A5046495441- Plant Molecular Biology Research
- MicroRNA in disease regulation
- Plant Reproductive Biology
- Circular RNAs in diseases
- Plant-Microbe Interactions and Immunity
- RNA Research and Splicing
- Plant Pathogenic Bacteria Studies
- Cancer-related molecular mechanisms research
- Photosynthetic Processes and Mechanisms
- Polysaccharides and Plant Cell Walls
- Legume Nitrogen Fixing Symbiosis
- Cellular Mechanics and Interactions
- RNA modifications and cancer
- Plant Gene Expression Analysis
- RNA Interference and Gene Delivery
- Metabolomics and Mass Spectrometry Studies
- Plant Stress Responses and Tolerance
- Computational Drug Discovery Methods
- Plant nutrient uptake and metabolism
- vaccines and immunoinformatics approaches
- Lipid Membrane Structure and Behavior
- Cancer, Lipids, and Metabolism
- Advanced Drug Delivery Systems
- Lipid metabolism and biosynthesis
- Melanoma and MAPK Pathways
Nanyang Technological University
2017-2025
Second Affiliated Hospital of Jilin University
2024-2025
Heilongjiang University of Chinese Medicine
2019-2023
Central South University
2013-2023
Xiangya Hospital Central South University
2013-2023
Zhejiang Medicine (China)
2020
Jilin University
2015-2019
Macau University of Science and Technology
2019
Zhejiang University
2013-2016
Nanjing Institute of Vegetable Science
2016
Significance Plasmodesmata (PD) create cytoplasmic and membrane continuities between adjacent cells to facilitate cell–cell communication virus movement. Plant have evolved diverse mechanisms regulate PD plasticity against plant pathogens, including the accumulation of defense hormone, salicylic acid (SA). However, mechanism how this occurs is not well understood. Here, we uncover a by which SA triggers Remorin-dependent lipid nanodomain assembly, leading enhancement liquid-ordered phase....
Abstract The intrinsically disordered region (IDR) is a preserved signature of phytobacterial type III effectors (T3Es). T3E IDR thought to mediate unfolding during translocation into the host cell and avoid defense by sequence diversification. Here, we demonstrate mechanism subversion via IDR. We report that Xanthomonas campestris XopR undergoes liquid-liquid phase separation (LLPS) multivalent IDR-mediated interactions hijack Arabidopsis actin cytoskeleton. gradually translocated cells...
Abstract The assembly of macromolecules on the plasma membrane concentrates cell surface biomolecules into nanometer- to micrometer-scale clusters (nano- or microdomains) that help initiate respond signals. In plant–microbe interactions, actin cytoskeleton undergoes rapid remodeling during pathogen-associated molecular pattern-triggered immunity (PTI). nanoclustering formin-actin nucleator proteins at has been identified as underlying nucleation plant innate immune responses. Here, we show...
microRNAs (miRNAs) are endogenous, noncoding, small RNAs that have essential regulatory functions in plant growth, development, and stress response processes. However, limited information is available about their sexual reproduction of flowering plants. Pollen development an important process the life cycle a major factor affects yield quality crop seeds. This study aims to identify miRNAs involved pollen development. Two independent RNA libraries were constructed from flower buds male...
Postmenopausal osteoporosis (PMOP) is a common clinical illness in postmenopausal women, but there no effective drug at present. Metabolomics approach was used to explore the potential biomarkers of PMOP and evaluate efficacy therapeutic targets total lignans stem Acanthophanax senticosus (ASSL) on ovariectomized model rats. UPLC/MS pattern recognition methods were for serum metabolites discovery illustrate pathological mechanism rats, then revealing intervention effect ASSL. The result...
To adapt to the diverse array of biotic and abiotic cues, plants have evolved sophisticated mechanisms sense changes in environmental conditions modulate their growth. Growth-promoting hormones defence signalling fine tune plant development antagonistically. During host-pathogen interactions, this defence-growth trade-off is mediated by counteractive effects hormone salicylic acid (SA) growth auxin. Here we revealed an underlying mechanism SA regulating auxin constraining plasma membrane...
Plants respond to bacterial infection acutely with actin remodeling during plant immune responses. The mechanisms by which virulence factors (VFs) modulate polymerization remain enigmatic. Here, we show that plant-type-I formin serves as the molecular sensor for in response two VFs: Xanthomonas campestris pv. (Xcc) diffusible signal factor (DSF), and pathogen-associated pattern (PAMP) flagellin pattern-triggered immunity (PTI). Both VFs regulate assembly tuning clustering nucleation activity...
MicroRNAs (miRNAs) have been demonstrated to be important in the development and progression of various types cancer. However, exact roles certain anti‑oncogenic miRNAs human malignant gliomas remain elucidated. The present study aimed reveal expression microRNA‑203 (miR-203) normal brain tissues gliomas, investigate role miR-203 cell proliferation migration glioblastoma U251 cells. Real-time reverse transcription polymerase chain reaction (RT-PCR) showed that high WHO grade glioma was...
Lipid metabolism has a significant function in the central nervous system and Alzheimer's disease (AD) is an age-related senile characterized by nerve degeneration. The pathological development of AD closely related to lipid disorders. To reveal influence Kai-Xin-San (KXS) on APP/PSI transgenic mice potential therapeutic targets for treating AD, brain tissue samples were collected analyzed high-throughput lipidomics based UPLC-Q/TOF-MS. raw data processed multivariate analysis discover...
Outer membrane vesicles (OMVs) are released from the outer membranes of Gram-negative bacteria during infection and modulate host immunity host-pathogen interactions. The mechanisms by which OMVs perceived plants affect unclear. Here, we used pathogen Xanthomonas campestris pv. to demonstrate that OMV-plant interactions at Arabidopsis thaliana plasma (PM) various processes, including endocytosis, innate immune responses, suppression pathogenesis phytobacteria. lipid phase is highly ordered...
Cell surface receptors' gradual assembly and oligomerization are vital for controlling receptor activation turnover. However, the spatiotemporal mechanisms of how interactions achieve high efficiency sustain plant immune signaling remain unclear. Here, we synthetically engineered Arabidopsis pattern recognition FLS2 to control its precisely. We investigated dynamic nanoscale assemblies at single-molecule level their corresponding rewired signaling. Engineered exhibits enhanced defense in an...
Malignant glioma is the most common type of cancer in central nervous system, with highly invasive characteristics. The Rho-associated protein kinase (ROCK1) has been found to act as key regulator actin cytoskeleton reorganization, a process closely associated cell invasion. microRNA-145 (miRNA-145) recently shown suppressor several types tumor, including glioma. However, exact regulatory mechanism by which miR-145 inhibits still remains be uncovered. In this study, we report that level was...
Quorum sensing (QS) is a recognized phenomenon that crucial for regulating population-related behaviors in bacteria. However, the direct specific effect of QS molecules on host biology largely understudied. In this work, we show molecule DSF ( cis -11-methyl-dodecenoic acid) produced by Xanthomonas campestris pv. can suppress pathogen-associated molecular pattern–triggered immunity (PTI) Arabidopsis thaliana , mediated flagellin-induced activation flagellin receptor FLS2. The DSF-mediated...
This article has been retracted, and the online PDF watermarked “RETRACTION”. A retraction notice is available at doi: 10.3233/CBM239005.
Insect cuticle is a fiber-reinforced composite material that consists of polysaccharide chitin fibers and protein matrix. The molecular interactions between insect proteins govern the assembly evolution cuticles are still not well understood. Herein, we report Ostrinia furnacalis cuticular hypothetical-1 (OfCPH-1), newly discovered most abundant from Asian corn borer O. furnacalis, can form coacervates in presence chitosan. OfCPH-1–chitosan coacervate microdroplets initially liquid-like but...