A5102000817- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- AI in cancer detection
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Growth Hormone and Insulin-like Growth Factors
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Cancer Treatment and Pharmacology
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Brain Tumor Detection and Classification
- Fibroblast Growth Factor Research
- Chemokine receptors and signaling
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
Sir Run Run Shaw Hospital
2024-2025
Zhejiang University
2019-2025
Harbin Medical University
2023-2024
Second Affiliated Hospital of Harbin Medical University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Weatherford College
2023
Hangzhou First People's Hospital
2023
Hubei University of Medicine
2022
Acetaminophen (APAP)-induced liver injury (AILI) is a common disease in clinical practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI available clinics, but novel strategies are still needed due to complicated pathological changes and side effects NAC. Here, we found that astaxanthin (ASX) can prevent through Nrf2/HO-1 pathway. After with ASX, there was positive activation pathway models both vivo vitro accompanied by enhanced autophagy reduced...
Abstract The development of colitis‐associated colorectal cancer is known to be associated with the inflammation‐dysplasia‐carcinoma pathway, and thus, chronic inflammation represents an inducer promoter cancer. To inhibit evolution from colitis provide efficient anticancer therapy, a surface‐engineered vanadium carbide MXene nanoenzyme (MXenzyme) developed both amino functionalization gallium doping (Ga/V 2 C‐NH ). Benefiting multiple enzyme‐mimicking activities, MXenzymes have shown great...
Abstract Clear cell renal carcinoma (ccRCC) is the predominant subtype of cancer and highly malignant. Despite advances in diagnostics treatment, prognosis for ccRCC remains poor. The dual nature (promotion or inhibition) S100A2 different types shows complex involvement its tumorigenesis, but effect unclear. In this study, we first elucidate tumor-promoting function by reprogramming glycolysis. Mechanistically, demonstrate that accelerates progression through interaction with transcription...
Breast cancer is one of the most prevalent diseases for women worldwide. Early and accurate ultrasound image segmentation plays a crucial role in reducing mortality. Although deep learning methods have demonstrated remarkable potential, they still struggle with challenges images, including blurred boundaries speckle noise. To generate segmentation, this paper proposes Edge-Aware Multi-Scale Group-Mix Attention Network (EMGANet), which generates by integrating edge features. The Group Mix...
Abstract Background Precise and rapid ultrasound‐based breast cancer diagnosis is essential for effective treatment. However, existing ultrasound image segmentation methods often fail to capture both global contextual features fine‐grained boundary details. Purpose This study proposes a dual‐branch network architecture that combines the Swin Transformer Segment Anything Model (SAM) enhance (BUSI) accuracy reliability. Methods Our integrates attention mechanism of with detection from SAM...
Abstract Aims The ageing global population and overall growth have significantly increased the burden of cardiovascular diseases (CVDs). This study aims to examine temporal trends in incidence, disability-adjusted life years (DALYs), mortality rates both type-specific CVDs among adults aged 55 older from 1990 2021, with a focus on identifying changes over time, regional disparities, key risk factors contributing this burden. Methods results We analysed data Global Burden Disease Study...
Background: Hepatic ischemia reperfusion injury (HIRI) is a common not only during liver transplantation but also major hepatic surgery. HIRI causes severe complications and affects the prognosis survival of patients. Cuproptosis, newly identified form cell death, plays an important role in variety illnesses. However, its remains unknown. Materials methods: The GSE151648 dataset was mined from Gene Expression Omnibus (GEO) database, differences were analyzed for intersections. Based on...
The aim of this study was to compare the efficacy, cardiotoxicity and factors affecting pathologic complete response (pCR) neoadjuvant chemotherapy (NACT) regimen TCbHP (docetaxel/nab-paclitaxel, carboplatin, trastuzumab pertuzumab) AC-THP (doxorubicin, cyclophosphamide followed by docetaxel/nab-paclitaxel, for human epidermal growth factor receptor 2-positive (HER2+) early-stage breast cancer at a retrospective cohort.This included patients with HER2+ who received NACT or then underwent...
Disparities in serum biomarker levels related to mortality persist within the US diabetic population. We conducted a study explore impact of alkaline phosphatase (ALP) on all-cause and cardiovascular disease (CVD) type 2 diabetes patients.
Abstract Our previous study demonstrated that tumor-suppressor circular RNAs (circRNAs) can be specifically secreted outside of colorectal cancer (CRC) cells within exosomes to maintain tumor cell fitness. However, whether tumor-driving circRNAs retained in facilitate progression remains unknown. In this study, circRNA-seq showed circSKA3 was significantly upregulated CRC tissues but downregulated serum samples from patients. addition, promoted vitro and vivo via a specific cellmotif...
Epigenetic alterations contribute greatly to metastasis and dissemination in hepatocellular carcinoma (HCC). SMARCC1, as a SWI/SNF chromatin remodeling factor, has been reported play important roles many cancers. For the first time, with bioinformatics analysis wet-bench experiments, we explored biological significance of SMARCC1 its potential putative therapeutic target HCC.The mRNA expression profiles prognostic value were analyzed Oncomine, UALCAN Kaplan-Meier Plotter databases. The...
Abstract Liver metastasis is a major cause of morbidity and mortality in patients with colorectal cancer. A better understanding the biological mechanisms underlying liver tropism cancer could help to identify improved prevention treatment strategies. In this study, we performed genome-wide CRISPR loss-of-function screening mouse model identified deficiency AFDN, protein involved establishing maintaining cell–cell contacts, as driver metastasis. Elevated AFDN expression was correlated...
Abstract Objectives Cyclin-dependent kinase 19 (CDK19) is a component of the mediator coactivator complex, which required for transcriptional activation. In this study, we utilized public databases and wet-bench hepatic cell line experiments to elucidate potential roles CDK19 in hepatocellular cancer (HCC). Materials methods We studied relationships between expression several clinical features related HCC via Oncomine UALCAN databases. The prognostic value was tested using Kaplan–Meier...
Aims Hypoalbuminemia can lead to underestimations of the true anion gap levels. There are few data on albumin-corrected serum (ACAG) status and mortality in diabetes. The study aimed examine association between ACAG all-cause, cardiovascular, cancer type 2 diabetes (T2D) patients. Methods Herein, 8,161 diabetic adults were included National Health Nutrition Examination Survey (NHANES) 1999-2018. Mortality Index (NDI) used for determining outcomes through 31 December 2019. Cox proportional...
Early diagnosis is an effective strategy for decreasing breast cancer mortality. Ultrasonography one of the most predominant imaging modalities owing to its convenience and non-invasiveness. The present study aimed develop a model that integrates age with Breast Imaging Reporting Data System (BI-RADS) lexicon improve diagnostic accuracy ultrasonography in cancer. This retrospective comprised two cohorts: A training cohort 975 female patients from Renmin Hospital Wuhan University (Wuhan,...
IGFBP6, a member of the IGF binding protein (IGFBP) family, is specific inhibitor insulin-like growth factor II (IGF-II) and can inhibit malignant tumors overexpressing IGF-II. Type 2 diabetes (T2D) basic disorder glucose metabolism that be regulated by IGF-related pathways. We performed bioinformatics analysis TCGA database to explore possible mechanism IGFBP6 in breast cancer (BC) prognosis collected clinical samples from BC patients with without T2D compare verify prognostic effect...