A5071212252- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Colorectal Cancer Surgical Treatments
- Antimicrobial Peptides and Activities
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Extracellular vesicles in disease
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- Metabolism and Genetic Disorders
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Ultrasound and Hyperthermia Applications
- Nanocluster Synthesis and Applications
- Peroxisome Proliferator-Activated Receptors
- Influenza Virus Research Studies
- Colorectal Cancer Screening and Detection
- Characterization and Applications of Magnetic Nanoparticles
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Long-Term Effects of COVID-19
Shanghai East Hospital
2016-2025
Hunan Cancer Hospital
2023-2025
Central South University
2023-2025
Shanghai Sixth People's Hospital
2016-2024
Shanghai Jiao Tong University
2015-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Ministry of Health
2024
Xiangya Hospital Central South University
2023
Weifang Medical University
2019-2022
Shanghai First People's Hospital
2017-2021
Abstract T cells require continual presence of extrinsic signals from their in vivo microenvironment to maintain viability. removed these and placed tissue culture atrophied died a caspase-independent manner. Atrophy was characterized by smaller cell sizes, delayed mitogenic responses, decreased glycolytic rate. Bcl-2 expression remained constant vitro despite ongoing death, indicating that endogenous is insufficient explain the life span size control lymphocytes cell-extrinsic provided may...
2D PEG-ylated MoS2/Bi2 S3 composite nanosheets are successfully constructed by introducing bismuth ions to react with the two extra S atoms in a (NH4)2 MoS4 molecule precursor for solvothermal synthesis of MoS2. The MBP can serve as promising platform computed tomography and photoacoustic-imaging-guided tumor diagnosis, well combined photothermal therapy sensitized radiotherapy.
MoS2 nanosheets and a doxorubicin (DOX)-containing poly (lactic-co-glycolic acid) (PLGA)/MoS2/DOX composite implant are successfully constructed based on the unique phase-changing behavior of PLGA/MoS2/DOX oleosol within tumors. The fast phase transformation can firmly restrict DOX tumors, integrated endow with high synergistic photothermal chemotherapeutic efficiency against As minimally or noninvasively therapeutic method, therapy (PTT) tumors induced by near-infrared (NIR) laser has...
Novel core–shell hollow mesoporous Prussian blue @ Mn-containing analogue ([email protected]) nanoparticles, designated as HMPB-Mn) an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used pH-responsive T1-weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m−1 s−1), and achieves the real-time monitoring of drug release. As service to our authors readers,...
Ischemic stroke is a devastating disease and one of the leading causes mortality worldwide. Overproduction reactive oxygen nitrogen species (RONS) following ischemic insult known as key factor in exacerbating brain damage. Thus, RONS scavengers that can block excessive production have great therapeutic potential. Herein, we propose an efficient treatment strategy which artificial nanozyme with multienzyme activity drives neuroprotection against primarily by scavenging RONS. Specifically,...
The overproduction of reactive oxygen species (ROS) is central to the progression inflammatory bowel disease (IBD), which may be potential therapeutic target. Prussian blue (PB) nanoparticles with good biosafety can act as an artificial nanozyme, effectively scavenging ROS. To date, PB-based nanomaterials have not been developed and utilized for treatment IBD. In this study, poly(vinylpyrrolidone)-modified (PPB) are constructed physiological stability by a simple efficient method. prepared...
The overproduction of reactive oxygen species (ROS) is linked to inflammatory bowel disease (IBD) and causes oxidative damage DNA, proteins, lipids. These ROS promote the initiation progression ulcerative colitis (UC). This study proposes a unique concept nanomaterials with intrinsic enzyme-like activity (nanozymes) mediate catalytic nanotherapy for IBD. Methods: We first synthesized manganese Prussian blue nanozymes (MPBZs) multi-enzyme activity. A dextran sulfate sodium (DSS)-induced mouse...
The integration of efficient imaging for diagnosis and synergistic tumor therapy into a single‐component nanoplatform is much promising high efficacy treatment but still in great challenge. Herein, smart versatile nanotheranostic platform based on hollow mesoporous Prussian blue nanoparticles (HMPBs) with perfluoropentane (PFP) doxorubicin (DOX) inside, has been designed, the first time, to achieve distinct vivo chemo‐thermal synchronous monitoring by ultrasound (US)/photoacoustic (PA) dual...
Prussian blue (PB) has been used as a photothermal conversion agent to generate heat induce localized damage tumor. However, its therapeutic efficiency is far from satisfactory. One of the major obstacles that maximum NIR absorption peak PB within 690-720 nm cannot be optimized near wavelength laser enhance efficiency. Herein, we report integration Gd3+ into nanocrystals (GPB NCs) enables with tunable surface plasmon resonances (LSPRs) 710 910 nm, achieving laser. Concurrently, dual-mode...
Magnetic hyperthermia therapy (MHT) has been considered as an excellent alternative for treatment of deep tumor tissue; however, up-regulation heat shock proteins (HSPs) impairs its hyperthermal therapeutic effect. Reactive oxygen species (ROS) and competitive consumption ATP are important targets that can block excessive HSP generation. We developed a magnetic nanocatalytic system comprised glucose oxidase (GOD)-loaded hollow iron oxide nanocatalysts (HIONCs) to drive...
Abstract Background Macrophage polarization and reprogramming in the lung play a critical role initiation, development progression of acute injury (ALI). Regulating activation differentiation pulmonary macrophages may provide potential therapeutic strategy to treat ALI. We previously developed novel class anti-inflammatory nanoparticles (P12) that can potently inhibit Toll-like receptor (TLR) signaling macrophages. These bioactive nanodevices were made gold (GNPs) coated with hexapeptides...
High-intensity focused ultrasound (HIFU) is deemed to be a promising noninvasive therapeutic modality for cancers as well non-neoplastic diseases.However, the accuracy of technique in diagnosis and treatment tumors remains unsatisfactory.HIFU, when combined with multifunctional synergistic agents (SAs), has potential greater diagnostic efficacy.Here we describe smart hollow mesoporous Prussian blue (HMPBs) theranostic nanoplatform, structure which capable encapsulating doxorubicin (DOX)...
Osteoarthritis (OA) is the main cause of disability in elderly. Effective intervention early and middle stage osteoarthritis can greatly prevent or slow down development disease, reduce probability joint replacement. However, there to date no effective for middle-stage OA. OA microenvironment mainly destroys balance oxidative stress, extracellular matrix synthesis degradation chondrocytes under action biological mechanical factors. Herein, hollow Prussian blue nanozymes (HPBzymes) were...
Acute pancreatitis (AP) is a serious acute condition affecting the abdomen and shows high morbidity mortality rates. Its global incidence has increased in recent years. Inflammation oxidative stress are potential therapeutic targets for AP. This study was conducted to investigate intrinsic anti-oxidative anti-inflammatory effects of Prussian blue nanozyme (PBzyme) on AP, along with its underlying mechanism.
Abstract Acute respiratory distress syndrome (ARDS) is a common critical with no effective therapeutic intervention. Neutrophils function in the overwhelming inflammatory process of acute lung injury (ALI) caused by ARDS; however, phenotypic heterogeneity pulmonary neutrophils ALI/ARDS remains largely unknown. Here, using single-cell RNA sequencing, we identify two transcriptionally and functionally heterogeneous neutrophil populations (Fth1 hi Neu Prok2 Neu) distinct locations LPS-induced...
Ischemia-reperfusion (I/R) injury leads to a low success rate of skin flap transplantation in reconstruction surgery, thus requiring development new treatments. Necroptosis and apoptosis pathways, along with overexpression reactive oxygen species pro-inflammatory factors transplantation, are deemed as potential therapeutic targets. This study provides paradigm for nanozyme-mediated microenvironment maintenance improve the survival transplanted flap. Prussian blue nanozyme (PBzyme) multiple...
ConspectusNanomedicine is an interdisciplinary science that involves chemistry, materials, physics, engineering, biology, and medicine. The main focus of nanomedicine on drug carriers: how to improve efficacy reduce side effects. In order further the synergistic detoxifying effects nanomedicines, scientists have adopted a multifunctional integration strategy. However, versatility brings complex components ignores between components. lack in-depth research bioactivities nanocarriers hinders...
Abstract Background Photothermal therapy (PTT), involving application of localized hyperthermia to kill cancer cells, has attracted wide attention in therapy. The production reactive oxygen species (ROS) during PTT may cause irreversible damage healthy tissues around the tumor. Simultaneously, can stimulate inflammatory response, thus promoting tumor recurrence and metastasis. Therefore, it is paramount importance reduce undesired side effects for further development PTT. Results Using a...
Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical that currently has no effective therapeutic interventions. Pulmonary macrophages play principal role in the initiation and progression of overwhelming inflammation ALI/ARDS. Here, type fluorous‐tagged bioactive peptide nanoparticle termed CFF13F developed, which can be efficiently internalized by suppress excessive expression cytokines overproduction reactive oxygen species (ROS) triggered...
Background The triple negative breast cancer (TNBC) is the most malignant subtype of with high aggressiveness. Although paclitaxel-based chemotherapy scenario present mainstay in TNBC treatment, paclitaxel resistance still a striking obstacle for cure. So it imperative to probe new therapeutic targets through illustrating mechanisms underlying chemoresistance. Methods Single cell RNA sequencing (scRNA-seq) data cells treated at different points were downloaded from Gene Expression Omnibus...