A5101810064- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Chemokine receptors and signaling
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Protease and Inhibitor Mechanisms
- Nanoplatforms for cancer theranostics
- Laser-Ablation Synthesis of Nanoparticles
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Advanced Breast Cancer Therapies
- Bone and Joint Diseases
Shanghai Jiao Tong University
2012-2023
Qingdao University
2022-2023
Affiliated Hospital of Qingdao University
2022-2023
Shanghai First People's Hospital
2016-2020
Ruijin Hospital
2013-2020
Shanghai Public Health Clinical Center
2013
The University of Sydney
2013
Shandong University
2010
Photothermal ablation (PTA) therapy has a great potential to revolutionize conventional therapeutic approaches for cancers, but it been limited by difficulties in obtaining biocompatible photothermal agents that have low cost, small size (<100 nm), and high conversion efficiency. Herein, we developed hydrophilic plate-like Cu(9)S(5) nanocrystals (NCs, mean of ∼70 nm × 13 nm) as new agent, which are synthesized combining thermal decomposition ligand exchange route. The aqueous dispersion...
Hydrophilic flower-like CuS superstructures synthesized by a hydrothermal route can serve as an efficient 980 nm laser-driven photothermal agent for ablation of cancer cells, because the exhibit greatly enhanced effects upon irradiation laser. This finding demonstrates great potential application in vivo tumor tissues.
Abstract Background Gastric cancer (GC) is a common form of malignant in worldwide which has poor prognosis. Despite recent improvements the treatment GC, prognosis not yet satisfactory for GC patients . CYT997, novel microtubule-targeting agent, recently been identified to be promising anticancer candidate cancers; however, effects CYT997 remain largely unknown. Methods Cell proliferation and apoptosis were detected by CCK8 assay flow cytometry. The mitochondrial ROS confocal microscope...
// Gang Xiao 1 , Xiumin Wang Jinglong Lidong Zu Guangcun Cheng Mingang Hao Xueqing Sun Yunjing Xue Jinsong Lu 2 and Jianhua 3 Department of Biochemistry Molecular Cell Biology, Shanghai Key Laboratory Tumor Microenvironment Inflammation, Jiao Tong University School Medicine, Shanghai, China Comprehensive Breast Health Center, Renji Hospital, Cancer Institute, Fudan Correspondence to: Wang, email: Lu, Keywords : CXCL16/CXCR6, breast cancer, ERK1/2, RhoA Received January 01, 2015 Accepted...
Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a multifunctional protein that can directly regulate apoptosis and metastasis. In this study, we investigated the functional molecular mechanisms by which TIMP-1 influences triple-negative breast cancer (TNBC). The expression level in tissues was analyzed using ONCOMINE microarray database. overall survival patients with distinct subtypes stratified levels evaluated Kaplan–Meier analysis. Bisulfate sequencing PCR (BSP) used to analyze...
Abstract Purpose: Prostate cancer is the second leading cause of deaths among men in Western counties, which has also occurred Chinese male with markedly increasing incidence recent years. Although mechanism underlying its progression still remains unclear, epigenetic modifications are important ethological parameters. The purpose this study to determine methylation status and function hypermethylatioted 1 (HIC1) prostate progression. Experimental Design: HIC1 promoter was assayed cell...
Increasing evidence shows that micro RNAs (miRNAs) play a critical role in tumor development. However, the of miRNAs non-small cell lung cancer (NSCLC) metastasis remains largely unknown. Here, we found miR-124 expression was significantly impaired NSCLC tissues and associated with its metastasis. In vitro vivo experiments indicate restoring cells had marked effect on reducing migration, invasion Mechanistic analyses show Smad4, cobinding protein transforming growth factor-β (TGF-β) pathway,...
Abstract The tumor suppressor gene HIC1 is frequently deleted or epigenetically silenced in human cancer, where its restoration may improve cancer prognosis. Here, we report results illuminating how silencing alters effect signals triple-negative breast (TNBC), which are crucial for pathogenesis. expression was only TNBC compared with other molecular subtypes of cancer. Restoring cells reduced cell migration, invasion, and metastasis, whereas RNAi-mediated untransformed increased their...
Triple negative breast cancer (TNBC) is an aggressive subtype of that often associated with a poor prognosis. The aim our study was to identify biomarkers predictive TNBC progression. Primary tissue samples including four metastasis and six without were subjected Affymetrix GeneChip® analysis (human genome U133). Ubiquitin-specific protease 2 (USP2) identified as upregulated gene in the metastatic group, its expression analyzed by immunohistochemistry 121 primary cancers, 13 paired normal...
Everolimus, an mTOR inhibitor, showed great clinical efficacy in combination with tamoxifen, letrozole, or exemestane for the treatment of estrogen receptor-positive (ER+) breast cancer. However, its antitumor activity was shown to be compromised by a compensatory process involving AKT activation. Here, it determined whether combining additional PI3K inhibitor can reverse this phenomenon and improve efficacy. In cancer cells (MCF-7 BT474), everolimus inhibited downstream limiting...
Metastatic disease is the leading cause of death due to prostate cancer (PCa). Although hypermethylated in 1 (HIC1) gene has been observed be epigenetically modified PCa, its intrinsic role and mechanism PCa metastasis still remain uncertain. Here, we show that hypermethylation HIC1 promoter markedly reduces suppressive function metastatic tissues as compared with primary adjacent normal tissues, associated poor patient survival. PCas cancer-prone mice homozygous for a prostate-targeted Hic1...
Non-small cell lung cancer (NSCLC), which accounts for more than 80% of cancers, is a leading cause mortality worldwide. However, the mechanism underlying its progression remains unclear. Here we found that HIC1 promoter was heavily methylated in NSCLC lines and tissues contributing to low expression compared normal controls. Restoring inhibited migration, invasion promoted inducible apoptosis cells. Notably, tumor suppressor through inhibiting transcription IL-6 by sequence-specific binding...
Colorectal cancer (CRC) is one of the most malignant cancers, and its incidence still steadily increasing. The DDX RNA helicase family members have been found to play a role in various cancers; however, DDX54 colorectal unclear needed be defined. Here, we was overexpressed CRC tissues by label-free mass spectrum, which also verified tissue microarray colon cancer, as well cell lines TCGA database. High level correlated with tumor stage distant metastasis, always indicated poor prognosis...
To test the hypothesis that activated extracellular signal-regulated kinase (ERK) regulates P65-miR23a/27a/24 axis in gastric cancer (GC) and ERK-P65-miR23a/27a/24 plays an important role development of GC, to evaluate gastrin GC progression axis. The component levels four fresh tissues, 101 paraffin-embedded tissues cell lines were determined by Western blotting, immunohistochemistry (IHC) or qRT-PCR. effects on first evaluated measuring serum 30 healthy 70 patients performing a correlation...
Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of stomach. It normally regulates gastric acid secretion and implicated a number human disease states, but how its function affects breast cancer (BC) development not documented. The current study investigated suppressive effects gastrin on BC underlying mechanisms.Serum levels were measured enzyme-linked immunosorbent assay (ELISA) correlation between level was analyzed chi-square test. Inhibitory...
Patients with epidermal growth factor receptor (EGFR)-sensitive mutations have great opportunity to benefit from EGFR-tyrosine kinase inhibitors (TKI) in non-small cell lung cancer (NSCLC). Although the presence of Kirsten rat sarcoma virus (KRAS) is predictive lack inhibitor therapy for NSCLC, patients KRAS could be more sensitive programmed death 1 (PD-1)/programmed death-ligand (PD-L1) inhibitors. However, application immunotherapy EGFR mutated NSCLC still controversial.In this study, we...
Abstract Background Although many prediction models in diagnosis of solitary pulmonary nodules (SPNs) have been developed, few are widely used clinical practice. It is therefore imperative to identify novel biomarkers and supporting early SPNs. This study combined folate receptor‐positive circulating tumor cells (FR + CTC) with serum biomarkers, patient demographics characteristics develop a model. Methods A total 898 patients nodule who received FR CTC detection were randomly assigned...
Steroid-associated osteonecrosis (SAON) mostly occurs in large joints such as hip that finally results joint collapse and replacement. An effective strategy for preventing SAON is inhibition of bone resorption lipid formation, whereas promoting formation at osteonecrotic-sensitive skeletal sites. The objective this study was to investigate whether gastrin administration could effectively prevent vivo had a significant effect on osteogenesis, osteoclast differentiation and/or adipogenesis...
Objectives Primary tumor tissue is often analyzed to search for predictive biomarkers and DNA-guided personalized therapies, but there an incomplete understanding of the discrepancies in genomic profiles between primary tumors metastases, such as liver lung metastases. Methods We performed in-depth targeted next-generation sequencing 520 key cancer-associated genes 47 matched metastatic samples which were retrospectively collected. Results A total 699 mutations detected samples. The...