A5031045489- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac Structural Anomalies and Repair
- Signaling Pathways in Disease
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cardiac Arrhythmias and Treatments
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Cardiovascular Disease and Adiposity
- Advancements in Semiconductor Devices and Circuit Design
- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Platelet Disorders and Treatments
- Cardiac pacing and defibrillation studies
Shanghai Jiao Tong University
2015-2025
Ruijin Hospital
2025
Renji Hospital
2014-2024
Zhongshan Hospital of Xiamen University
2024
Fujian Medical University
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Binzhou University
2023
Binzhou Medical University
2023
State Key Laboratory of Oncogene and Related Genes
2020-2022
Shanghai Cancer Institute
2022
Timely primary percutaneous coronary intervention (PPCI) cannot be offered to all patients with ST-segment-elevation myocardial infarction (STEMI). Pharmaco-invasive (PhI) strategy has been proposed as a valuable alternative for eligible STEMI. We conducted randomized study compare the efficacy and safety of PhI half-dose fibrinolytic regimen versus PPCI in STEMI.The EARLY-MYO trial (Early Routine Catheterization After Alteplase Fibrinolysis Versus Primary PCI Acute ST-Segment-Elevation...
Background: Emerging studies have described and analyzed epidemiological, clinical, laboratory, radiological features of COVID-19 patients. Yet, scarce information is available regarding the association lipid profile disease severity mortality. Methods: We conducted a prospective observational cohort study to investigate in patients with COVID-19. From 9 February 4 April 2020, total 99 (31 critically ill 20 severely ill) confirmed were included study. Dynamic alterations profiles recorded...
Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift prognosis in AMI remain unclear. This study sought to investigate impact on reperfusion injury, a major determinant clinical outcomes AMI. Study patient data were obtained from database EARLY-MYO-CMR (Early Assessment Myocardial Tissue Characteristics by CMR STEMI) registry, which was prospective, multicenter registry patients ST-segment elevation...
Background Left atrial (LA) dysfunction is associated with morbidity and mortality. To the knowledge of authors, relationship LA strain to long-term prognosis in participants ST-segment elevation myocardial infarction (STEMI) unknown. Purpose evaluate as a outcome predictor STEMI prospective, multicenter cardiac MRI cohort. Materials Methods Participants who underwent primary percutaneous coronary intervention from 10 sites (EARLY-MYO-CMR registry, clinical trial number NCT03768453) were...
Coronavirus disease 2019 (COVID-19) broke out in December 2019. Due its high morbility and mortality, it is necessary to summarize the clinical characteristics of COVID-19 patients provide more theoretical basis for future treatment. In current study, we conducted a retrospective analysis explored risk factors severity illness. A total 101 hospitalized Leishenshan Hospital (Wuhan, China) was classified into three sub-types: moderate (n = 47), severe 36), critical 18); their data were...
CD147, also known as EMMPRIN or basigin, is a transmembrane glycoprotein receptor that activates matrix metalloproteinases and promotes inflammation. CD147 function regulated by posttranslational modifications of which glycosylation has attracted the most attention. In this study, we demonstrated glycosylated was dominant form in heart tissue, its levels were markedly elevated response to transverse aortic constriction (TAC). Adeno-associated virus 9-mediated, cardiac-specific overexpression...
Abstract Cuproptosis is a newly discovered copper ion‐dependent programmed cell death. Elesclomol (ES) Cu 2+ transporter that delivers into tumor cells, causing death at toxic doses. However, ES has short blood half‐life, limiting its accumulation in tumors. This study introduces Tussah silk fibroin nanoparticles (TSF@ES‐Cu NPs) to protect and . TSF, with stable structure, resists metabolism circulation. Targeting tumors natural RGD peptides TSF's unique secondary enhances drug enrichment...
To determine the association between low molecular weight heparin (LMWH) use and mortality in hospitalized COVID-19 patients. We conducted a retrospective study of patients consecutively enrolled from two major academic hospitals exclusively for Wuhan, China, January 26, 2020, to March 2020. The primary outcome was adjusted in-hospital LMWH group compared with non-LMWH using propensity score. Overall, 525 median age 64 years (IQR 19), 49.33% men. Among these, 120 (22.86%) were treated LMWH....
The prognostic value of left ventricular segmental strain (SS) in ST-elevation myocardial infarction (STEMI) remains unclear.
Summary. The prevalence of inhibitors in Chinese haemophiliacs has not yet been reported. aim this study was to identify the factor VIII (FVIII) among who are treated only with plasma‐derived FVIII (pdFVIII), cryoprecipitate or fresh frozen plasma (FFP), and tried explore relationship between generation particular deficiency genotypes. Clinical information blood samples 1435 patients haemophilia A (HA) were collected by six centres China. Nijmegen modification Bethesda assay used detect...
Left ventricular thrombus (LVT), a common complication of acute ST-segment elevation myocardial infarction (STEMI), is associated with increased risk systemic embolism and high mortality. Current STEMI guidelines recommend adding anticoagulant therapy to dual antiplatelet (DAPT) if early-formulated LVT were detected, for which vitamin K antagonist (VKA) the standard agent. The role non-VKA oral anticoagulants (NOACs) in this scenario uncertain.The EARLY-MYO-LVT study will be prospective,...
Background and Objective Extracellular matrix metalloproteinase inducer (EMMPRIN) is an important pro-inflammatory protein involved in the cellular functions of monocytes/macrophages. We have hypothesized that high-level heterogeneousness glycosylation EMMPRIN may functional relevance to its biological effects affect inflammatory activity Methods The patterns expressed by monocytes/macrophages (THP-1 cells) response different extracellular stimuli were observed, structures forms identified....
This study evaluated quantitative flow ratio (QFR) to predict microvascular dysfunction (MVD) in patients with ST-segment elevation myocardial infarction (STEMI).QFR is a novel approach for the rapid computation of fractional reserve based on three-dimensional coronary angiography. We hypothesized that QFR could be used MVD after STEMI.Indexes such as contrast-flow (cQFR), fixed-flow (fQFR), and hyperemic velocity (HFV) were calculated 130 STEMI culprit lesion ≥50% diameter stenosis TIMI...
ABSTRACT BACKGROUND Increasing attention has been paid to cardiac involvement in patients with coronavirus disease 2019 (COVID-19). Yet, scarce information is available regarding the morphological and functional features of impairments these patients. METHODS We conducted a prospective serial echocardiographic study investigate structural changes among COVID-19 admitted intensive care unit (ICU). From January 21 April 8, 2020, total 51 ICU (31 critically ill 20 severely ill) confirmed were...
Background Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide places significant financial burden on our society. Purpose To determine the feasibility cardiac intravoxel incoherent motion (IVIM) in consecutive evaluation perfusion patients postpercutaneous coronary intervention (PCI) to investigate dynamic biological phenomena after AMI. Study Type Prospective observational study. Population Twenty ST‐segment elevation (STEMI) reperfusion therapy 12...