A5101842114- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- Oral health in cancer treatment
- Fibroblast Growth Factor Research
- Proteoglycans and glycosaminoglycans research
- Clostridium difficile and Clostridium perfringens research
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Microbial Inactivation Methods
- Spectroscopy and Chemometric Analyses
- Salivary Gland Disorders and Functions
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Cultural Heritage Materials Analysis
- Helicobacter pylori-related gastroenterology studies
- Ultrasound and Hyperthermia Applications
- Water Quality Monitoring and Analysis
Third Xiangya Hospital
2023-2024
Central South University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
Sun Yat-sen University
2022
Xi'an Jiaotong University
2020
Wuhan University
2019
Renmin Hospital of Wuhan University
2019
Guangzhou University of Chinese Medicine
2018
Shanghai Jiao Tong University
2017
Huadong Hospital
2017
Background: HLJDD (Huang-Lian-Jie-Du-Decoction), a prescription of traditional Chinese medicine, has been clinically used to treat diabetes for thousands years and its mechanism was reported be related gut microbiota. However, no study explored the effect on microbiota in type 2 mellitus (T2DM) yet. Therefore, this study, we investigated modulation induced by treatment T2DM order unveil underlying mechanism. Methods: A combination high-fat diet (HFD) streptozotocin (STZ) induce rats....
Background Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death 1 (PD-1)/programmed ligand (PD-L1) shows promising clinical benefits. However, the relatively low response rate highlights need to develop an alternative strategy target PD-1/PD-L1 immune checkpoint. Our study focuses on role and mechanism of annexin A1 (ANXA1)-derived peptide A11 degrading PD-L1 effect tumor evasion in multiple cancers. Methods Binding was identified by biotin pull-down coupled with mass...
In the era of precision medicine, chemotherapy is still considered cornerstone treatment for lung cancer patients without gene mutations. How to reduce toxicity and increase efficiency worth exploring. This study aimed investigate curative effects safety hyperthermia combined with (HCT) advanced non-small cell (NSCLC), especially those malignant pleural effusion.We retrospectively evaluated medical records 93 NSCLC (stage IIIB-IV) from March 2011 January 2014. The were divided into HCT (CT)...
The microenvironment of postpartum mammary gland involution (PMI) has been linked to the increased risk breast cancer and poor outcome patients. Nevertheless mechanism underlying regulates remains largely unknown. MUC1, which is abnormally overexpressed in most cancer, physiologically expressed PMI. Using MUC1 cytoplasm domain (MUC1-CD) transgenic mice, we reveal that overexpression MUC1-CD epithelial cells increases M2 type macrophage infiltration By sustain activating p50, upregulates...
OBJECTIVE To assess the difference of genetic alteration patterns among different areas in same oral squamous cell carcinoma (OSCC). METHODS Studied loss heterozygosity (LOH) and microsatellite instability (MI) at chromosomal loci TP53 RPS6 on invasive tumor front (ITF), center/superficial part stroma cells by combining laser capture microdissection (LCM) PCR technique. RESULTS There existed a high frequency LOH MI chromosomes RPS6. The aberration was 23.5% (4/17) 43.8% (7/16), respectively....
Prostate cancer (PC) is the second most common diagnosed malignant disease.Long non-coding RNAs (lncRNAs), which account for approximately 98% of human genome, are becoming increasingly interesting with regard to various diseases and have great potential diagnosis prognostic monitoring PC.To identify a new marker metastatic PC, we enrolled total 144 patients including 57 87 localized PC patients, 148 healthy subjects.Patients were followed up routinely at 3-month intervals 5 years.The...
NRF2 signaling is a crucial antioxidant defense mechanism against ferroptosis in tumors, and targeting essential for tumor therapy. However, the effectiveness of inhibitors remains unexplored. The active ingredients traditional Chinese medicine serve as important sources inhibitors. In this study, we established an intracranial glioblastoma (GBM) orthotopic model observed effects procyanidin B1 on growth ferroptosis. Using protein-small-molecule docking, z-stack assay laser confocal imaging,...
Objective: Thyroid cancer (TC) therapy, which is routinely used at present, can improve patients’ survival rates. However, lymph node metastasis results in a higher degree of TC malignancy patients who experience recurrence and/or death. The elucidation new mechanisms help identify therapeutic targets. Midkine (MDK) expressed aberrantly various cancers. the regulatory MDK remain largely unknown. Hence, this study mainly explores effect and molecular function TC. Material Methods: gene...
The degree of polymerization (DP) is the most direct parameter to characterize aging condition oilpaper insulation. Recently, near infrared spectroscopy (NIRS) used evaluate DP oil-paper insulation for it a rapid and non-destructive detection compared with traditional viscometric method. However, real applications NIRS are constrained by poor generalization ability current prediction algorithms. This paper studies intelligent algorithms precisely predicting radial basis function (RBF) neural...
Objective To observe the distribution and enrichment of foreign muhidrug resmtance gene 1(mdr1)in bone marrow mononuclear cells peripheral blood in liver cancer mice with intensive chemotherapy.Methods The which transferred retrovirus-mediated mdr1 were transplanted into Balb/c cancer.The expression mdrl cells,peripheral chief organs detected by immunohistochernistry reverse transcriptase polymerase chain reaction(RT-PCR).And white counting P-glucoprotein tumors monitored.Results There was...
Abstract Genomic variation of FGFR has been intensively investigated in cancer for years, however, clinical trials on the basis mutation or amplification as a druggable target inhibitors have produced disappointing outcomes. Therefore, identification predictive biomarkers FGFR-targeted agents remained crucial issue. Expression profiles FGF and 8,111 patients with 24 types solid tumors 879 tumor cell lines along drug sensitivity data were obtained from public databases. Differential...