A5101468274- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Pelvic floor disorders treatments
- Ultrasound Imaging and Elastography
- Ultrasound and Cavitation Phenomena
- Prostate Cancer Diagnosis and Treatment
- Particle physics theoretical and experimental studies
- Nanoparticle-Based Drug Delivery
- Thyroid Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Urinary and Genital Oncology Studies
- Pelvic and Acetabular Injuries
- Peripheral Nerve Disorders
- Advanced Nanomaterials in Catalysis
- Ultrasonics and Acoustic Wave Propagation
- Quantum Chromodynamics and Particle Interactions
- MRI in cancer diagnosis
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Urinary Bladder and Prostate Research
- Computational Physics and Python Applications
- Renal cell carcinoma treatment
Shanghai Sixth People's Hospital
2014-2025
Shanghai Jiao Tong University
2015-2025
Huaneng Clean Energy Research Institute
2025
Dalian Minzu University
2023
Minzu University of China
2023
Shanghai Institute of Hematology
2013-2022
Guodian Institute of Science and Technology
2021-2022
Nanjing University of Posts and Telecommunications
2022
CRRC (China)
2022
Shanghai Eighth People Hospital
2021
Ischemic stroke is a devastating disease and one of the leading causes mortality worldwide. Overproduction reactive oxygen nitrogen species (RONS) following ischemic insult known as key factor in exacerbating brain damage. Thus, RONS scavengers that can block excessive production have great therapeutic potential. Herein, we propose an efficient treatment strategy which artificial nanozyme with multienzyme activity drives neuroprotection against primarily by scavenging RONS. Specifically,...
The overproduction of reactive oxygen species (ROS) is linked to inflammatory bowel disease (IBD) and causes oxidative damage DNA, proteins, lipids. These ROS promote the initiation progression ulcerative colitis (UC). This study proposes a unique concept nanomaterials with intrinsic enzyme-like activity (nanozymes) mediate catalytic nanotherapy for IBD. Methods: We first synthesized manganese Prussian blue nanozymes (MPBZs) multi-enzyme activity. A dextran sulfate sodium (DSS)-induced mouse...
Ferroptosis is a regulated form of necrotic cell death that involves the accumulation lipid peroxide (LPO) species in an iron- and reactive oxygen (ROS)-dependent manner. Previous investigations have reported ferroptosis-based cancer therapy can overcome limitations traditional therapeutics targeting apoptosis pathway. However, it still challenging to enhance antitumor efficacy ferroptosis due intrinsic cellular regulation. In this study, ferroptosis-inducing agent, i.e., chlorin e6...
Evidence shows that administration of D-galactose (D-gal) induces reactive oxygen species (ROS) production and inflammatory response resulting in neurodegenerative changes. Ursolic acid (UA), a triterpenoid compound, has been reported to possess antioxidant anti-inflammatory properties. Our previous studies have demonstrated UA could protect mouse brain against D-gal-induced oxidative damage. In the present study, we examined protective effect prefrontal cortex explored potential mechanism...
Magnetic hyperthermia therapy (MHT) has been considered as an excellent alternative for treatment of deep tumor tissue; however, up-regulation heat shock proteins (HSPs) impairs its hyperthermal therapeutic effect. Reactive oxygen species (ROS) and competitive consumption ATP are important targets that can block excessive HSP generation. We developed a magnetic nanocatalytic system comprised glucose oxidase (GOD)-loaded hollow iron oxide nanocatalysts (HIONCs) to drive...
Understanding the surrounding environment of vehicle is still one challenges for autonomous driving. This paper addresses 360-degree road scene semantic segmentation using surround view cameras, which are widely equipped in existing production cars. First, order to address large distortion problem fisheye images, Restricted Deformable Convolution (RDC) proposed segmentation, can effectively model geometric transformations by learning shapes convolutional filters conditioned on input feature...
Abstract Nanozymes are widely applied for treating various major diseases, including neurological diseases and tumors. However, the biodegradability of nanozymes remains a great challenge, which hinders their further clinical translation. Based on microenvironment osteoarthritis (OA), representative pH‐responsive biodegradable hollow‐structured manganese Prussian blue nanozyme (HMPBzyme) is designed treatment OA. HMPBzyme with good biodegradability, biocompatibility, multi‐enzyme activities...
Fe<sub>3</sub>O<sub>4</sub> nanoparticles were assembled into a zeolitic-imidazole framework to form pH- and glutathione-responsive <italic>T</italic><sub>2</sub>–<italic>T</italic><sub>1</sub> switching contrast agent for sensitive tumor imaging.
Aiming at developing a moderate and efficient sono-photodynamic therapy for breast cancer, tissue engineering scaffolds may provide an easy strategy to eliminate serious side effects in conventional surgery or chemotherapy, thus, they are highly desired. However, the development of ideal therapeutic is always hindered by poor stability incompatibility between different biomaterial components. Herein, Food Drug Administration (FDA)-approved sono/photosensitizer Chlorin e6 (Ce6) was...
Objective To assess the usefulness of contrast–enhanced ultrasound (CEUS) in differentiating malignant from benign gallbladder (GB) diseases. Methods This study had institutional review board approval. 192 patients with GB diseases 9 university hospitals were studied. After intravenous bonus injection a phospholipid-stabilized shell microbubble contrast agent, lesions scanned low acoustic power CEUS. A multiple logistic regression analysis was performed to identify diagnostic clues 17...
Background The application of 22-MHz high-frequency ultrasound allows for visualization the inner part sural nerve. aim this study was to evaluate morphological changes nerves in patients with type 2 diabetes mellitus using ultrasound. Materials and Methods thickness/width (T/W) ratio, cross-sectional area (CSA) maximum thickness (MT) nerve fascicles were measured 100 50 healthy volunteers Receiver operating characteristic (ROC) curves plotted determine optimal cut-off values as well...
Objectives The purpose of this study was to determine the sonographic features thyroid follicular carcinoma in comparison with adenoma. Methods This retrospective included 36 pathologically proven carcinomas (5 widely invasive and 31 minimally invasive) 52 adenomas 88 patients who underwent surgery. We analyzed each tumor, including maximum diameter, peripheral halo, echogenicity, echo texture, calcifications, nodularity. frequencies were compared by χ2 Fisher exact tests between carcinomas....
The aim of this study was to compare the value superb microvascular imaging (SMI) in carpal tunnel syndrome (CTS) with that color Doppler ultrasonography (CDUS) and power (PDUS). Fifty patients symptomatic CTS 25 healthy volunteers were enrolled. cross-sectional area (CSA), CDUS score, PDUS SMI score median nerve (MN) at recorded. different (US) diagnostic strategies calculated. blood flow display ratio MN had no statistical difference between CDUS, PDUS, (20%, 32%, 48%, respectively, P...
To overcome the toxicity of chemotherapy, increasing attention has been paid to local drug delivery systems (DDSs). pH-Sensitive hydrogels have emerged as promising DDS materials in biomedical field due their remarkable characteristics. However, pH environment tumor varies from person person, which makes applicability based on challenging. In this study, we developed a contractible hydroxypropyl methyl cellulose (HPMC)/Fe3O4 hydrogel with dual-response and magnetic properties aiming...
Abstract Totally 85 patients with 93 renal lesions who underwent contrast-enhanced ultrasound (CEUS) were retrospectively studied quantitative analysis to evaluate its value in the differential diagnosis of tumor histotypes. CEUS characteristics analysed including enhancement patterns, peak intensity, homogeneity enhancement, and pseudocapsule. Quantitative parameters intensity (P) time (TP) measured QontraXt software, index “relative percentage” ΔP% “difference TP between cortex” ΔTP used...
To assess the respective diagnostic value of Sonazoid™ and SonoVue® for characterizing FLLs as benign or malignant corresponding safety.