A5101952746- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Extracellular vesicles in disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Acute Myocardial Infarction Research
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Hepatitis B Virus Studies
- Noise Effects and Management
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
Army Medical University
2015-2025
Wuhan University
2013-2024
Renmin Hospital of Wuhan University
2017-2024
University of Maryland, Baltimore
2023
Fujian Medical University
2023
Genesee Community College
2023
Southern University of Science and Technology
2022
Jinan University
2014-2022
Zhongnan Hospital of Wuhan University
2010-2022
Xinjiang Medical University
2015-2020
Rationale: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in world. Apart from traditional surgical resection, radiotherapy, and chemotherapy, more recent techniques such as nano-photothermal therapy biotherapy are gradually being adopted for treatment HCC. This project intends to combine advantages nanoscale drug delivery systems with targeting ability CAR-T cells. Method: Based on cell membrane-coated nanoparticles membrane-targeting modifications, a novel...
Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators tumorigenesis and metastasis in HCC. In this study, we investigated the functional significance SNHG12 explored whether can directly interact with miR-199a/b-5p progression We determined expression level HCC tissues quantitative real-time PCR then studied its clinical significance. The binding site between was confirmed...
Targeted therapy based on adjustment of microRNA (miRNA)s activity takes great promise due to the ability these small RNAs modulate cellular behavior. However, efficacy miR-101 replacement hepatocellular carcinoma (HCC) remains unclear. In current study, we first observed that plasma levels were significantly lower in distant metastatic HCC patients than HCCs without metastasis, and down-regulation predicted a worse disease-free survival (DFS, P<0.05). an animal model HCC, demonstrated...
Specific targeted drug delivery and controllable release of drugs at tumor regions are two the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.
Abstract Metabolic interventions via targeting intratumoral dysregulated metabolism pathways have shown promise in reinvigorating antitumor immunity. However, approved small molecule immunomodulators often suffer from ineffective response rates and severe off‐target toxicity. ATP occupies a crucial role energy of components that form the tumor microenvironment (TME) influences cancer immunosurveillance. Here, nanocarrier‐assisted immunometabolic therapy strategy targets ATP‐adenosine axis...
Abstract Hepatocellular carcinoma (HCC) is a highly lethal malignant tumor, and the current non‐invasive diagnosis method based on serum markers, such as α‐fetoprotein (AFP), des‐γ‐carboxy‐prothrombin (DCP), has limited efficacy in detecting it. Therefore, there critical need to develop novel biomarkers for HCC. Recent studies have highlighted potential of exosomes biomarkers. To enhance exosome enrichment, silicon dioxide (SiO 2 ) microsphere‐coated three‐dimensional (3D) hierarchical...
This study aimed to assess the predictive value of 7 routinely available inflammation biomarkers for stroke and all-cause mortality in 229 non-valvular AF patients. C-reactive protein, Albumin (ALB), d-dimer, fibrinogen, number platelets, lymphocytes, monocyte neutrophils were measured. The Multivariable Cox proportional hazard model was used mortality, c-statistic, Net Reclassification Improvement (NRI), Integrated Discrimination (IDI) calculated. Lymphocyte Monocyte Ratio (LMR) most...
Abstract Background Circular RNA (circRNA) have been reported to play important roles in cardiovascular diseases including myocardial infarction and heart failure. However, the role of circRNA atrial fibrillation (AF) has rarely investigated. We recently found a hsa_circ_0099734 was significantly differentially expressed AF patients tissues compared paired control. aim investigate functional molecular mechanisms mmu_circ_0005019 which is homologous mice AF. Methods In order effect on...
Abstract Background To better search for potential markers hepatocellular carcinoma (HCC) invasion and metastasis, proteomic approach was applied to identify metastasis biomarkers associated with HCC. Methods Membrane proteins were extracted from MHCC97L HCCLM9 cells, a similar genetic background remarkably different potential, compared by SDS-PAGE identified ESI-MS/MS. The results further validated western blot analysis, immunohistochemistry (IHC) of tumor tissues HCCLM9- MHCC97L-nude mice,...
Non-small cell lung cancer (NSCLC) accounts for more than 80 % of all cancers, and its 5-year survival rate can be greatly improved by early diagnosis. However, diagnosis remains elusive because the lack effective biomarkers. In this study, we aimed to develop an diagnostic model NSCLC based on a combination circulating biomarkers.Tissue-deregulated long noncoding RNAs (lncRNAs) in were identified datasets retrieved from Gene Expression Omnibus (GEO, n=727) The Cancer Genome Atlas (TCGA,...