A5052925716- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Global Cancer Incidence and Screening
- Cancer Treatment and Pharmacology
- Breast Lesions and Carcinomas
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Multiple and Secondary Primary Cancers
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Lung Cancer Treatments and Mutations
Xinjiang Institute of Materia Medica
2025
Wuhan University
2025
China Medical University
2025
Fourth Affiliated Hospital of China Medical University
2025
Jiangsu Province Hospital
2020-2024
Nanjing Medical University
2018-2024
Nanjing University of Chinese Medicine
2024
West China Medical Center of Sichuan University
2024
Qingdao University
2015-2023
Affiliated Hospital of Qingdao University
2015-2023
Abstract Sepsis is a systemic inflammatory response syndrome caused by infection, resulting in organ dysfunction. Sepsis‐induced acute kidney injury (AKI) one of the most common potential complications. Increasing reports have shown that M1 and M2 macrophages both take part progress AKI influencing level factors cell death, including pyroptosis. However, whether regulate secreting exosome remains unknown. In present study, we isolated exosomes from used Western blot enzyme‐linked...
Septic acute kidney injury (AKI) is characterized by inflammation. Pyroptosis often occurs during AKI and associated with the development of septic AKI. This study found that induction insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) to a higher level can induce pyroptosis in renal tubular cells. Meanwhile, macrophage migration inhibitory (MIF), subunit NLRP3 inflammasomes, was essential for IGF2BP1-induced pyroptosis. A putative m6A recognition site identified at 3'-UTR region...
Cancer-associated fibroblasts (CAFs) have been implicated in the development of resistance to anticancer drugs; however, role and mechanism underlying CAFs luminal breast cancer (BrCA) tamoxifen are unclear. We found that stromal isolated from central or peripheral area BrCA similar CAF phenotype activity. In vitro vivo experiments showed derived clinical–luminal BrCAs induce through decreasing estrogen receptor-α (ER-α) level when cultured with cell lines MCF7 T47D. promoted interleukin-6...
Epithelial–mesenchymal transition (EMT) is a complex physiological process that transforms polarized epithelial cells into moving mesenchymal cells. Dysfunction of EMT promotes the invasion and metastasis cancer. The architectural transcription factor high mobility group AT-hook 2 (HMGA2) highly overexpressed in various types cancer (e.g., colorectal cancer, liver breast uterine leiomyomas) significantly correlated with poor survival rates. Evidence indicated HMGA2 overexpression markedly...
Abstract Background Estrogen receptor (ER), progesterone (PgR), HER2, and Ki67 have been increasingly evaluated by core needle biopsy (CNB) are recommended for classifying breast cancer into molecular subtypes. However, the concordance rate between CNB open excision (OEB) has not well documented. Methods Patients with paired OEB samples from Oct. 2009 to Feb. 2012 in Ruijin Hospital were included. ER, PgR, determined immunohistochemistry (IHC). HER2 IHC 2+ further examined FISH. Cutoff value...
Abstract Background Despite extensive investigations on photothermal therapy, the clinical application is restricted due to poor stability, low therapeutic efficacy of therapy agents and its affinity loss in multistep synthesis delivery carriers. To address this, we designed an IR792-MCN@ZIF-8-PD-L1 siRNA (IM@ZP) nanoparticle drug system. IM@ZP was prepared by situ physical adsorption, followed characterization. Photothermal conversion ability assessed irradiation near-infrared (NIR) laser,...
Glioma is a highly malignant brain tumor with poor survival rate. The involvement of fatty acid metabolism in glioma was examined to find viable treatment options. information gathered from the Cancer Genome Atlas (TCGA) and Chinese (CGGA) databases. A prognostic signature containing metabolism-dependent genes (FAMDs) developed predict outcome by multivariate most minor absolute shrinkage selection operator (LASSO) regression analyses. In TCGA cohort, individuals good score had worse...
This study examined the 5-year survival of 2192 breast cancer women diagnosed between 1994 and 1997 in Ottawa, Canada, by age, TNM stage, histology, grade treatment, including assessment independent value variables defining prognosis. Our results showed that treatment significantly influenced outcome regardless confounding factors considered, with histology failing to achieve significant prognostic information. The rates were highest at ages 50–69 years for stage I 40–49 stages II–IV. lowest...
Abstract The tumor suppressor gene HIC1 is frequently deleted or epigenetically silenced in human cancer, where its restoration may improve cancer prognosis. Here, we report results illuminating how silencing alters effect signals triple-negative breast (TNBC), which are crucial for pathogenesis. expression was only TNBC compared with other molecular subtypes of cancer. Restoring cells reduced cell migration, invasion, and metastasis, whereas RNAi-mediated untransformed increased their...
CAFs isolated from HER2+ patients secreted higher levels of IL6 which expanded cancer stem cells and activated multiple pathways, then induced trastuzumab resistance in HER2 positive breast cells.
Triple negative breast cancer (TNBC) is an aggressive subtype of that often associated with a poor prognosis. The aim our study was to identify biomarkers predictive TNBC progression. Primary tissue samples including four metastasis and six without were subjected Affymetrix GeneChip® analysis (human genome U133). Ubiquitin-specific protease 2 (USP2) identified as upregulated gene in the metastatic group, its expression analyzed by immunohistochemistry 121 primary cancers, 13 paired normal...
Osteosarcoma is a quickly developing, malignant cancer of the bone, which associated with bad prognosis. In osteosarcoma, hypoxia promotes phenotype, results in cascade immunosuppressive processes, poor prognosis, and high risk metastasis. Nonetheless, additional methodologies for study hyperoxia tumor microenvironment also need more analysis. We obtained 88 children patients osteosarcoma from Therapeutically Applicable Research to Generate Effective Treatment (TARGET) database 53 RNA...
Background Evaluating tumor‐infiltrating lymphocytes (TILs) in patients with breast cancer using radiomics has been rarely explored. Purpose To establish a nomogram based on dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) for preoperatively evaluating TIL level. Study Type Retrospective. Population A total of 154 were divided into training cohort ( N = 87) and test 67), who further low (<50%) high (≥50%) subgroups according to the histopathological results. Field...
Breast cancer is one of the most prevalent diseases for women worldwide. Early and accurate ultrasound image segmentation plays a crucial role in reducing mortality. Although deep learning methods have demonstrated remarkable potential, they still struggle with challenges images, including blurred boundaries speckle noise. To generate segmentation, this paper proposes Edge-Aware Multi-Scale Group-Mix Attention Network (EMGANet), which generates by integrating edge features. The Group Mix...
Idiopathic pulmonary fibrosis (IPF), characterized by fibroblast activation and collagen deposition, is a progressive lung disease that lacks effective interventions. Ubiquitin-specific peptidase 10 (USP10) acts as multifunctional player in inflammatory response progression of cancers, the effect on unknown. Here, we demonstrated downregulated expression USP10 fibrotic tissues IPF patients. In current study, were collected at end weeks 1, 2, or 3 post bleomycin (BLM)-intratracheal delivery....
Everolimus, an mTOR inhibitor, showed great clinical efficacy in combination with tamoxifen, letrozole, or exemestane for the treatment of estrogen receptor-positive (ER+) breast cancer. However, its antitumor activity was shown to be compromised by a compensatory process involving AKT activation. Here, it determined whether combining additional PI3K inhibitor can reverse this phenomenon and improve efficacy. In cancer cells (MCF-7 BT474), everolimus inhibited downstream limiting...
Inflammation and tumor immune microenviroment are critical factors for prognosis in numerous cancers. The aim of this study was to determine the prognostic value preoperative neutrophil-to-lymphocyte ratio (NLR) breast cancer. We performed a retrospective analysis 487 patients diagnosed with primary cancer at Shanghai Ruijin hospital from January 2009 December 2010. Hematological parameters before surgery, clinicopathological data, survival status were obtained. Survival used evaluate NLR....