A5028227498- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Brain Metastases and Treatment
- Cancer, Lipids, and Metabolism
- Carbon and Quantum Dots Applications
- Circular RNAs in diseases
- Advanced Nanomaterials in Catalysis
- Herpesvirus Infections and Treatments
Central South University
2021-2024
Hunan Cancer Hospital
2021-2024
Ministry of Health
2024
National Health and Family Planning Commission
2023
CircRNAs have garnered significant interest in recent years due to their regulation human tumorigenesis, yet, the function of most glioma-related circRNAs remains unclear.In this study, using RNA-Seq, we screened differentially regulated glioma, comparison non-tumor brain tissue.Loss-and gain-of-function strategies were used assess effect circCDK14 on tumor progression both vitro and vivo.Luciferase reporter, RNA pull-down fluorescence situ hybridization assays carried out validate...
Glioblastoma (GBM) is a fatal primary brain malignancy in adults. Previous studies have shown that cytomegalovirus (CMV) risk factor for tumorigenesis and aggressiveness glioblastoma. However, little known about how CMV infection affects immune cells the tumor microenvironment of GBM. Furthermore, there has been almost no engineered T-cell receptor (TCR)-T targeting GBM research to date. We evaluated status patients with GBM's tissue by electron microscopy, immunofluorescence, droplet...
Abstract The blood–brain barrier is often altered in glioblastoma (GBM) creating a blood–brain–tumor (BBTB) composed of pericytes. BBTB affects chemotherapy efficacy. However, the expression signatures BBTB‐associated pericytes remain unclear. We aimed to identify single‐cell RNA sequencing data GBM using pericyte markers, normal brain signature, and functional enrichment. identified parathyroid hormone receptor‐1 (PTH1R) as potential marker associated with function. These interact other...
Abstract Crosstalk between tumors and the nervous system has emerged as a significant hallmark of human cancer. In central system, neurons closely interact with tumor cells, promoting proliferation glioma neuroblastoma. Additionally, peripheral plays crucial role in reshaping microenvironment, modulating angiogenesis, regulating immune cell function, while also directly tumorigenesis metastasis. Current research elucidated some specific neural signaling mechanisms involved this crosstalk,...
NRF2 signaling is a crucial antioxidant defense mechanism against ferroptosis in tumors, and targeting essential for tumor therapy. However, the effectiveness of inhibitors remains unexplored. The active ingredients traditional Chinese medicine serve as important sources inhibitors. In this study, we established an intracranial glioblastoma (GBM) orthotopic model observed effects procyanidin B1 on growth ferroptosis. Using protein-small-molecule docking, z-stack assay laser confocal imaging,...
Glioblastoma is a fatal primary brain cancer lacking effective therapeutic drugs. The presence of the blood-brain barrier (BBB) severely hinders delivery drugs to brain. In recent years, nanoparticles, especially carbon dots (CDs), are promising drug strategy for CNS diseases. Here, we synthesized novel dots（MGA-CDs）for glioblastoma treatment by hydrothermal method using metformin and gallic acid as precursor. MGA-CDs shows dominant BBB permeability sensitive anti-tumor activity. addition,...
Abstract Background: Pericytes compose blood–brain barrier (BBB) and may affects the blood-brain tumor function (BBTB) in glioblastoma (GBM), which eventually affect chemotherapy efficiency progression of disease. However, expression signatures detailed effect these pericyte are still unclear. We aimed to identify pericytes affecting BBTB GBM, explore their clinical underlying functions. Methods: GBM were identified from single-cell RNA sequencing (scRNA-seq) da ta nine samples by hallmarks...