A5035818972- Tea Polyphenols and Effects
- Atherosclerosis and Cardiovascular Diseases
- Ginkgo biloba and Cashew Applications
- Phytochemicals and Antioxidant Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Nutritional Studies and Diet
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Physical Activity and Health
- Acute Kidney Injury Research
- Cardiac Ischemia and Reperfusion
- Heart Failure Treatment and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Imaging and Diagnostics
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2015-2025
Abstract Background Hyperlipidemia plays a crucial role in the development and progression of coronary artery disease (CAD). Recent studies have identified that microRNAs (miRNAs) are important regulators lipid metabolism, but little is known about circulating levels lipometabolism-related miRNAs their relationship with presence CAD patients hyperlipidemia. Methods In present study, we enrolled total 255 hyperlipidemia or without 100 controls normal blood lipids. The plasma four miRNAs,...
Uremic cardiomyopathy and muscle atrophy are associated with insulin resistance contribute to chronic kidney disease (CKD)-induced morbidity mortality. We hypothesized that restoration of miR-26a levels would enhance exosome-mediated microRNA transfer improve wasting occur in CKD. Methods: Using next generation sequencing qPCR, we found CKD mice had a decreased level heart skeletal muscle. engineered an exosome vector contained Lamp2b, exosomal membrane protein gene fused muscle-specific...
miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages a uremic heart. The released exosomal fusion with the plasma membrane leads to release cytosol translational repression forkhead transcription factors O class (FoxO3a) cardiomyocytes. Finally, macrophage-derived miR-155-containing promoted cardiomyocyte pyroptosis cardiomyopathy changes (cardiac hypertrophy fibrosis) by directly targeting FoxO3a mice.
Congestive heart failure (CHF) is a common cardiovascular disease that often accompanied by ventricular arrhythmias. The decrease of the slow component delayed rectifier potassium current (IKs) in CHF leads to action potential (AP) prolongation, and IKs an important contributor development However, molecular mechanisms underlying arrhythmias are still unknown.Kcna2 Kcna2 antisense RNA (Kcna2 AS) transcript expression was measured rat cardiac tissues using quantitative real-time reverse...
Abstract Ischemia‒reperfusion (I/R) is a common complication in the clinical treatment of acute myocardial infarction (MI), which cardiomyocytes play pivotal role recovery cardiac function after reperfusion injury. The expression numerous circular ribonucleic acids (circRNAs) disrupted I/R‐induced damage, but potential circRNAs I/R damage has not been fully elucidated. purpose present study was to clarify biological action and molecular mechanism circRNA 002166 (also termed circCL2L13)...
ABSTRACT Myocardial infarction (MI) often results in significant loss of cardiomyocytes (CMs), contributing to adverse ventricular remodelling and heart failure. Therefore, promoting CM survival during the acute stage MI is crucial. This study aimed investigate potential role GPX3 cardiac repair following MI. First, plasma levels were measured patients with (AMI), myocardial expression was assessed a mouse model. Furthermore, effects on investigated through CM‐specific overexpression or...
Musk has been traditionally used in East Asia to alleviate the symptoms of angina pectoris. However, it remains unclear as whether muscone, main active ingredient musk, any beneficial effects on persistent myocardial ischemia vivo. The aim present study was investigate muscone can improve cardiac function and attenuate remodeling following infarction (MI) mice. Mice were subjected permanent ligation left anterior descending coronary artery induce MI, then randomly treated with (2 mg/kg/day)...
Epigallocatechin-3-gallate (EGCG), a major catechin found in green tea, has been shown to prevent cardiovascular diseases. Previously, Matrix metalloproteinase-9 (MMP-9), monocyte chemotactic protein-1 (MCP-1) and toll-like receptor 4 (TLR4) were confirmed play an important role atherosclerosis plaque instability. Both TLR4 its negative regulator, Toll-interacting protein (Tollip), could be mediated by EGCG. The present study aimed examine the effect of physiological concentration EGCG (1...
Objective The relationship between admission serum calcium levels and in-hospital mortality in patients with acute ST-segment elevation myocardial infarction (STEMI) has not been well definitively explored. objective was to assess the predictive value of on STEMI patients. Methods From 2003 2010, 1431 consecutive admitted First Affiliated Hospital Nanjing Medical University were enrolled present study. Patients stratified according quartiles from blood samples collected emergency room after...
Aims: Epigallocatechin-3-gallate (EGCG), a major catechin found in green tea, displays variety of pharmacological properties and recently received attention as prospective dietary intervention cardiovascular diseases (CVD). This study was conducted to test the hypothesis that EGCG able inhibit tumor necrosis factor-a (TNF-a)-induced production monocyte chemoattractant protein-1 (MCP-1) human umbilical vein endothelial cells (HUVECs) investigated underlying molecular mechanisms. Methods: The...
Background/Aims: It is well documented that overexpression of EMMPRIN (extracellular matrix metalloproteinase inducer) and MMPs (matrix metalloproteinases) by monocytes/macrophages plays an important role in atherosclerotic plaque rupture. Green tea polyphenol epigallocatechin-3-gallate (EGCG) has a variety pharmacological properties exerts cardiovascular protective effects. Recently, the 67-kD laminin receptor (67LR) been identified as cell surface EGCG. The aim present study was to...
Correlation of triglyceride (TG)-to-high density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) and the survival gastric cancer (GC) remain unclear. The purpose this study was to explore precise effect preoperative TG/HDL-C on clinical outcomes in GC patients. Patients with were enrolled from 2006 2014. A total 957 individuals a single center divided into prospective training retrospective test cohorts. optimal cutoff value determined using X-tile software separate cohort low high groups...
Sepsis-induced myocardial dysfunction (SIMD) has become one of the most lethal complications sepsis, while treatment was limited by a shortage pertinent drugs. Epigallocatechin-3-gallate (EGCG) is highest content active substances in green tea, and its application cardiovascular diseases broad prospects. This study conducted to test hypothesis that EGCG able inhibit lipopolysaccharide (LPS) induced investigate underlying molecular mechanisms. The cardiac systolic function assessed...
A number of studies have suggested the benefits pet ownership to human health, including cardiovascular disease (CVD). However, there are few findings regarding and coronary artery (CAD). The objective this study is investigate association between CAD in a Chinese population. From October 2015 May 2016, survey consisting 561 consecutive patients was done Nanjing, China. Based on results arteriography for first time, participants were divided into 2 groups (non-CAD groups). Pet information...