A5039554720- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Plant Pathogens and Fungal Diseases
- Takotsubo Cardiomyopathy and Associated Phenomena
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Vaccine Coverage and Hesitancy
- Cardiac Fibrosis and Remodeling
- Skin and Cellular Biology Research
- Intracranial Aneurysms: Treatment and Complications
- Extracellular vesicles in disease
- Animal Behavior and Welfare Studies
- Mechanical Circulatory Support Devices
- Ubiquitin and proteasome pathways
- Human-Animal Interaction Studies
- Cardiac Structural Anomalies and Repair
- Plant Gene Expression Analysis
- Sleep and Work-Related Fatigue
- Advanced Nanomaterials in Catalysis
- Cardiovascular Effects of Exercise
- Cellular Mechanics and Interactions
- Neurosurgical Procedures and Complications
- Circular RNAs in diseases
- Insect-Plant Interactions and Control
- Advanced biosensing and bioanalysis techniques
Heidelberg University
2022-2025
University Hospital Heidelberg
2022-2025
Jiangsu Province Hospital
2017-2023
Nanjing Medical University
2012-2023
Wuxi People's Hospital
2013
Southeast University
2010
Nanjing Agricultural University
2010
miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages a uremic heart. The released exosomal fusion with the plasma membrane leads to release cytosol translational repression forkhead transcription factors O class (FoxO3a) cardiomyocytes. Finally, macrophage-derived miR-155-containing promoted cardiomyocyte pyroptosis cardiomyopathy changes (cardiac hypertrophy fibrosis) by directly targeting FoxO3a mice.
Abstract Tight control of cell fate choices is crucial for normal development. Here we show that lamin A/C plays a key role in chromatin organization embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper during cardiogenesis. We report changes compaction localization cardiac genes Lmna −/− ESCs resulting precocious activation transcriptional program promoting cardiomyocyte versus endothelial fate. This accompanied by premature differentiation, cycle withdrawal...
Congestive heart failure (CHF) is a common cardiovascular disease that often accompanied by ventricular arrhythmias. The decrease of the slow component delayed rectifier potassium current (IKs) in CHF leads to action potential (AP) prolongation, and IKs an important contributor development However, molecular mechanisms underlying arrhythmias are still unknown.Kcna2 Kcna2 antisense RNA (Kcna2 AS) transcript expression was measured rat cardiac tissues using quantitative real-time reverse...
Abstract Background Takotsubo cardiomyopathy (TTC) is marked by an acute, transient, and reversible left ventricular systolic dysfunction triggered stress, with endothelial being one of its pathophysiological mechanisms. However, the precise molecular mechanism underlying interaction between cells cardiomyocytes during TTC remains unclear. This study reveals that exosomal miRNAs derived from exposed to catecholamine contribute ion channel in setting TTC. Methods Human-induced pluripotent...
Epigallocatechin-3-gallate (EGCG), a major catechin found in green tea, has been shown to prevent cardiovascular diseases. Previously, Matrix metalloproteinase-9 (MMP-9), monocyte chemotactic protein-1 (MCP-1) and toll-like receptor 4 (TLR4) were confirmed play an important role atherosclerosis plaque instability. Both TLR4 its negative regulator, Toll-interacting protein (Tollip), could be mediated by EGCG. The present study aimed examine the effect of physiological concentration EGCG (1...
Abstract Long noncoding RNAs (lncRNAs) have been increasingly considered to play an important role in the pathological process of various cardiovascular diseases, which often bind proximal promoters protein‐coding gene regulate protein expression. However, functions and mechanisms lncRNAs cardiomyocytes not fully elucidated. High‐throughput RNA sequencing was performed identify differently expressed messenger (mRNAs) between acute myocardial infarction (AMI) rats healthy controls. One novel...
Sustained cardiac hypertrophy (CH) contributes to many heart diseases. Long noncoding RNAs (lncRNAs) collectively play critical roles in cardiovascular diseases (CVDs). However, the of lncRNA H19 CH are still unclear. A model was constructed utilizing isoproterenol (ISO). We demonstrated could participate regulating ISO-induced development both vivo and vitro. The online databases DIANA TargetScan were used predict targets MicroRNA-145-3p (miR-145-3p), respectively. Luciferase reporter assay...
A number of studies have suggested the benefits pet ownership to human health, including cardiovascular disease (CVD). However, there are few findings regarding and coronary artery (CAD). The objective this study is investigate association between CAD in a Chinese population. From October 2015 May 2016, survey consisting 561 consecutive patients was done Nanjing, China. Based on results arteriography for first time, participants were divided into 2 groups (non-CAD groups). Pet information...
Background: Epigallocatechin-3-gallate (EGCG), which is the principal component of green tea, has been shown to prevent atherosclerosis. However, effect EGCG on atherosclerotic plaque stability remains unknown. Aim: This study aimed assess whether can enhance and investigate underlying mechanisms. Methods: Apolipoprotein E-deficient mice fed a high-fat diet were injected intraperitoneally with (10 mg/kg) for 16 weeks. Cross sections brachiocephalic arteries stained haematoxylin eosin...
Abstract Objectives We aimed to assess the effect of selective intracoronary hypothermia on outcomes in patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Background Intracoronary hypothermia, feasibility and safety which has been validated humans, induced by trans‐coronary infusion saline at different temperatures can reduce infarct size (IS) prior reperfusion animal models STEMI. Methods Sixty STEMI presenting...
To explore the association of working hours and occupational physical activity (OPA) with occurrence coronary heart disease (CHD) in a Chinese population.A total 595 participants (354 241 patients without CHD, respectively) aged between 24 65 were enrolled our study, which was conducted at First Affiliated Hospital Nanjing Medical University December 2015 October 2016. Participant characteristics collected from face-to-face questionnaires, logistic regression analysis to examine OPA...
Punctate palmoplantar keratoderma (PPPK, OMIM 148600) is a rare hereditary disorder characterized by multiple punctate keratoses on the palms and soles. Recently, mutations in genes α- γ-adaptin-binding protein p34 (AAGAB) collagen, type XIV, α1 (COL14A1) have been reported to cause PPPK.To identify AAGAB COL14A1 three Chinese families with PPPK.Genomic DNA of family members 100 healthy individuals was isolated. Direct sequencing all polymerase chain reaction products whole coding regions...
We investigated 2 Chinese families with dyschromatosis symmetrica hereditaria (DSH) and to search for mutations in the ADAR1 gene these pedigrees.We performed a mutation analysis of DSH reviewed all published articles regarding reported since 2003 by using PubMed.By direct sequencing, 2-nucleotide AG deletion, 2099-2100delAG, was found family 1, C→T identified at nucleotide 1420 that changed codon 474 from arginine translational termination 2. Two different pathogenic were identified, is,...