A5102898086- Lymphatic System and Diseases
- Thyroid and Parathyroid Surgery
- Breast Cancer Treatment Studies
- RNA Interference and Gene Delivery
- Thyroid Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Breast Implant and Reconstruction
- Bioinformatics and Genomic Networks
- Voice and Speech Disorders
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Advanced Proteomics Techniques and Applications
- Cancer Cells and Metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- AI in cancer detection
- RNA modifications and cancer
- Head and Neck Anomalies
- Cancer Research and Treatments
- Virus-based gene therapy research
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Airway Management and Intubation Techniques
- Cell Image Analysis Techniques
Zhongnan Hospital of Wuhan University
2014-2025
Wuhan University
2016-2025
Nanjing Drum Tower Hospital
1993-2017
University of Nebraska Medical Center
2010-2014
Beijing University of Posts and Telecommunications
2014
Environmental Molecular Sciences Laboratory
2010
Pacific Northwest National Laboratory
2010
Duke University
2007
Institut Gustave Roussy
2006-2007
Memorial Sloan Kettering Cancer Center
2007
Abstract Background Dendritic cells (DCs) are central for the initiation and regulation of innate adaptive immunity in tumor microenvironment. As such, many kinds DC-targeted vaccines have been developed to improve cancer immunotherapy numerous clinical trials. Targeted delivery antigens adjuvants DCs vivo represents an important approach development DC vaccines. However, nonspecific activation systemic preparation optimal immunodominant still represent major challenges. Methods We loaded...
Abstract Imaging flow cytometry (IFC) combines the imaging capabilities of microscopy with high throughput cytometry, offering a promising solution for high-precision and high-throughput cell analysis in fields such as biomedicine, green energy, environmental monitoring. However, due to limitations framerate real-time data processing, existing IFC systems has been restricted approximately 1000-10,000 events per second (eps), which is insufficient large-scale analysis. In this work, we...
Abstract Background KIAA1199 is a recently identified novel gene that up-regulated in human cancer with poor survival. Our proteomic study on signaling polarity chemotactic cells revealed as protein target may be involved cellular chemotaxis and motility. In the present study, we examined functional significance of expression breast growth, motility invasiveness. Methods We validated previous microarray observation by tissue immunohistochemistry using TMA slide containing 12 tumor cores...
6018 Background: Medullary thyroid cancer (MTC) is the most common cause of death in patients with hereditary syndromes caused by activating mutations RET protooncogene. activation initial oncogenic event, activity other receptor tyrosine kinases, including VEGFR and EGFR, likely to contribute tumor growth metastasis. Vandetanib (ZD6474) a once- daily oral agent that selectively targets RET, EGFR kinases. Methods: Eligible had unresectable, measurable, locally advanced or metastatic MTC...
Failure detection module is one of important components in fault-tolerant distributed systems, especially cloud platform. However, to achieve fast and accurate failure becomes more difficult when network other resources' status keep changing. This study presented an efficient adaptive mechanism based on volterra series, which can use a small amount data for predicting. The uses filter time series prediction decision tree making. Major contributions are applying prediction, introducing user...
Breast cancer is one of the most prevalent diseases for women worldwide. Early and accurate ultrasound image segmentation plays a crucial role in reducing mortality. Although deep learning methods have demonstrated remarkable potential, they still struggle with challenges images, including blurred boundaries speckle noise. To generate segmentation, this paper proposes Edge-Aware Multi-Scale Group-Mix Attention Network (EMGANet), which generates by integrating edge features. The Group Mix...
Here we present a novel and robust method for the identification of protein S-nitrosylation sites in complex mixtures. The approach utilizes cysteinyl affinity resin to selectively enrich S-nitrosylated peptides reduced by ascorbate followed nanoscale liquid chromatography tandem mass spectrometry. Two alkylation agents with different added masses were employed differentiate from non-S-nitrosylation sites. We applied this MDA-MB-231 cells treated Angeli's salt, nitric oxide donor that has...
Abstract Background To better search for potential markers hepatocellular carcinoma (HCC) invasion and metastasis, proteomic approach was applied to identify metastasis biomarkers associated with HCC. Methods Membrane proteins were extracted from MHCC97L HCCLM9 cells, a similar genetic background remarkably different potential, compared by SDS-PAGE identified ESI-MS/MS. The results further validated western blot analysis, immunohistochemistry (IHC) of tumor tissues HCCLM9- MHCC97L-nude mice,...
5533 Background: Medullary thyroid carcinoma (MTC) is the most common cause of death in patients with hereditary syndromes caused by specific mutations RET protooncogene. activation oncogenic event, which results intrinsic receptor tyrosine kinase activity, but other pathways, such as VEGFR- and EGFR-dependent signaling, also participate tumor growth development. ZD6474 a once-daily oral agent that selectively targets RET, VEGFR EGFR kinases. The clinical activity was evaluated MTC. Methods:...
Abstract Background Gene therapy is a promising therapeutic approach for cancer. Targeted expression of desired proteins within the tumor best to reduce toxicity and improve survival. This study establish more effective less toxic gene Methods Combined strategy with recombinant adenovirus expressing horseradish peroxidase (HRP) mediated by human telomerase reverse transcriptase (hTERT) promoter (AdhTERTHRP) murine interleukin-12 (mIL-12) under control Cytomegalovirus (CMV) (AdCMVmIL-12) was...
Abstract Background c-Met is a receptor tyrosine kinase (RTK) that over-expressed in variety of cancers and involved cell growth, invasion, metastasis angiogenesis. In this study, we investigated the role rhabdomyosarcoma (RMS) using its small molecule inhibitor SU11274, which has been hypothesized to be potential therapeutic target for RMS. Methods The expression level phosphorylated RMS lines (RD, CW9019 RH30) tumor tissues was assessed by phospho-RTK array immunohistochemistry,...
Breast cancer (BC) is the most common neoplastic and lethal malignancy in women. Although antiendocrine therapy main treatment for estrogen receptor alpha (ERα)-positive BC, development of resistance a major clinical complication. In this study, we aimed to explore role ubiquitin-specific peptidase 8 (USP8) ERα signaling identify potential targets endocrine resistance. Public databases were used analyze USP8 expression, prognosis, characteristics, immune cell infiltration....
Esophageal squamous cell carcinoma (ESCC) is a common malignancy with poor prognosis and survival rate. To identify meaningful lncRNA, microRNA, mRNA modules related to the ESCC prognosis, TCGA-ESCC was downloaded processed, then weighted gene co-expression network analysis applied construct lnRNA networks, miRNA networks networks. Twenty-one hub lncRNAs, seven miRNAs, eight mRNAs were clarified. Meanwhile, lncRNA–miRNA–mRNA constructed, emerging role of being involved in head neck (HNSCC)...