A5101468109- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Oral and Maxillofacial Pathology
- Prostate Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- AI in cancer detection
- Bladder and Urothelial Cancer Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Radiomics and Machine Learning in Medical Imaging
- Metabolomics and Mass Spectrometry Studies
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Urologic and reproductive health conditions
- Immunotherapy and Immune Responses
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- FOXO transcription factor regulation
- Adipose Tissue and Metabolism
- Cancer Immunotherapy and Biomarkers
- Eating Disorders and Behaviors
Wuhan University of Technology
2025
Shanghai Jiao Tong University
2007-2023
Shanghai Sixth People's Hospital
2012-2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
NARI Group (China)
2023
Weatherford College
2023
Hubei Zhongshan Hospital
2023
University of Colorado Denver
2023
Peking Union Medical College Hospital
2021
Exosomes play crucial roles in regulating the crosstalk between normal and cancer cells tumor microenvironment, proliferation, migration invasion through their cargo molecules. We analyzed pro-invasiveness of exosomal circRNA-100,338 HCC using transwell assay. The co-culture human umbilical vein endothelial (HUVEC) exosomes derived from cell lines were used to evaluate impact on HUVEC. Nude mice models validate findings vitro. Clinically, quantitative RT-PCR was quantify expression serum...
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. Despite advances in diagnosis and treatment HCC, incidence, mortality continue to rise. For accurate there an urgent need precisely understand molecular mechanisms underlying HCC tumorigenesis progression. Accumulating evidence showed that circRNAs, which are normally produced by scrambling exons at splicing process, recognized as a novel class endogenous noncoding RNA, have microRNA sponging properties....
Breast cancer is one of the most prevalent diseases for women worldwide. Early and accurate ultrasound image segmentation plays a crucial role in reducing mortality. Although deep learning methods have demonstrated remarkable potential, they still struggle with challenges images, including blurred boundaries speckle noise. To generate segmentation, this paper proposes Edge-Aware Multi-Scale Group-Mix Attention Network (EMGANet), which generates by integrating edge features. The Group Mix...
Hypoxia is a common feature of many solid cancers and linked to malignant transformation, metastases treatment resistance. known induce hypoxia-inducible factor-1alpha (HIF-1alpha) expression. The aim this study investigate the impact overexpression HIF-1alpha on prognosis relationship with clinicopathological characteristics in human osteosarcoma.Immunochemistry digital image analysis was used determine protein expression histologic sections from 39 treated patients.According our study,...
Background/Aims: This aim of the present study was to identify specific markers determining recurrence giant cell tumor bone (GCTB). Methods: involved clinicopathological analysis 80 cases. All clinical features, pathological fracture, Campanacci grade, histological features and surgical methods were reviewed. Immunohistochemistry used detect expression Ki-67, CD147, mutant p53 p63 in GCTB. Comparisons between different groups performed using Chi-square test. The risk factors affecting...
Healthy longevity has been an unremitting pursuit of human, but its genetic and the environment causes are still unclear.As population is a good healthy aging model for understanding how body begin process aging, plasma lipids metabolism balance very important to life maintain physiologic functional turnover.It explore effect variants associated long-life individuals on balance.Therefore, we developed comparative study based which contains 2816 2819 control.Through whole-exome sequencing...
Background: Exosomal proteins from cancer cells are becoming new biomarkers for monitoring and efficacy evaluation. However, their biological function molecular mechanism underlying tumor metastasis largely unknown. Methods: Bioinformatic methods such as bulk gene expression analysis, single-cell RNA sequencing data set enrichment analysis were employed to identify metastasis-associated proteins. The in vitro vivo experiments used investigate the of RAB13 HCC metastasis. Results: We...
DNA methylation can induce carcinogenesis by silencing key tumor suppressor genes. Analysis of aberrant genes be used as a prognostic and predictive biomarker for cancer. In this study, we propose colorimetric method the detection paired box gene 1 (PAX1) in cervical scrapings obtained from 42 patients who underwent colposcopic biopsy.A thiolated methylation-specific polymerase chain reaction (MSP) primer was to generate MSP products labeled with thiol group at one end. After bisulfite...
To elucidate the clinicopathological features and diagnostic value of mutation specific antibody H3F3 K36M chondroblastoma (CB) in China.Clinicopathological profiles were retrieved, immunohistochemistry was performed on 185 CB specimens control group.Our series included 307 patients with a mean age 22.1 years. Long tubular bones (63.8%, 196/307) most commonly involved, followed by short hands feet (22.1%, 68/307), sesamoid (8.1%, 25/307), flat irregular (5.9%, 18/307). The involved site...
Muscle-invasive bladder cancer (MIBC) is originated in the muscle wall of bladder, and ninth most common malignancy worldwide. However, there are no reliable, accurate robust gene signatures for MIBC prognosis prediction, which importance assisting oncologists to make a more evaluation clinical practice. This study used univariable multivariable Cox regression models select build risk prediction model, respectively. The t-test fold change methods were perform differential expression...
The aim of the present study was to evaluate and compare effectiveness different imaging methods during follow-up prostatic radiofrequency ablation. Prostatic ablation (RFA) performed in 20 healthy beagle dogs. Various examinations were used monitor results RFA, including conventional ultrasound (US), contrast enhanced (CEUS) magnetic resonance (MR). Imaging exams at five phases: Immediately following one week later, month three months later six later. morphology for each test histological...
Prostate cancer is the second most common diagnosed in men. Due to low specificity of current diagnosis methods for detecting prostate cancer, identification new biomarkers highly desirable. The study was conducted determine clinical utility gene 3 (PCA3) assay predict biopsy-detected cancers Chinese included men who had a biopsy at Affiliated Sixth People's Hospital Shanghai Jiao Tong University from January 2013 December 2013. Formalin-fixed, paraffin-embedded tissue blocks were used test...