A5101475507- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Acute Kidney Injury Research
- Vitamin C and Antioxidants Research
- Genetic Syndromes and Imprinting
- Cancer and Skin Lesions
- Gut microbiota and health
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Ureteral procedures and complications
- Genetic factors in colorectal cancer
- Birth, Development, and Health
- Lung Cancer Treatments and Mutations
- Biomedical Research and Pathophysiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Kidney Disease and Diabetes
- Supramolecular Self-Assembly in Materials
Weifang Medical University
2014-2024
First Hospital of China Medical University
2018-2024
China Medical University
2018-2024
National Health and Family Planning Commission
2023
Central South University
2019-2023
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Jinan Central Hospital
2023
Shandong First Medical University
2023
Nanjing Medical University
2013-2022
Recent studies in animal models and humans show that long non-coding RNAs (lncRNAs) are involved the development of atherosclerosis, which contributes to pathological foundation coronary artery disease (CAD). LncRNAs plasma serum have been considered as promising novel biomarkers for diagnosis prognosis cardiovascular diseases, especially CAD. We here measured circulating levels 8 individual lncRNAs known be relevant atherosclerosis samples from 300 patients with CAD 180 control subjects by...
Abstract Pancreatic adenocarcinoma (PAAD), one of the most prevailing malignant tumors in digestive system, is identified as main culprits cancer-associated mortality. Despite long intergenic non-protein coding RNA 1232 (LINC01232) found to be upregulated TCGA PAAD tissues and associated with poor prognosis, potential LINC01232 progression still needs more explorations. In this study, was chosen research object cellular processes. Functionally, loss-of function assays were carried out...
Congestive heart failure (CHF) is a common cardiovascular disease that often accompanied by ventricular arrhythmias. The decrease of the slow component delayed rectifier potassium current (IKs) in CHF leads to action potential (AP) prolongation, and IKs an important contributor development However, molecular mechanisms underlying arrhythmias are still unknown.Kcna2 Kcna2 antisense RNA (Kcna2 AS) transcript expression was measured rat cardiac tissues using quantitative real-time reverse...
Long non-coding RNA (lncRNA) is important in many diseases. Some studies have shown that lncRNA affects the pathogenesis of systemic inflammation asthma. regulates gene transcription, protein expression, and epigenetic regulation. However, lncRNAs associated with different airway phenotypes, such as eosinophilic (Eos) neutrophilic (Neu) asthma not been identified. The goal this study was to determine differences circulating signatures Eos Neu samples. Using RNA-sequencing (RNA-seq),...
Abstract It is commonly assumed that gastrointestinal cancer the most common form of across globe and leading contributor to cancer-related death. The intricate mechanisms underlying growth GI cancers have been identified. worth mentioning both non-coding RNAs (ncRNAs) certain types RNA, such as circular (circRNAs), long (lncRNAs), microRNAs (miRNAs), can considerable impact on development (GI) cancers. As a tumour suppressor, in group short regulatory miR-34a. miR-34a silences multiple...
Preeclampsia (PE) is one of the leading causes maternal and perinatal mortality morbidity. One main hallmarks observed in PE impaired inflammation state. In current study, we found that miR-125b was deregulated placental tissues plasma derived from patients, which suggest a potential association between this miRNA pathogenesis PE. Overexpression significantly reduced SGPL1 expression, luciferase assays confirmed direct target miR-125b. We also enhanced IL-8 production by directly targeting...
Long noncoding RNA (lncRNA) plays roles in many diseases including asthma. Several lncRNAs function the early differentiation of T-helper cells. lncRNA controls gene transcription, protein expression, and epigenetic regulation. Of 4 asthma phenotypes, eosinophilic (EA) is most common. However, associated with have yet to be identified. We designed a study identify circulating signature EA samples. tested whether significant differences expression were observed between blood samples from...
Resistance to radiotherapy is the main reason causing treatment failure in locally advanced rectal cancer. MicroRNAs (miRNAs) have been well demonstrated regulate cancer development and progression. However, how miRNAs resistance colorectal remains unknown. Herein, we established two human cell lines resistant radiotherapy, named HCT116-R RKO-R, using strategy of fractionated irradiation. The radioresistant phenotypical changes were validated by viability assay, colony formation assay...
Sustained cardiac hypertrophy (CH) contributes to many heart diseases. Long noncoding RNAs (lncRNAs) collectively play critical roles in cardiovascular diseases (CVDs). However, the of lncRNA H19 CH are still unclear. A model was constructed utilizing isoproterenol (ISO). We demonstrated could participate regulating ISO-induced development both vivo and vitro. The online databases DIANA TargetScan were used predict targets MicroRNA-145-3p (miR-145-3p), respectively. Luciferase reporter assay...
Background/Aims: Na+/H+ exchanger 1 (NHE1) is an important regulator of intracellular pH (pHi). High pHi required for cell proliferation and differentiation. Our previous study has proven that the mesenchymal stem cells higher than normal differentiated similar to tumor cells. NHE1 highly expressed in both Targeted inhibition could induce differentiation K562 leukemia In present paper we explored whether Methods: MSCs were obtained from human umbilical cord surface phenotype functional...
Objectives The prognosis of invasive micropapillary carcinoma (IMPC) the breast is determined by many clinicopathological factors. This study aims to identify prognostic factors and develop reliable nomogram predict overall survival (OS) in patients with IMPC. Design Log-rank test Cox proportional hazards analysis were used variables construct a based on training cohort. C-index calibration curves performed evaluate performance model cohort validation cohorts. Setting We collected patient...
Despite significant advances in the treatment of coronary artery disease, prevalence ischemic heart failure is still increasing rapidly. Long noncoding RNAs are a novel class gene regulators and may contribute to disease cause. The aim present study was investigate expression profiles long their potential functional roles failure.We applied well-established rat model performed RNA microarray experiments on left ventricular tissue rats with under sham control. Differentially expressed mRNAs...
miR-944 belongs to the MicroRNAs family, as shown in our previous study, and is essential colorectal cancer (CRC) progression. It negatively associated with invasion depth lymph node status. Epithelial-mesenchymal transition (EMT) tumor metastasis. However, relationship between EMT CRC unknown should be further investigated.Epithelial-mesenchymal progression cell lines was detected Cell morphology Western blotting. migration were examined using Transwell assays. Transcriptome clinical data...
Cholangiocarcinoma (CCA) is the second most common type of primary malignancy liver. Certain long non‑coding RNAs (lncRNAs) have been demonstrated to key roles in tumor pathogenesis by binding microRNAs (miRNAs). However, competing endogenous RNA (ceRNA) network CCA remains be fully determined. In present study, expression profiles for were downloaded from The Cancer Genome Atlas and further analyzed. A total 318 differentially expressed (DE) lncRNAs, 87 DE miRNAs 3,851 mRNAs identified 36...
Hydronephrosis resulting from unilateral ureteral obstruction (UUO) is a common cause of renal injury, often progressing to late-stage fibrosis or even potential failure. Renal injury and repair processes are accompanied by changes in cellular senescence phenotypes. However, the mechanism poorly understood. The purpose this study clarify phenotype at different time points disease caused UUO further investigate whether eliminating senescent cells using anti-senescence drug ABT263 could...
CCAAT/enhancer binding protein homologous (CHOP) expression increases when Na(+)-H(+) exchanger 1 (NHE1) is inhibited. Endoplasmic reticulum (ER) stress has been shown to trigger tumor cell death through CHOP. We therefore hypothesized that NHE1 activity correlates with ER and confers pharmaceutical potential inhibitor as an anti-tumor agent. The present study showed treatment the cariporide led stress-induced up-regulation of receptor 5 (DR5) which mediated by CHOP at transcriptional level....