A5034144164- Inflammasome and immune disorders
- interferon and immune responses
- Immune Cell Function and Interaction
- Fish Ecology and Management Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Influenza Virus Research Studies
- IL-33, ST2, and ILC Pathways
- Fish Biology and Ecology Studies
- Marine and fisheries research
- Gut microbiota and health
- Marine Bivalve and Aquaculture Studies
- Vagus Nerve Stimulation Research
- T-cell and B-cell Immunology
- Immune cells in cancer
- RNA modifications and cancer
- Gout, Hyperuricemia, Uric Acid
- Immunotherapy and Immune Responses
- Neurological Disease Mechanisms and Treatments
- Sphingolipid Metabolism and Signaling
- Nicotinic Acetylcholine Receptors Study
- Heme Oxygenase-1 and Carbon Monoxide
- Animal Virus Infections Studies
- Wheat and Barley Genetics and Pathology
- Viral gastroenteritis research and epidemiology
University of Science and Technology of China
2015-2025
Tianjin Medical University General Hospital
2014-2025
China Electronics Technology Group Corporation
2025
National Institute of Biological Sciences, Beijing
2017-2025
China Three Gorges Corporation (China)
2012-2024
China Three Gorges University
2017-2024
Taizhou Municipal Hospital
2024
First Hospital of Jilin University
2024
Jilin University
2024
Second Hospital of Hebei Medical University
2023
The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety human diseases. A few compounds have developed to inhibit activation, but directly and specifically targeting are still not available, so it is unclear whether itself can be targeted prevent or treat Here we show that compound CY-09 blocks activation. binds ATP-binding motif NACHT domain inhibits ATPase activity, resulting suppression assembly Importantly, treatment with shows remarkable therapeutic effects on...
Oridonin (Ori) is the major active ingredient of traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but target Ori remains unknown. NLRP3 a central component inflammasome been involved in wide variety chronic inflammation-driven human diseases. Here, we show that specific covalent inhibitor for inflammasome. forms bond with cysteine 279 NACHT domain to block interaction between NEK7, thereby inhibiting assembly activation. Importantly, both preventive...
Research Article12 March 2018Open Access Source DataTransparent process Tranilast directly targets NLRP3 to treat inflammasome-driven diseases Yi Huang Institute of Immunology and the CAS Key Laboratory Innate Immunity Chronic Disease, Center for Excellence in Molecular Cell Sciences, Hefei National Physical Sciences at Microscale, University Science Technology China, Hefei, China Innovation Signaling Network, Search more papers by this author Hua Jiang Yun Chen State Cellular Stress...
The NLRP3 inflammasome can sense different pathogens or danger signals, and has been reported to be involved in the development of many human diseases. Potassium efflux mitochondrial damage are both mediate activation, but underlying, orchestrating signaling events still unclear. Here we show that chloride intracellular channels (CLIC) act downstream potassium efflux-mitochondrial reactive oxygen species (ROS) axis promote activation. agonists induce efflux, which causes ROS production....
ABSTRACT MicroRNAs (miRNAs) are a class of noncoding RNAs lengths ranging from 18 to 23 nucleotides (nt) that play critical roles in wide variety biological processes. There is growing amount evidence miRNAs intricate host-pathogen interaction networks, but the involvement during influenza viral infection unknown. To determine whether cellular an important role H1N1 A infections, 3′ untranslated region (UTR) reporter analysis was used identify putative miRNA targets virus genome, and...
Abstract Background Neuroinflammation and immune responses occurring minutes to hours after stroke are associated with brain injury acute ischemic (AIS). PPARγ coactivator-1α (PGC-1α), as a master coregulator of gene expression in mitochondrial biogenesis, was found be transiently upregulated microglia AIS. However, the role microglial PGC-1α poststroke modulation remains unknown. Methods from human mouse samples following first determined. Subsequently, we employed transgenic mice...
MDA5 plays a critical role in antiviral innate immunity by functioning as cytoplasmic double-stranded RNA sensor that can activate type I interferon signaling pathways, but the mechanism for activation of is poorly understood. Here, we show TRIM65 specifically interacts with and promotes K63-linked ubiquitination at lysine 743, which oligomerization activation. Trim65 deficiency abolishes agonist or encephalomyocarditis virus (EMCV)–induced regulatory factor 3 (IRF3) production has no effect...
NOD2 functions as an intracellular sensor for microbial pathogen and plays important role in epithelial defense. The loss-of-function mutation of is strongly associated with human Crohn’s disease (CD). However, the mechanisms how maintains intestinal homeostasis regulates susceptibility CD are still unclear. Here we found that numbers intraepithelial lymphocytes (IELs) were reduced significantly Nod2−/− mice residual IELs displayed proliferation increased apoptosis. Further study showed...
Inflammation and oxidative stress play an important part in the pathogenesis of focal cerebral ischemia/reperfusion (I/R) injury, resulting neuronal death. The signaling pathways involved underlying mechanisms these events are not fully understood. Chrysin, which is a naturally occurring flavonoid, exhibits various biological activities. In this study, we investigated neuroprotective properties chrysin mouse model middle artery occlusion (MCAO). To end, male C57/BL6 mice were pretreated with...
Rationale: Mitochondrial dysfunction and oxidative stress occur in vascular dementia (VaD), but the specific molecular mechanism regulating these events remains unclear.Peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) is a master regulator for mitochondrial function.This study aims to investigate whether PGC-1α involved pathophysiology of VaD.Methods: We firstly generated f/f Eno2-Cre mice induce neuron-specific overexpression by crossbreeding with Eno2-cre mice.Then,...
NOD2 functions as an intracellular sensor for microbial pathogen and plays important role in epithelial defense. The loss-of-function mutation of is strongly associated with human Crohn's disease (CD). However, the mechanisms how maintains intestinal homeostasis regulates susceptibility CD are still unclear. Here we found that numbers intraepithelial lymphocytes (IELs) were reduced significantly Nod2(-/-) mice residual IELs displayed proliferation increased apoptosis. Further study showed...
Inhaled allergens promote inflammatory response, tissue damage, and airway hyperresponsiveness in the lungs, leading to allergic asthma. NLRP3, as an immune sensor of infections cellular stress, is associated with development exacerbation However, mechanism by which NLRP3 affects asthma requires further investigation. Here, we showed that inhaled house dust mite (HDM) promotes inflammasome activation lungs specifically induces maturation caspase-1 IL-1β alveolar macrophages (AMs). Using...