rod cone perimetry. Rpgr-cko mice, which proximal promoter exon were deleted ubiquitously, back-crossed onto a BALB/c background, studied optical coherence tomography electroretinography (ERG). Retinal histopathology was performed on...
Abstract Background A high sodium intake is associated with obesity and metabolic syndrome. However, little known regarding whether greater salt a potential risk factor for non‐alcoholic fatty liver disease ( NAFLD ). We thus prospectively investigated individuals higher perceived dietary had of developing . Methods The present study included 35 023 participants (22 629 men 12 394 women) from the Kailuan who were free at baseline (2006) did not drink alcohol during follow‐up (2006–2014;...
Purpose: To characterize in detail the phenotype and genotype of patients with pericentral retinal degeneration (PRD). Methods: Patients were screened for an annular ring scotoma ranging from 3° to 40° (n = 28, ages 24–71) kinetic perimetry. All had pigmentary retinopathy region dysfunction. Further studies included cross-sectional en face imaging, static chromatic perimetry, electroretinography. Molecular screening was performed. Results: Genotypes 14 28 PRD identified: There mutations...
The endothelium is increasingly recognized as serving a critical role in maintaining circulatory homeostasis. Endothelial dysfunction evidenced an attenuation or exaggeration of the normal dynamic vasomotor range. Circulating endothelial progenitor cells (EPCs) are responsible for replenishment. When EPC recruitment insufficient after injury, pathophysiological ensues. Impaired function associated with myriad cardiovascular diseases including coronary artery disease, atherosclerosis,...