A5062875840- Cardiac Fibrosis and Remodeling
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Signaling Pathways in Disease
- Advanced Glycation End Products research
- Congenital heart defects research
- Heavy Metal Exposure and Toxicity
- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Natural Antidiabetic Agents Studies
- Gout, Hyperuricemia, Uric Acid
- Diabetes Management and Research
- Reconstructive Surgery and Microvascular Techniques
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Acute Myocardial Infarction Research
- Ubiquitin and proteasome pathways
- Trace Elements in Health
- Peptidase Inhibition and Analysis
- Surgical Sutures and Adhesives
- Neutropenia and Cancer Infections
- Nuclear Receptors and Signaling
- Facial Nerve Paralysis Treatment and Research
- Extracellular vesicles in disease
Jiangsu Province Hospital
2019-2025
Nanjing Medical University
2019-2025
Nanjing Drum Tower Hospital
2024
Shanghai Jiao Tong University
2009-2021
Renji Hospital
2020-2021
Guiyang Medical University
2021
Ruijin Hospital
2012-2017
University of Jinan
2016
Shandong First Medical University
2016
Shandong Tumor Hospital
2016
The transplantation of mesenchymal stem cells (MSCs) is considered to be a promising treatment for ischemic heart disease; however, the therapeutic effects and underlying mechanisms action require further evaluation. Mitochondrial dysfunction key event in simulated ischemia/reperfusion (SI/R) injury. purpose present study was investigate mechanism mitochondrial transfer, which may involved antiapoptotic co-culture with MSCs. An vitro model used study. apoptotic indexes were significantly...
Islet replacement therapy is limited by shortage of donor islet cells. Usage cells derived from porcine pancreatic stem (PSCs) currently viewed as the most promising alternative for human transplantation. However, PSCs are rare and have a finite proliferative lifespan. In this study, we isolated established an immortalized mesenchymal cell (MSC) line foetal pancreas, transfecting telomerase reverse transcriptase (hTERT) called these (iPMSCs). The iPMSCs been cultured more than 80 passages...
Abstract Long noncoding RNAs (lncRNAs) have been increasingly considered to play an important role in the pathological process of various cardiovascular diseases, which often bind proximal promoters protein‐coding gene regulate protein expression. However, functions and mechanisms lncRNAs cardiomyocytes not fully elucidated. High‐throughput RNA sequencing was performed identify differently expressed messenger (mRNAs) between acute myocardial infarction (AMI) rats healthy controls. One novel...
Abstract Pyroptosis is associated with various cardiovascular diseases. Increasing evidence suggests that long noncoding RNAs (lncRNAs) have been implicated in gene regulation, but how lncRNAs participate the regulation of pyroptosis heart remains largely unknown. In this study, we aimed to explore antipyroptotic effects lncRNA FGF9‐associated factor (FAF) acute myocardial infarction (AMI). The expression patterns FAF, miR‐185‐5p and P21 activated kinase 2 (PAK2) were detected...
Neonatal mice achieve complete cardiac repair through endogenous myocardial regeneration after apical resection (AR), but this capacity is rapidly lost 7 days birth. As an upstream inhibitor of cyclin-dependent kinase 4/6- (CDK4/6-) mediated cell cycle activity, p16INK4a widely involved in regulating tumor and senescence. Given that had a significant negative regulation on proliferation, targeting cardiomyocytes (CMs) to inhibit seems be promising attempt at therapy. The expression was...
The regenerative capacity of the adult mammalian hearts is limited. Numerous studies have explored mechanisms cardiomyocyte cell-cycle withdrawal. This translational study evaluated effects and underlying mechanism rhCHK1 (recombinant human checkpoint kinase 1) on survival proliferation myocardial repair after ischemia/reperfusion injury in swine.
This study evaluated quantitative flow ratio (QFR) to predict microvascular dysfunction (MVD) in patients with ST-segment elevation myocardial infarction (STEMI).QFR is a novel approach for the rapid computation of fractional reserve based on three-dimensional coronary angiography. We hypothesized that QFR could be used MVD after STEMI.Indexes such as contrast-flow (cQFR), fixed-flow (fQFR), and hyperemic velocity (HFV) were calculated 130 STEMI culprit lesion ≥50% diameter stenosis TIMI...
Background The neonatal heart maintains its entire regeneration capacity within days after birth. Using quantitative phosphoproteomics technology, we identified that SGK3 (serine/threonine‐protein kinase 3) in the is highly expressed and activated myocardial infarction. This study aimed to uncover function related mechanisms of on cardiomyocyte proliferation cardiac repair apical resection or ischemia/reperfusion injury. Methods Results effect oxygen glucose deprivation/reoxygenation–...
To investigate feasibility and effectiveness of the establishing porcine ischemia-reperfusion models by ligating left anterior descending (LAD) coronary artery, we first randomly divided 16 male Bama pigs into a sham group model group. After anesthesia, separated arteries veins passed LAD artery through median thoracic incision to be below beginning its diagonal branch. Then, loosened released ligation line after five minutes pre-occlusion. Finally, ligated <i>in situ</i> two later ligature...
To investigate the relationship of glycation gap (GGap) with all-cause and cardiovascular (CV) mortality in US adults.This was a retrospective cohort study comprising 12 909 individual participant data from National Health Nutrition Examination Survey 1999 to 2004 their through 31 December 2019. Weighted Cox proportional hazards regression models restricted cubic splines were used associations between GGap mortality.During median follow-up 16.8 years, 3528 deaths occurred, including 1140 CV...
Background: Recent studies have suggested that soluble suppression of tumorigenicity-2 (sST2), an inflammation-related protein receptor, is associated with atherosclerotic diseases. This study aimed to investigate the potential predictive value sST2 on plaque vulnerability by assessing whether elevated serum levels are vulnerable features in patients non-ST-elevation acute coronary syndrome (ACS). Methods: A total 120 ACS (167 lesions) were prospectively enrolled and evaluated standard...
p-cresyl sulfate (PCS) is a protein-bound uremic toxin retained in the blood of patients with chronic kidney disease (CKD) As atherosclerosis primary cardiovascular complication for CKD, aim present study was to investigate mechanisms underlying aggravation by PCS. In addition, effect atorvastatin assessed reversing effects PCS revealed promote initiation and progression atherosclerosis. Following treatment atorvastatin, apolipoprotein E knockout mice demonstrated reduction PCS‑induced...
Psoriasis is a chronic inflammatory disease that involves complex pathogenic interactions between the innate and adaptive immune systems, affecting approximately 2% of population. In patients with psoriasis, incidence several important diseases reportedly higher than observed in general Among them, cardiovascular (CVDs) are most common cause morbidity mortality psoriasis. Hence, effective safe treatments critical lowering risk this patient group. Systemic treatment psoriasis major adverse...
Objective To evaluate whether glycation of high-density lipoprotein (HDL) increases cardiovascular risk in patients with type 2 diabetes mellitus by altering its anti-atherogenic property. Data sources cited this review were obtained mainly from Pubmed and Medline English 2000 to 2013, keywords “glycation”, “HDL”, “atherosclerosis”. Study selection Articles regarding HDL role atherogenesis both humans experimental animal models identified, retrieved reviewed. Results Glycation alters the...
The mammalian heart possesses entire regeneration capacity after birth, which is lost in adulthood. role of the kinase network myocardial remains largely elusive. SGK3 (threonine-protein 3) a functional we identified previously with to promote cardiomyocyte proliferation and cardiac repair infarction. However, upstream signals regulating are still unknown. Based on quantitative phosphoproteomics data pulldown assay, cyclin-dependent 9 (CDK9) as novel therapeutic target therapy. direct...