A5101509014- Inflammasome and immune disorders
- Lung Cancer Research Studies
- interferon and immune responses
- Nanoparticle-Based Drug Delivery
- Acupuncture Treatment Research Studies
- HIV Research and Treatment
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Traditional Chinese Medicine Studies
- RNA Interference and Gene Delivery
- Cancer therapeutics and mechanisms
- Metastasis and carcinoma case studies
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Facility Location and Emergency Management
- Environmental Quality and Pollution
- Insect symbiosis and bacterial influences
- IL-33, ST2, and ILC Pathways
- Blood donation and transfusion practices
- Immunotherapy and Immune Responses
- Advanced Neuroimaging Techniques and Applications
- Vehicle Routing Optimization Methods
- Biofield Effects and Biophysics
- Environmental and Agricultural Sciences
Zhejiang University
2020-2024
University of Chinese Academy of Sciences
2023-2024
Zhejiang Cancer Hospital
2014-2024
Betta Pharmaceuticals (China)
2024
Jiangnan University
2022-2023
Tongji University
2021
Shanghai Tenth People's Hospital
2021
Hainan Agricultural School
2021
Second Military Medical University
2021
Changhai Hospital
2021
Excessive inflammation caused by abnormal activation of the NLRP3 inflammasome contributes to pathogenesis multiple human diseases, but clinical drugs targeting are still not available. In this study, we identify entrectinib (ENB), a US Food and Drug Administration (FDA)-approved anti-cancer agent, as target inhibitor treat related diseases. ENB specifically blocks without affecting other inflammasomes. Furthermore, demonstrate that directly binds arginine 121 (R121) NEK7 interaction between...
Recent outbreak of flavivirus Zika virus (ZIKV) in America has urged the basic as well translational studies this important human pathogen. The nonstructural protein 5 (NS5) an N-terminal methyltransferase (MTase) domain that plays critical roles viral RNA genome capping. null mutant NS5 MTase is lethal for virus. Therefore, a potential drug target treatment infection. In study, we determined crystal structures ZIKV complex with GTP and cap analogue 7meGpppA. Structural analyses revealed...
Hydroxyurea (Green dots) efficiently promoted regional cerebral blood flow and increased BBB permeability. Thereby, more hypoxia-sensitive liposomes NIPP/ER@HL-D were transported to lesions entered brain exert anti-stroke efficacy.
Zika virus has attracted increasing attention because of its potential for causing human neural disorders, including microcephaly in infants and Guillain-Barré syndrome. Its NS3 helicase domain plays critical roles NTP-dependent RNA unwinding translocation during viral replication. Our structural analysis revealed a pre-activation state complex with GTPγS, which the triphosphate adopts compact conformation absence any divalent metal ions. In contrast, presence cation, GTPγS an extended...
Background: The calcium supplement is a clinically approved approach for osteoporosis therapy but usually requires large dosage without targetability and with poor outcome. This modality not fully explored in current due to the lack of proper carrier. Methods: In this study, we constructed tetracycline (Tc) modified simvastatin (Sim) loaded phospholipid-amorphous carbonate (ACC) hybrid nanoparticle (Tc/ACC/Sim). Results: resulted Tc/ACC/Sim was able enhance its accumulation at site. Most...
Thermosensitive nanoparticles can be activated by externally applying heat, either through laser irradiation or magnetic fields, to trigger the release of drug payloads. This controlled mechanism ensures that drugs are specifically released at tumor site, maximizing their effectiveness while minimizing systemic toxicity and adverse effects. However, its efficacy is limited low concentration action sites, which caused no specific target sties. Herein, hyaluronic acid (HA), a gooey, slippery...
The zebrafish genome encodes homologs for most of the proteins involved in inflammatory pathways; however, molecular components and activation mechanisms fish inflammasomes are largely unknown. ASC [apoptosis-associated speck-like protein containing a caspase-recruitment domain (CARD)] is only adaptor formation multiple types inflammasomes. Here, we demonstrate that zASC also inflammasome zebrafish. When overexpressed vitro vivo zebrafish, both pyrin (PYD) form speck filament structures....
Abstract The Hippo signaling pathway is critical for the regulation of organ development, tissue homeostasis, and tumorigenesis by controlling activation status yes-associated protein (YAP) or its homolog PDZ-binding motif (TAZ). As a major downstream effector, transcription factor TEAD activated forming complex with YAP/TAZ. aberrations leading to have been reported in many cancers. Inhibiting function directly blocking palmitoylation pocket potential therapeutic approach cancer treatment....
Because of the rarity thymoma, no randomized trials have prospectively detected prognosis and optimal treatment for type B2 thymoma. The aim this study is to investigate patients with We retrospectively evaluated outcome 42 thymoma who were treated between 1995 2010 in Zhejiang Cancer Hospital. Survival curves plotted using Kaplan–Meier method. Cox proportional hazard model was used multivariate analysis. current included patients. 5-year disease-free survival overall rates 62.8% 84.9%,...
Abstract Aims Dysfunction of the blood–brain barrier (BBB) is a prominent pathological feature glioblastoma (GBM). Vascular endothelial growth factor (VEGF) confirmed to be abnormally elevated in pathogenesis GBM, causing BBB disruption, which further allows leakage neurotoxic blood‐derived molecules into central nervous system (CNS), interfering brain homeostasis and leading poor patient outcome. Since an integral pivotal part microenvironment, strongly supports occurrence progression here...
The study aims to investigate fungal community structures and dynamic changes in forest soil lignocellulose-degrading process. rRNA gene clone libraries for the samples collected different stages of lignocellulose degradation process were constructed analyzed. A total 26 representative RFLP types obtained from original library, including Mucoromycotina (29.5%), unclassified Zygomycetes (33.5%), Ascomycota (32.4%), Basidiomycota (4.6%). When accumulated with natural lignocellulose, 16...
Lung adenosquamous carcinoma (ASC) is a rare malignant tumor with an adenocarcinoma and squamous cell component associated lower 5-year survival rate than lung adenocarcinoma. Surgical specimen histology revealed the inadequacy of conventional transbronchial needle aspiration samples in diagnosis ASC. Most ASC patients are not suitable to receive surgery, it difficult diagnose This study explore possibility using serum carcinoembryonic antigen (CEA) (SCC) as supplementary diagnostic test for...
Local recurrence is common after radical surgery. However, the factors that contribute to survival local remain unclear. In this retrospective study we analyzed relationship between time and in 74 patients with locally recurrent gastric cancer. All received palliative radiotherapy or without chemotherapy. The were divided into two groups according gastrectomy recurrence: early (ELR, < 12 months primary surgery), late (LLR, ≥12 surgery). median overall (OS) was 15 for ELR 25 LLR patients....
Interleukin (IL)-17 plays a critical role in the pathogenesis of inflammation and autoimmune diseases. The aryl hydrocarbon receptor (AHR) is transcription factor responsible for elimination xenobiotic chemicals. However, it remains unknown whether AHR involved IL-17 signaling. Here, we demonstrate that knockdown significantly enhances, while overexpression or activation inhibits IL-17-induced Hela cells. specifically suppresses p38 activation, inhibition activity markedly reverses effect on...