A5100678450- Atmospheric Ozone and Climate
- Atmospheric chemistry and aerosols
- Atmospheric and Environmental Gas Dynamics
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ionosphere and magnetosphere dynamics
- Streptococcal Infections and Treatments
- Hepatitis C virus research
- Atmospheric aerosols and clouds
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Spectroscopy and Chemometric Analyses
- Perovskite Materials and Applications
- Neurological Disease Mechanisms and Treatments
- SARS-CoV-2 and COVID-19 Research
- Metabolomics and Mass Spectrometry Studies
- COVID-19 Clinical Research Studies
- Effects and risks of endocrine disrupting chemicals
- Surfactants and Colloidal Systems
- Lipid metabolism and biosynthesis
- Aquaculture disease management and microbiota
- Ocean Acidification Effects and Responses
- Neonatal and Maternal Infections
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Foshan University
2023-2025
Tianjin Research Institute of Water Transport Engineering
2025
Chinese Academy of Sciences
2006-2024
Air Force Medical University
2010-2024
Xijing Hospital
2010-2024
La Jolla Bioengineering Institute
2021-2024
University of California, San Diego
2021-2024
Sichuan University
2011-2024
Nanjing Xiaozhuang University
2016-2024
Institute of Atmospheric Physics
2023-2024
Near-infrared light-responsive inorganic nanoparticles have been shown to enhance the efficacy of cancer photothermal ablation therapy. However, current nanoparticle-mediated is more effective in treating local at primary site than metastatic cancer. Here, we report design a near-infrared light-induced transformative nanoparticle platform that combines with immunotherapy. The based on chitosan-coated hollow CuS assemble immunoadjuvants oligodeoxynucleotides containing cytosine-guanine (CpG)...
Currently, detecting SARS-CoV-2 RNAs is a standard approach for COVID-19 diagnosis.However, there an urgent need reliable and rapid serological diagnostic methods to screen SARS-CoV-2infected people including those who do not have overt symptoms.][3][4] Although detection of SARS-CoV-2-specific IgA in serum has been reported few papers, 5,6 analyses levels larger number patients are still lacking.
Gold and copper nanoparticles have been widely investigated for photothermal therapy of cancer. However, degradability toxicity these remain concerns. Here, we compare hollow CuS (HCuSNPs) with gold nanospheres (HAuNS) in similar particle sizes morphology following intravenous administration to mice. The injected pegylated HCuSNPs (PEG-HCuSNPs) are eliminated through both hepatobiliary (67 percentage dose, %ID) renal (23 excretion within one month postinjection. By contrast, 3.98 %ID Au is...
Bacteria-Responsive Multifunctional Nanogel: We developed a bacteria-responsive multifunctional nanogel for targeted antibiotic delivery, in which bacterial enzymes are utilized to trigger release by degrading the polyphosphoester core. The mannosylated preferentially delivers drugs macrophages and leads drug accumulation at infection sites through macrophage transport. This provides targeting lesion site-activatable properties, enhances growth inhibition. Detailed facts of importance...
Silver nanoparticles (Ag NPs) are cytotoxic to cancer cells and possess excellent potential as an antitumor agent. A variety of have been shown induce autophagy, a critical cellular degradation process, the elevated autophagy in most these situations promotes cell death. Whether Ag NPs can how it might affect anticancer activity has not reported. Here we show that induced by activating PtdIns3K signaling pathway. The was characterized enhanced autophagosome formation, normal cargo...
Nitrogen-enriched porous nanocarbon, graphene, and conductive polymers attract increasing attention for application in supercapacitors. However, electrode materials with a large specific surface area (SSA) high nitrogen doping concentration, which is needed excellent supercapacitors, has not been achieved thus far. Herein, we developed class of tetracyanoquinodimethane-derived microporous covalent triazine-based frameworks (TCNQ-CTFs) both content (>8 %) SSA (>3600 m2 g-1 ). These CTFs...
Bivalve molluscs are descendants of an early-Cambrian lineage superbly adapted to benthic filter feeding. Adaptations in form and behavior well recognized, but the underlying molecular mechanisms largely unknown. Here, we investigate genome, various transcriptomes, proteomes scallop Chlamys farreri, a semi-sessile bivalve with well-developed adductor muscle, sophisticated eyes, remarkable neurotoxin resistance. The scallop's large striated muscle is energy-dynamic not fully differentiated...
Abstract A new approach for early detection of multiple cancers is presented by integrating SERS spectroscopy serum molecular fingerprints and machine learning.
Abstract Lipids play crucial roles in many biological processes. Mapping spatial distributions and examining the metabolic dynamics of different lipid subtypes cells tissues are critical to better understanding their aging diseases. Commonly used imaging methods (such as mass spectrometry-based, fluorescence labeling, conventional optical imaging) can disrupt native environment cells/tissues, have limited or spectral resolution, cannot distinguish subtypes. Here we present a hyperspectral...
We developed a high-performance photodetector based on (CH3NH3)3Sb2I9 (MA3Sb2I9) microsingle crystals (MSCs). The MA3Sb2I9 single exhibit low-trap state density of ∼1010 cm–3 and long carrier diffusion length reaching 3.0 μm, suggesting its great potential for optoelectronic applications. However, the centimeter crystal (CSC)-based exhibits low responsivity (10–6 A/W under 1 sun illumination) due to charge-carrier collection efficiency. By constructing MSC with efficient collection, can be...
The interactions of bovine serum albumin (BSA) with cationic gemini surfactants alkanediyl-α,ω-bis(dodecyldimethylammonium bromide) [C12H25(CH3)2N(CH2)SN(CH3)2C12H25]Br2 (designated as C12CSC12Br2, S = 3, 6, and 12) single-chain surfactant dodecyltrimethylammonium bromide (DTAB) have been studied isothermal titration microcalorimetry, turbidity, fluorescence spectroscopy, circular dichroism at pH 7.0. Comparing DTAB, C12CSC12Br2 much stronger binding ability BSA to induce the denaturation...
A lead-free double perovskite, (CH<sub>3</sub>NH<sub>3</sub>)<sub>2</sub>AgBiI<sub>6</sub>, which is rather stable, was investigated using a combination of experiment and density functional theory.
Abstract Nitrogen‐enriched porous nanocarbon, graphene, and conductive polymers attract increasing attention for application in supercapacitors. However, electrode materials with a large specific surface area (SSA) high nitrogen doping concentration, which is needed excellent supercapacitors, has not been achieved thus far. Herein, we developed class of tetracyanoquinodimethane‐derived microporous covalent triazine‐based frameworks (TCNQ‐CTFs) both content (>8 %) SSA (>3600 m 2 g −1 )....
Recent outbreak of flavivirus Zika virus (ZIKV) in America has urged the basic as well translational studies this important human pathogen. The nonstructural protein 5 (NS5) an N-terminal methyltransferase (MTase) domain that plays critical roles viral RNA genome capping. null mutant NS5 MTase is lethal for virus. Therefore, a potential drug target treatment infection. In study, we determined crystal structures ZIKV complex with GTP and cap analogue 7meGpppA. Structural analyses revealed...
Abstract Background The pandemic of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing great loss. Detecting viral RNAs standard approach for SARS-CoV-2 diagnosis with variable success. Currently, studies describing serological diagnostic methods are emerging, while most them just involve detection SARS-CoV-2-specific IgM and IgG by ELISA or “flow immunoassay” limited accuracy. Methods Diagnostic depends on chemiluminescence immunoanalysis (CLIA) detecting IgA,...
Although the power conversion efficiency of perovskite solar cells has improved rapidly, a rational path for further improvement remains unclear. The effect large morphological heterogeneity polycrystalline films on their device performance by photoluminescence (PL) microscopy now been studied. Contrary to common belief deleterious carrier lifetimes and diffusivities, in neat CH3 NH3 PbI3 (Cl) films, local (intra-grain) diffusivities different grains are all surprisingly high (1.5 3.3 cm2...
Lactiplantibacillus plantarum, a major producer of bacteriocins, is generally considered safe microorganism. In this study, Plantaricin FB-2 was extracted from L. plantarum and studied for antimicrobial mechanism against Staphylococcus aureus. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that the size 1–3.3 kDa. non-hemolytic its minimum inhibitory concentration S. aureus ATCC6538 about 256 μg/mL. exerts antibacterial effect by destroying structure bacterial...
n-3 polyunsaturated fatty acids (PUFAs) have been reported to improve depression. However, PUFA purities, caloric content, and ratios in different diets may affect the results. By using Fat-1 mice which convert n-6 PUFAs brain, this study further evaluated anti-depressant mechanisms of a lipopolysaccharide (LPS)-induced model. Adult male wild-type (WT) were fed soybean oil diet for 8 weeks. Depression-like behaviors measured 24 h after saline or LPS central administration. In WT littermates,...
Abstract Crystallization chaperones have been used to facilitate the crystallization of challenging proteins. Even though maltose-binding protein (MBP) is one most commonly chaperones, design optimal expression constructs for MBP fusion proteins remains a challenge. To increase success rate MBP-facilitated crystallization, series vectors designed with either short flexible linker or set rigid helical linkers. Seven death domain superfamily members were tested this vectors, six which had...
To describe the clinical characteristics and outcomes of patients with dual-phenotype hepatocellular carcinoma (DPHCC) investigate use radiomics to establish an image-based signature for preoperative differential diagnosis.This study included 50 a postoperative pathological diagnosis DPHCC (observation group) CK7- CK19-negative HCC (control who attended our hospital between January 2015 December 2018. All underwent Gd-EOB-DTPA-enhanced MRI within 1 month before surgery. Arterial phase (AP),...