A5100735932- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
- CAR-T cell therapy research
- Lipid Membrane Structure and Behavior
- Advancements in Transdermal Drug Delivery
- Biopolymer Synthesis and Applications
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Antibiotics Pharmacokinetics and Efficacy
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Advanced Drug Delivery Systems
- Hemoglobin structure and function
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Virus-based gene therapy research
- Extracellular vesicles in disease
- Analytical Methods in Pharmaceuticals
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Phagocytosis and Immune Regulation
Zhejiang University
2010-2024
Jinhua Academy of Agricultural Sciences
2023
Fudan University
2016-2020
Nanjing Tech University
2017
Zhongshan Hospital
2016
American Pharmacists Association
2016
Augusta University
2013-2015
Georgia Regents Medical Center
2013-2015
Central South University
2013-2014
Third Xiangya Hospital
2013-2014
Bone defects caused by trauma, severe infection, tumor resection and skeletal abnormalities are common osteoporotic conditions major challenges in orthopedic surgery, there is still no effective solution to this problem. Consequently, new treatments needed develop regeneration procedures without side effects. Exosomes secreted mesenchymal stem cells (MSCs) derived from human induced pluripotent (hiPSCs, hiPSC-MSC-Exos) incorporate the advantages of both MSCs iPSCs with immunogenicity....
Abstract Immunotherapy is one of the key strategies for cancer treatment. The cGAS-cGAMP-STING-IRF3 pathway cytosolic DNA sensing plays a pivotal role in antiviral defense. We report that STING activator cGAMP possesses significant antitumor activity mice by triggering STING-dependent directly. enhances innate immune responses inducing production cytokines such as interferon-β, interferon-γ and stimulating dendritic cells activation, which induces cross-priming CD8 + T cells. mechanism was...
Tumors actively suppress antitumor immunity, creating formidable barriers to successful cancer immunotherapy. The molecular mechanisms underlying tumor-induced immune tolerance are largely unknown. In the present study, we show that dendritic cells (DC) in tumor microenvironment acquire ability metabolize vitamin A produce retinoic acid (RA), which drives regulatory T-cell responses and tolerance. Tolerogenic were dependent on induction of A-metabolizing enzymes via β-catenin/T-cell factor...
One of the major obstacles in treatment breast cancer is stem cells (BCSC) which are resistant to standard chemotherapeutic drugs. It has been proven that microRNA-200c (miR-200c) can restore sensitivity microtubule-targeting drugs by reducing expression class III β-tubulin. In this study, combination therapy with miR-200c and paclitaxel (PTX) mediated lipid nanoparticles was investigated as an alternative strategy against BCSC.A cationic 1,2-dioleoyl-3-trimethylammonium-propane...
Abstract Dendritic cells (DCs) sense microbes via multiple innate receptors. Signals from different receptors are coordinated and integrated by DCs to generate specific adaptive immune responses against pathogens. Previously, we have shown that two pathogen recognition receptors, TLR2 dectin-1, which recognize the same microbial stimulus (zymosan) on DCs, induce mutually antagonistic regulatory or inflammatory responses, respectively. How diametric signals these in regulate incite immunity...
Lymph nodes are proposed as the intriguing target in cancer immunotherapy, and cellular immunity is vital for vaccines to fight against cancer. However, inefficient delivery of lymph deficient lysosomal escape antigens result weak immunity, which restrains strength inducing antitumor immune responses. Hence, dendritic cell membrane (DCM)/histidine-modified stearic acid-grafted chitosan (HCtSA)/ovalbumin (OVA) micelles, pH-responsive biomimetic vaccines, were fabricated induce enhanced...
The tumor microenvironment (TME) contains high levels of the Wnt family ligands, and aberrant Wnt-signaling occurs in many tumors. Past studies have been directed toward how signaling cascade regulates cancer development, progression metastasis. However, its effects on host antitumor immunity remain unknown. In this report, we show that Wnts TME condition dendritic cells (DCs) to a regulatory state suppress immunity. DC-specific deletion co-receptors low-density lipoprotein receptor-related...
Abstract Despite intensive effort, the antitumor efficacy of tumor vaccines remains limited in treating established tumors regardless potent systemic tumor-specific immune response and increases infiltration T effector cells. In current study, we demonstrated that although lentivector (lv) immunization markedly increased Ag-dependent CD8 CD4 cells generated Ag-specific effect, it simultaneously absolute number myeloid-derived suppressor regulatory lesions. addition, lv induced expression...
The role of cGAMP stimulating cGAS-cGAMP-STING-IRF3 pathway to inhibit tumor growth was well-established. Herein, the efficiency and pharmacological mechanism on regulating metastasis investigated. effects CD8+ T cells myeloid-derived suppressor (MDSCs) in microenvironment explored. In this study, we found that boosted STING signaling activate production IFN-γ from cells, decreased population MDSCs vivo. CT26 bearing mice inhibited by via EMT process. played an important suppressing reactive...
Stemness and metastasis are the two main challenges in cancer therapy related to disease relapse post-treatment. They both have a strong correlation with chemoresistance poor prognosis, ultimately leading treatment failure. It has been reported that chemotherapy can induce stemness many types, especially chemotherapeutic agent doxorubicin (DOX) breast cancer. A combination is an efficient elegant approach through simultaneous delivery of or more drugs system for its synergistic effect, which...
Abstract Cancer vaccines, to date, have shown limited effect control the growth of established tumors due largely effector failure antitumor immune responses. Tumor lesion is characterized as chronic indolent inflammation in which function tumor-infiltrating lymphocytes (TILs) severely impaired. In this study, we investigated whether CD8 TILs could be rescued by converting milieu acute within tumors. We found that injection TLR3/9 ligands (polyI:C/CpG) into a tumor during phase lentivector...
High invasion and metastasis are the major obstacles to successful breast cancertherapy. Indocyanine green (ICG), a photosensitizer for photothermal therapy (PTT), shows potent anticancer efficacy when combined with chemotherapeutic drug doxorubicin (DOX). Human serum albumin (HSA), biocompatible carrier material, has been successfully used delivery of paclitaxel (Abraxane). In addition, there ICG functional binding regions in HSA. Thus, smart assembled nanoplatform (DI@HSA NPs) was...