Abstract Tumor growth and metastasis are the major causes of high mortality in breast cancer. In this study, a water‐responsive phospholipid‐calcium‐carbonate hybrid nanoparticle (PL/ACC‐DOX&ICG) surface modified with phospholipid shell is designed covered shielding polymer polyethylene glycol; development loaded photosensitizer indocyanine green (ICG) chemotherapeutic drug doxorubicin (DOX) for near‐infrared (NIR) imaging chemophotothermal combination therapy against PL/ACC‐DOX&ICG...

In the struggle against diseases, development of nano-therapy has certainly been a tremendous progression owing to various superiority, and chitosan is no doubt kind prominent biopolymer material with versatility for applications in disease treatments. For rational construction chitosan-related nano-biodevices, it necessary pay full attention itself, where properties that guide design criteria. Additionally, well-matched preparation methods between carriers therapeutic agents draw much final...

Ferroptosis as promising antitumor therapy strategy could be comprised by intracellular antioxidants, especially GSH and thioredoxin (Trx). They are both cofactors of Gpx4, the enzyme catalyzing production lipid peroxides to relieve oxidative stress, which drives acquired ferroptosis resistance in tumors. Herein, NADPH-consuming micelles specially designed, collaborate with ROS generating photodynamics (PDT) depleting Trx under hypoxia condition, resulting ruined redox homeostasis final...

Calcium (Ca2+ ) hemeostasis is crucial for the normal function of cellular biochemistry. The abnormal frequency Ca2+ signaling in cancer cells makes them more vulnerable to modulation than cells. Here this study, a novel cancer-specific therapy by artificially triggering overload proposed. feasibility illustrated successful coupling selective extrusion inhibition effect Curcumin (Cur) and effective generating capability amorphous calcium carbonate (ACC) into facilely prepared water...

Abstract Oxidative stress plays a critical role in the pathogenesis of ischemia‐reperfusion injury (IRI)‐induced acute kidney (AKI), driving necrosis proximal tubule cells, inflammation, and capillary rarefaction. Inadequate perfusion resulting from rarefaction can, turn, induce chronic tissue hypoxia exacerbate ischemic tubular necrosis, leading to an “oxidative stress‐microvascular perfusion” negative feedback that further aggravate damage. In this study, macrophage membrane‐camouflaged...

The critical process and step in achieving effective antitumor therapies is facilitating endosomal escape, which can enhance the intracellular target delivery of therapeutics. However, normally adopted approaches tend to result colloidal instability as a inevitable interactions between resulting positively charged surfaces micelles proteins vivo. Herein, negatively surface shielded polymeric micelles, consisting polymethylacrylamide derivatives hydrophilic chitosan (Mw = 18.8 kDa) linked by...

Rationale: Nano-carrier based combinational therapies for tumor cells hold great potential to improve the outcomes of patients.However, cancer associated fibroblasts (CAFs) in desmoplastic tumors and derived pathological stroma severely impede access sensitibity antitumor therapies.Methods: Glycolipid-based polymeric micelles (GLPM) were developed encapsulate an angiotensin II receptor I inhibitor (telmisartan, Tel) a cytotoxic drug (doxorubicin, DOX) respectively, which could exert efficacy...

Stemness and metastasis are the two main challenges in cancer therapy related to disease relapse post-treatment. They both have a strong correlation with chemoresistance poor prognosis, ultimately leading treatment failure. It has been reported that chemotherapy can induce stemness many types, especially chemotherapeutic agent doxorubicin (DOX) breast cancer. A combination is an efficient elegant approach through simultaneous delivery of or more drugs system for its synergistic effect, which...

Thermosensitive nanoparticles can be activated by externally applying heat, either through laser irradiation or magnetic fields, to trigger the release of drug payloads. This controlled mechanism ensures that drugs are specifically released at tumor site, maximizing their effectiveness while minimizing systemic toxicity and adverse effects. However, its efficacy is limited low concentration action sites, which caused no specific target sties. Herein, hyaluronic acid (HA), a gooey, slippery...

An insufficient drug concentration at the target site and efflux resulting in poor efficacy are recognized as important obstacles osteoporosis treatment. Simvastatin (SIM), which can treat by promoting osteoblast differentiation mineralization through bone morphogenetic proteins (BMP)-Smad signaling pathway, has lower bioavailability, less tissue distribution. Herein, novel lipid nanoparticles (LNPs) delivering SIM (SIM/LNPs) for therapy were developed with aspartic oligopeptide (ASP n ,...

Recently, nanotechnology-based drug delivery platforms in treating pulmonary arterial hypertension (PAH) have gradually emerged. However, large mechanical stress and shear blood vessels greatly affect the retention of nanopreparative materials at lesion sites, severely limiting delivery. Herein, a stimuli-responsive nanocraft is rationally designed by actively anchoring E-selectin overexpressed on endothelial cells (PAECs), under hypoxic conditions, allowing effective accumulation site....

Phototherapy is a potential new candidate for glioblastoma (GBM) treatment. However inadequate phototherapy due to stability of the photosensitizer and low target specificity induces proliferation neovascular endothelial cells angiogenesis causes poor prognosis.In this study, we constructed c(RGDfk)-modified glycolipid-like micelles (cRGD-CSOSA) encapsulating indocyanine green (ICG) dual-targeting tumor cells, cRGD-CSOSA/ICG mediated dual effect PDT/PTT with NIR irradiation.In vitro,...

Background: Photoactivity "on-off" switchable nano-agents could shield phototoxicity until reaching target region, which immensely promoted photodynamic therapy. However, the masking ratio of in vivo was dynamic and positively correlated with induced by laser irradiation, case timing irradiation unpredictable to maximize antitumor efficacy. Methods: Herein, low molecular weight chitosan hydrophobic polymethylacrylamide derivatives were linked via GSH cleavable 3, 3ʹ-dithiodipropionic acid...

The encapsulation of hydrophobic drugs is a problem that many researchers are working on. goal this study to achieve the delivery by means prodrugs and nanoformulations for stronger tumor cell-killing effect explore related killing mechanisms. Lipophilic quercetin (Qu) was covalently linked glyceryl caprylate-caprate (Gcc) via disulfide bonds-containing 3,3′-dithiodipropionic acid (DTPA) synthesize novel lipid Qu-SS-Gcc. Qu-SS-Gcc nanoparticles (Qu-SS-Gcc LNPs) were fabricated using solvent...

Bearing triazine-centered linkers, three primitive metal-organic frameworks (MOFs) with a Zr6O4 cluster have been prepared as ZrL1 (without any branch), ZrL2 (with -F), and ZrL3 -SCH3). The electrocatalytic hydrogen evolution reaction (HER) by their pristine transition metal-loaded (TM-loaded) forms was studied. It found that the loading of TM ions could enhance power these TM-loaded MOFs in HER, reflected lower overpotentials smaller Tafel slopes when compared MOFs. More importantly, best...